Predoctoral Training Program in Virology

项目概要/摘要 本申请是对耶鲁大学病毒学博士前培训项目继续支持的请求 大学其目标是提供多学科的研究培训，以博士生在分子 病毒生物学、病毒-宿主相互作用和人类病毒性疾病的发病机制。这预计将 为病毒学相关的生产性职业提供必要的知识和研究基础 学术界、工业界和政府的学科。该计划提供几乎所有方面的培训， 现代病毒学，包括病毒遗传学，病毒的分子，细胞和结构生物学，适应性和 对病毒的先天免疫反应，细胞和生物体水平上的病毒-宿主相互作用，以及 病毒性疾病治疗的转化研究。该计划由Priti Kumar博士共同指导 和瓦尔特·莫斯，以及一个5人顾问委员会。该方案得到了加强， 增加新的教员和课程，以涵盖病毒学的新兴关键领域。作为一个群体，22 培训员在研究成就和培训方面有着出色的记录，许多是本国的， 各领域的国际领导人。这些培训师在耶鲁大学14个不同的系有主要任命 目前有51名博士前病毒学实习生在他们的实验室工作。 学生通过生物和生物医学科学的综合课程进入该课程 （BBS）。BBS联合了耶鲁医学院近375名基础生物和生物医学科学教师 学校，科学山的主要大学校园，和新开发的西校区。入场 奖学金发放给成绩优异的学生，特别注重研究经验。的 教师作出广泛的努力，以吸引和留住来自不同背景的学员，特别是根据- 代表少数群体。该计划得到了对研究生培训的强有力的机构承诺的支持。 博士前培训导致博士学位。学位涉及正式的课程工作和实验室轮换， 第一年这提供了一个坚实而广泛的概念基础和实验训练微生物学， 免疫学、细胞生物学、遗传学以及生物学的其他领域。学生选择一个研究顾问在 在第一年结束时，并在第二年开始时的资格考试中捍卫研究提案。 论文委员会在整个论文研究过程中监测学生的进步。强化培训 研究的方法、逻辑和负责任的行为得到了广泛的机会的补充 用于教学和科学互动。获得博士学位的平均时间学历5.4年。这 申请要求继续资助每年四名博士前学员，每名学员 这项补助金最多支持两年。

PROJECT SUMMARY/ABSTRACT This application is a request for continuation of support for a pre-doctoral Training Program in Virology at Yale University. The goal is to provide multidisciplinary research training to predoctoral students in the molecular biology of viruses, virus-host interactions, and pathogenesis in human viral diseases. This is expected to provide the intellectual and research foundations necessary for productive careers in virology-related disciplines in academia, industry, and government. The program offers training in virtually all aspects of modern virology including viral genetics, the molecular, cellular and structural biology of viruses, adaptive and innate immune response to viruses, virus-host interactions at the cellular and organismal levels as well as translational research towards the treatment of viral diseases. The program is co-directed by Drs. Priti Kumar and Walther Mothes, and a 5 member Advisory Committee. The program has been strengthened by the addition of new Faculty trainers and courses to cover emerging critical areas of virology. As a group, the 22 trainers have an outstanding record of research accomplishment and training and many are national or international leaders in their fields. These trainers have primary appointments in 14 different Yale departments and currently have 51 predoctoral virology trainees working in their labs. Students enter the program through the Combined Program in Biological and Biomedical Sciences (BBS). The BBS unites nearly 375 faculty in basic biological and biomedical sciences at the Yale Medical School, Science Hill on the main University Campus, and the newly developed West Campus. Admission is granted to students with outstanding academic record with particular attention to research experience. The Faculty makes extensive efforts to attract and retain trainees from diverse backgrounds, particularly under- represented minority groups. The program is supported by strong institutional commitment to graduate training. Predoctoral training leading to the Ph.D. degree involves formal course work and laboratory rotations in the first year. This provides a solid and broad conceptual foundation and experimental training in microbiology, immunology, cell biology, genetics, as well as other areas of biology. Students select a research advisor at the end of the first year and defend a research proposal in a qualifying exam at the beginning of the second year. A Thesis Committee monitors student progress throughout the thesis research process. Intensive training in the methods, logic, and responsible conduct of research are supplemented with a wide array of opportunities for teaching and scientific interactions. The median time to obtain the Ph.D. degree is 5.4 years. This application requests funding to continue support for four predoctoral trainees in each year, with each trainees supported by this grant for a maximum of two years.