Pre-doctoral Training in Systems Toxicology

系统毒理学博士前培训

基本信息

  • 批准号:
    10633220
  • 负责人:
  • 金额:
    $ 16.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

SUMMARY/ABSTRACT Inhalation exposures to diverse airborne toxicants are an ever-present, rising and ubiquitous public health threat in our environments whether it be outdoor air pollution, industrial processes, or indoor domestic or occupational toxicants. Inhalation exposures are widely associated with adverse health outcomes in major physiological systems such as: pulmonary (asbestosis, black lung, silicosis); cardiovascular (ischemia, infarction); neural (stroke, behavior), immune (inflammation); and endocrine/reproductive (disruption, developmental origins of health and disease). The whole of West Virginia is part of Appalachia, wherein significant health disparities such as cardiovascular/cerebrovascular disease, obesity, diabetes, metabolic syndrome, depression and addiction are disproportionately high. Further, poor socioeconomic status, and geography (thermal inversions) trap communities in the immediate proximity of mountain-top mining (surface mining) and hydraulic fracturing (“fracking”) operations that produce tremendous amounts of industrial air pollution. An immediate demand exists to train the next generation of scientists able to accurately assess the complex interplay among these toxicological risks, and ultimately improve public health in West Virginia and the nation. The Predoctoral Training in Systems Toxicology Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on inhalation toxicology research. Several innovative aspects of this training program are semester-long didactic courses in “Toxicology” and the “Inhalation & Aerosol Sciences”, a unique “Environmental Immersion” in community outreach/engagement via air sampling downwind of mountaintop/surface mines and fracking platforms, the “Paracelsus Society” colloquium and journal club, an Associate Scholars Program and leadership training. This rigorous training program will select the best doctoral students from the participating Biomedical Sciences Ph.D. and Clinical & Translational Sciences Ph.D. training programs at the West Virginia University (WVU) Health Sciences Center (WVU HSC) and Engineering and will prepare them with the skills, knowledge and acumen needed for a successful career in the diverse field of toxicology. It is projected that up to 40 trainees will be enrolled in this program during the funding period. The specific training for each mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and a “Career Options” Program will help prepare them for their chosen career in diverse fields. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can directly address the need for innovative toxicology research for the citizens of West Virginia, Appalachia, and the nation.
摘要/文摘

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Proteome derangement in malignant epithelial cells and its stroma following exposure to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
暴露于4-(甲基硝基氨基氨基)后,恶性上皮细胞及其基质中的蛋白质组破坏 - 1-(3-吡啶基)-1-丁酮。
  • DOI:
    10.1007/s00204-022-03426-8
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    6.1
  • 作者:
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Timothy R Nurkiewicz其他文献

Timothy R Nurkiewicz的其他文献

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{{ truncateString('Timothy R Nurkiewicz', 18)}}的其他基金

Pre-doctoral Training in Systems Toxicology
系统毒理学博士前培训
  • 批准号:
    10410578
  • 财政年份:
    2022
  • 资助金额:
    $ 16.13万
  • 项目类别:
Microvascular Health and Nanoparticle Exposure
微血管健康和纳米颗粒暴露
  • 批准号:
    7938733
  • 财政年份:
    2009
  • 资助金额:
    $ 16.13万
  • 项目类别:
Microvascular Health and Nanoparticle Exposure
微血管健康和纳米颗粒暴露
  • 批准号:
    7815673
  • 财政年份:
    2009
  • 资助金额:
    $ 16.13万
  • 项目类别:
Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming
母体纳米材料暴露:胎儿微血管端点和编程
  • 批准号:
    9769021
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Remote Microvascular Dysfunction After Particulate Matter Exposure
颗粒物暴露后的远程微血管功能障碍
  • 批准号:
    7486839
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Remote Microvascular Dysfunction After Particulate Matter Exposure
颗粒物暴露后的远程微血管功能障碍
  • 批准号:
    7878866
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Remote Microvascular Dysfunction After Particulate Matter Exposure
颗粒物暴露后远端微血管功能障碍
  • 批准号:
    7637839
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming
母体纳米材料暴露:胎儿微血管端点和编程
  • 批准号:
    10246378
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming
母体纳米材料暴露:胎儿微血管端点和编程
  • 批准号:
    9445027
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:
Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming
母体纳米材料暴露:胎儿微血管端点和编程
  • 批准号:
    8575971
  • 财政年份:
    2007
  • 资助金额:
    $ 16.13万
  • 项目类别:

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系统药理学和毒理学培训 (T-SPaT)
  • 批准号:
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  • 财政年份:
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  • 资助金额:
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  • 项目类别:
Pre-doctoral Training in Systems Toxicology
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    $ 16.13万
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  • 批准号:
    10629288
  • 财政年份:
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  • 项目类别:
Training in Molecular and Systems Toxicology
分子和系统毒理学培训
  • 批准号:
    10159931
  • 财政年份:
    2019
  • 资助金额:
    $ 16.13万
  • 项目类别:
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分子和系统毒理学培训
  • 批准号:
    10415885
  • 财政年份:
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  • 资助金额:
    $ 16.13万
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  • 批准号:
    9310432
  • 财政年份:
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毒理学指导和技能发展培训计划
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  • 财政年份:
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系统药理学和毒理学培训计划
  • 批准号:
    9063078
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    2013
  • 资助金额:
    $ 16.13万
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Systems Pharmacology and Toxicology Training Program
系统药理学和毒理学培训计划
  • 批准号:
    10166861
  • 财政年份:
    2013
  • 资助金额:
    $ 16.13万
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Systems Pharmacology and Toxicology Training Program
系统药理学和毒理学培训计划
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  • 项目类别:
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