Neural basis of memory in primate medial temporal lobe

灵长类内侧颞叶记忆的神经基础

• 批准号: 10527357
• 负责人: Jill K Leutgeb
• 金额: $ 34.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527357
• 关键词: Behavior; Behavioral; Behavioral Paradigm; Brain; Callithrix; Case Study; Cebidae; Cells; Cognitive; Data; Data Set; Disease; Environment; Episodic memory; Experimental Designs; Faculty; Head; Hippocampus; Human; Impairment; Individual; Influentials; Injury; Lesion; Macaca; Medial; Memory; Monkeys; Neurons; Play; Primates; Process; Research; Rodent; Role; Structure; Taxonomy; Technology; Temporal Lobe; Testing; Time; Visual; Work; entorhinal cortex; experimental study; innovation; memory recognition; model organism; neural; neuroimaging; neuromechanism; neurophysiology; nonhuman primate; novel; programs; restraint; way finding

Project Summary The medial temporal lobe (MTL) plays a critical role in the rapid formation of episodic memories in human and nonhuman primates, while research performed in freely-moving rodents has likewise identified these same structure as being pivotal for spatial navigation. Each of these lines of work reflect powerful research traditions that have significantly contributed to our understanding of medial temporal lobe function, but questions remain about how to reconcile their considerable data sets. One compelling hypothesis is that the same neural mechanisms that support the role of MTL in spatial navigation also support the formation of episodic memories. We propose an innovative set of experiments designed to directly test this hypothesis Our approach involves recording neural activity from the same neurons in the medial temporal lobe of marmoset monkeys in two contexts. One involves head-restrained subjects performing a recognition memory task typical of human experiments while in the other freely-moving subjects navigate spatial environments commonly used in studies of rodents. Our innovative approach will allow us to test – for the first time - whether the same neurons in primate medial temporal lobe support behaviors performed in tasks representative of these two research traditions. Aim 1 seeks to characterize recognition memory in marmosets using a task that – like spatial navigation – relies on incidental memory formation. Experiments in Aim 2 examine the role of the hippocampal CA fields and entorhinal cortex in spatial navigation, including the putative existence of place cells and grid cells, respectively. Aim 3 directly tests the principal question of this proposal by recording from the identical neurons while subjects perform the recognition memory task in Aim 1 and navigate spatial environments similar to studies in Aim 2.

项目概要 内侧颞叶（MTL）在情景记忆的快速形成中起着至关重要的作用。 人类和非人类灵长类动物，而在自由活动的啮齿类动物中进行的研究也同样得到了 确定这些相同的结构对于空间导航至关重要。这些工作中的每一项 反映了强大的研究传统，极大地促进了我们对医学的理解 颞叶功能，但如何协调其大量数据集仍然存在问题。一 令人信服的假设是，支持 MTL 在空间中的作用的神经机制相同 导航也支持情景记忆的形成。我们提出了一套创新的 旨在直接检验这一假设的实验我们的方法包括记录神经活动 来自两种情况下狨猴内侧颞叶的相同神经元。一 涉及头部受限的受试者执行人类典型的识别记忆任务 实验而其他自由移动的受试者则导航常用的空间环境 在啮齿动物的研究中。我们的创新方法将使我们能够首次测试是否 灵长类动物内侧颞叶中的相同神经元支持代表任务中执行的行为 这两个研究传统。目标 1 寻求使用狨猴来表征识别记忆 像空间导航一样，这项任务依赖于偶然的记忆形成。目标 2 中的实验 检查海马 CA 区和内嗅皮层在空间导航中的作用，包括 分别假定存在位置单元和网格单元。目标3直接测试主体 当受试者执行以下操作时，通过从相同的神经元进行记录来回答该建议的问题 目标 1 中的识别记忆任务以及与目标 2 中的研究类似的空间环境导航。