Pre-doctoral Training in Systems Toxicology

摘要/摘要 公众吸入各种空气中有毒物质的情况一直存在，且不断增加且无处不在 我们环境中的健康威胁，无论是室外空气污染、工业过程还是室内 家庭或职业毒物。吸入暴露与不良健康广泛相关 主要生理系统的结果，例如： 肺部（石棉肺、黑肺、矽肺）； 心血管（缺血、梗塞）；神经（中风、行为）、免疫（炎症）；和 内分泌/生殖（健康和疾病的破坏、发育起源）。整个西域 弗吉尼亚州是阿巴拉契亚地区的一部分，那里存在显着的健康差异，例如 心脑血管疾病、肥胖、糖尿病、代谢综合征、抑郁症等 成瘾率高得不成比例。此外，较差的社会经济地位和地理（热 反转）将社区困在山顶采矿（露天采矿）附近 水力压裂（“水力压裂”）作业会产生大量工业空气污染。 迫切需要培训下一代科学家，使其能够准确评估 这些毒理学风险之间复杂的相互作用，最终改善西弗吉尼亚州的公共卫生 和国家。系统毒理学博士前培训计划将正式化并 标准化我们在生物医学领域已经很强大的培训计划，并重点关注吸入 毒理学研究。该培训计划的几个创新方面是为期一个学期的教学 “毒理学”和“吸入与气溶胶科学”课程，独特的“环境沉浸” 通过山顶/露天矿井顺风空气采样进行社区外展/参与， 水力压裂平台、“Paracelsus Society”研讨会和期刊俱乐部、副学者 计划和领导力培训。这种严格的培养计划将选拔最优秀的博士生 来自参与生物医学科学博士。和临床与转化科学博士培训 西弗吉尼亚大学 (WVU) 健康科学中心 (WVU HSC) 和工程项目 并将为他们提供在该领域取得成功职业所需的技能、知识和敏锐度 毒理学的不同领域。预计期间将招收多达40名学员 资助期限。每个受训者的具体培训将根据他们每年更新的情况量身定制 个性化发展计划（IDP）和“职业选择”计划将帮助他们为自己的职业生涯做好准备 在不同领域选择职业。项目培训预计持续2至3年。这个博士前 培训计划将培养新一代年轻学者，他们可以直接满足 为西弗吉尼亚州、阿巴拉契亚地区和整个国家的公民进行创新毒理学研究。

SUMMARY/ABSTRACT Inhalation exposures to diverse airborne toxicants are an ever-present, rising and ubiquitous public health threat in our environments whether it be outdoor air pollution, industrial processes, or indoor domestic or occupational toxicants. Inhalation exposures are widely associated with adverse health outcomes in major physiological systems such as: pulmonary (asbestosis, black lung, silicosis); cardiovascular (ischemia, infarction); neural (stroke, behavior), immune (inflammation); and endocrine/reproductive (disruption, developmental origins of health and disease). The whole of West Virginia is part of Appalachia, wherein significant health disparities such as cardiovascular/cerebrovascular disease, obesity, diabetes, metabolic syndrome, depression and addiction are disproportionately high. Further, poor socioeconomic status, and geography (thermal inversions) trap communities in the immediate proximity of mountain-top mining (surface mining) and hydraulic fracturing (“fracking”) operations that produce tremendous amounts of industrial air pollution. An immediate demand exists to train the next generation of scientists able to accurately assess the complex interplay among these toxicological risks, and ultimately improve public health in West Virginia and the nation. The Predoctoral Training in Systems Toxicology Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on inhalation toxicology research. Several innovative aspects of this training program are semester-long didactic courses in “Toxicology” and the “Inhalation & Aerosol Sciences”, a unique “Environmental Immersion” in community outreach/engagement via air sampling downwind of mountaintop/surface mines and fracking platforms, the “Paracelsus Society” colloquium and journal club, an Associate Scholars Program and leadership training. This rigorous training program will select the best doctoral students from the participating Biomedical Sciences Ph.D. and Clinical & Translational Sciences Ph.D. training programs at the West Virginia University (WVU) Health Sciences Center (WVU HSC) and Engineering and will prepare them with the skills, knowledge and acumen needed for a successful career in the diverse field of toxicology. It is projected that up to 40 trainees will be enrolled in this program during the funding period. The specific training for each mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and a “Career Options” Program will help prepare them for their chosen career in diverse fields. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can directly address the need for innovative toxicology research for the citizens of West Virginia, Appalachia, and the nation.