Translation and Clinical Implementation of a Test of Language and Short-term Memory (STM) in Aphasia

失语症语言和短期记忆（STM）测试的翻译和临床实施

• 批准号: 10318138
• 负责人: Nadine Martin
• 金额: $ 58.71万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318138
• 关键词: Address; Adverse effects; Affect; Age; Aphasia; Area; Behavior Therapy; Brain Injuries; Characteristics; Chronic; Clinic; Clinical; Cognitive; Communication; Communications Media; Computers; Craniocerebral Trauma; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Focus Groups; Goals; Human; Image; Impairment; Individual; Interview; Knowledge; Laboratories; Language; Language Tests; Lead; Left; Life Style; Linguistics; Maintenance; Manuals; Measures; Memory; Memory impairment; Methods; Modeling; Motivation; Names; Neurologic; Older Population; Performance; Persons; Phase; Preparation; Process; Publications; Quality of life; Questionnaires; Research; Retrieval; Role; Secure; Semantics; Short-Term Memory; Site; Specific qualifier value; Speech; Stimulus; Stroke; Structure; Surveys; Test Result; Testing; Theoretical model; Time; Training; Translating; Translations; United States; Universities; Validation; Washington; Word Processing; aphasia rehabilitation; base; career; clinical implementation; computerized; diagnostic tool; effective intervention; feasibility testing; improved; innovation; interest; language impairment; language processing; meetings; phonology; post implementation; rehabilitation research; relating to nervous system; research clinical testing; response; satisfaction; screening; theories; tool; web site

Aphasia is an acquired impairment of language abilities resulting from damage to the left hemisphere from stroke, head trauma or other neurological conditions. It can affect any aspect of spoken and/or written language processing and can range from mild to severe. As language provides us with a unique form of communication, aphasia can have profound adverse effects on one's quality of life. Although aphasia is more common in older populations, it can occur at any age, and many people with aphasia want to find ways to return to their premorbid lifestyles, including active careers, to the extent that this is possible. Clearly, there is a need for effective clinical tools to diagnose and treat aphasia, but a third factor makes the possibility of meeting this need a reality: More than 30 years of rehabilitation research provides strong evidence that even in chronic stages of aphasia, behavioral interventions lead to improved language function and changes in neural activity of cortical areas known to support language. This project aims to translate a theory-driven and empirically supported diagnostic battery for aphasia (Temple Assessment of Language and Short-term memory in Aphasia, TALSA) to a clinically feasible test battery that can be used for screening or in-depth measures of a language impairment. Importantly, the TALSA is based on a theoretical model of language that incorporates a role of verbal short-term memory (STM) in language processing. Language and verbal STM impairments commonly co-occur in aphasia, and this model attributes that co-occurrence to a common impairment of processes that support access and retrieval of words: weak activation and/or the inability to maintain activation of linguistic representations during word processing. This level of diagnosis is needed to guide impairment-based treatment approaches that directly stimulate access and retrieval processes. The TALSA is unique in that it includes language tests that add memory load and processing time, variables which are sensitive to these processing impairments. The research version of the TALSA is administered on a computer but is lengthy and not practical in a clinical setting. Our aim is to develop a computerized adaptive test version for clinical use. This project will use a Milestone based approach to develop this innovative clinical tool. In the first two years, we will develop the clinical version using focus groups and item response theory to identify the best items and subtests to use in the clinical version of this test (Milestone 1). Goals to meet Milestone 2 will include (1) assessment of participating clinicians' views of current and best practices in aphasia rehabilitation and (2) training participating clinicians on the concepts behind the TALSA, as well as specifics about its administration and interpretation. Milestone 3 will involve implementation of the clinical version in the clinical settings and assessment of clinicians' responses to its usefulness and validation of the clinical version, in relation to the original version. Plans for dissemination of the final clinical version of the TALSA will include development of a secured website enabling access to the preliminary version (in Years 3-5) and arrangements for publication of the final version in Year 5.

失语症是一种后天性的语言能力损伤， 中风、头部创伤或其他神经系统疾病。它可以影响口语和/或书面语言的任何方面 处理范围从轻度到严重。语言为我们提供了一种独特的交流方式， 失语症会对一个人的生活质量产生深远的负面影响。虽然失语症在老年人中更常见， 在人群中，它可能发生在任何年龄，许多失语症患者希望找到恢复病前状态的方法 生活方式，包括积极的职业生涯，只要有可能。显然，需要有效的临床治疗。 诊断和治疗失语症的工具，但第三个因素使满足这一需求成为现实的可能性：更多 30多年的康复研究提供了强有力的证据，即使在失语症的慢性阶段， 行为干预导致语言功能的改善和皮质区神经活动的变化 已知支持语言。该项目旨在将理论驱动和经验支持的诊断 失语症成套测验（Temple Assessment of Language and Short-term Memory in Aphasia，TALSA） 可用于筛查或深入测量语言障碍的可行成套测试。重要的是， TALSA是基于语言的理论模型，该模型包含了口头短期记忆的作用 (STM)在语言处理中。语言和言语短时记忆障碍通常共同发生在失语症中，这 模型属性，共现的过程，支持访问和检索的共同损害 单词：弱激活和/或在单词过程中无法维持语言表征的激活 处理.需要这种诊断水平来指导基于损伤的治疗方法， 促进存取和检索过程。TALSA的独特之处在于它包括语言测试， 存储器负载和处理时间、对这些处理损害敏感的变量。 研究版本的TALSA是在计算机上管理，但在临床上是冗长和不实用的。 设置.我们的目标是开发一个计算机化的自适应测试版本，供临床使用。该项目将使用一个 基于里程碑的方法来开发这种创新的临床工具。在前两年，我们将开发临床 版本使用焦点小组和项目反应理论，以确定最好的项目和子测试中使用的临床 本测试的版本（里程碑1）。实现里程碑2的目标将包括（1）评估参与临床医生的 对失语症康复的当前和最佳实践的看法;（2）培训参与的临床医生， TALSA背后的概念，以及有关其管理和解释的细节。里程碑3将 涉及在临床环境中实施临床版本，并评估临床医生对 与原始版本相比，临床版本的有效性和验证。传播计划 TALSA的最终临床版本将包括开发一个安全的网站， 初步版本（3-5年级）和安排在5年级出版最终版本。