Pre-doctoral Training in Systems Toxicology

总结/摘要 吸入暴露于各种空气中的有毒物质是一个永远存在的，不断上升和无处不在的公众 我们环境中的健康威胁，无论是室外空气污染、工业过程还是室内 家庭或职业毒物。吸入暴露与不良健康广泛相关 主要生理系统的结果，如：肺（石棉肺，黑肺，矽肺）; 心血管（缺血、梗死）;神经（中风、行为）;免疫（炎症）;以及 内分泌/生殖（干扰、健康和疾病的发育起源）。整个西方 弗吉尼亚州是阿巴拉契亚的一部分，在那里， 心血管/脑血管疾病、肥胖症、糖尿病、代谢综合征、抑郁症和 成瘾率高得不成比例。此外，贫穷的社会经济地位，和地理（热 倒置）将群落困在山顶采矿（露天采矿）附近， 水力压裂（“压裂”）操作产生大量的工业空气污染。 迫切需要培养下一代科学家，能够准确评估 这些毒理学风险之间的复杂相互作用，并最终改善西弗吉尼亚州的公共健康 和民族系统毒理学计划的博士前培训将正式化， 标准化我们已经强大的生物医学科学培训计划，并专注于吸入 毒理学研究这个培训计划的几个创新方面是一个学期的教学 课程在“毒理学”和“吸入和气溶胶科学”，一个独特的“环境沉浸” 通过在山顶/露天矿的下风处进行空气采样， 水力压裂平台，“帕拉塞尔苏斯社会”座谈会和期刊俱乐部，一个副学者 计划和领导力培训。这个严格的培训计划将选拔最优秀的博士生 生物医学科学博士临床与转化科学博士培训 西弗吉尼亚大学（WVU）健康科学中心（WVU HSC）和工程 并将准备他们的技能，知识和敏锐性所需要的一个成功的职业生涯， 毒理学的不同领域。预计在2010年期间，将有多达40名受训人员参加这一方案。 融资期。每个学员的具体培训将根据他们每年更新的 个性化发展计划（IDP）和“职业选择”计划将帮助他们为他们的职业生涯做好准备。 在不同领域选择职业。项目培训预计将持续2至3年。这个博士预科 培训计划将培养新一代的年轻学者，他们可以直接解决 为西弗吉尼亚州，阿巴拉契亚和全国的公民进行创新的毒理学研究。

SUMMARY/ABSTRACT Inhalation exposures to diverse airborne toxicants are an ever-present, rising and ubiquitous public health threat in our environments whether it be outdoor air pollution, industrial processes, or indoor domestic or occupational toxicants. Inhalation exposures are widely associated with adverse health outcomes in major physiological systems such as: pulmonary (asbestosis, black lung, silicosis); cardiovascular (ischemia, infarction); neural (stroke, behavior), immune (inflammation); and endocrine/reproductive (disruption, developmental origins of health and disease). The whole of West Virginia is part of Appalachia, wherein significant health disparities such as cardiovascular/cerebrovascular disease, obesity, diabetes, metabolic syndrome, depression and addiction are disproportionately high. Further, poor socioeconomic status, and geography (thermal inversions) trap communities in the immediate proximity of mountain-top mining (surface mining) and hydraulic fracturing (“fracking”) operations that produce tremendous amounts of industrial air pollution. An immediate demand exists to train the next generation of scientists able to accurately assess the complex interplay among these toxicological risks, and ultimately improve public health in West Virginia and the nation. The Predoctoral Training in Systems Toxicology Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on inhalation toxicology research. Several innovative aspects of this training program are semester-long didactic courses in “Toxicology” and the “Inhalation & Aerosol Sciences”, a unique “Environmental Immersion” in community outreach/engagement via air sampling downwind of mountaintop/surface mines and fracking platforms, the “Paracelsus Society” colloquium and journal club, an Associate Scholars Program and leadership training. This rigorous training program will select the best doctoral students from the participating Biomedical Sciences Ph.D. and Clinical & Translational Sciences Ph.D. training programs at the West Virginia University (WVU) Health Sciences Center (WVU HSC) and Engineering and will prepare them with the skills, knowledge and acumen needed for a successful career in the diverse field of toxicology. It is projected that up to 40 trainees will be enrolled in this program during the funding period. The specific training for each mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and a “Career Options” Program will help prepare them for their chosen career in diverse fields. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can directly address the need for innovative toxicology research for the citizens of West Virginia, Appalachia, and the nation.