Pre-doctoral Training in Systems Toxicology

摘要/摘要 吸入暴露于各种空气中的毒物是一个无处不在、不断上升的公众 我们环境中的健康威胁，无论是室外空气污染、工业过程还是室内 家用或职业性毒物。吸入暴露广泛地与不良健康有关。 主要生理系统的转归，如肺(石棉肺、黑肺、矽肺)； 心血管(缺血、梗塞)；神经(中风、行为)、免疫(炎症)；以及 内分泌/生殖(干扰、健康和疾病的发育根源)。整个西部 弗吉尼亚州是阿巴拉契亚的一部分，那里存在着显著的健康差距，如 心脑血管疾病、肥胖、糖尿病、代谢综合征、抑郁症和 上瘾率高得不成比例。此外，较差的社会经济地位和地理位置(热 倒置)山顶采矿(露天采矿)附近的圈闭社区 水力压裂(“水力压裂”)作业会产生大量的工业空气污染。 迫切需要培养下一代能够准确评估 这些毒物风险之间复杂的相互作用，并最终改善西弗吉尼亚州的公共健康 还有这个国家。系统毒理学的博士前培训将正式和 标准化我们在生物医学科学方面已经很强大的培训计划，并专注于吸入性 毒物学研究。这一培训计划的几个创新方面是为期一学期的教学 “毒理学”和“吸入与气溶胶科学”课程--一种独特的“环境沉浸式” 通过山顶/露天地雷的顺风向空气采样和 水力压裂平台，“Paracelsus学会”学术讨论会和杂志俱乐部，副学者 计划和领导力培训。这一严格的培训计划将挑选出最好的博士生 参加生物医学博士和临床与翻译科学博士培训 西弗吉尼亚大学(WVU)健康科学中心(WVU HSC)和工程 并将使他们具备在职业生涯中取得成功所需的技能、知识和敏锐性 不同的毒物学领域。预计年内将有多达40名学员报名参加这项计划。 资助期。每个学员的具体培训将根据他们每年更新的情况量身定做 个性化发展计划(IDP)和职业选择计划将帮助他们为他们的 在不同的领域选择职业。计划培训预计将持续2至3年。这位博士后 培训计划将培养新一代年轻学者，他们可以直接解决 为西弗吉尼亚州、阿巴拉契亚和全国的公民进行创新的毒理学研究。

SUMMARY/ABSTRACT Inhalation exposures to diverse airborne toxicants are an ever-present, rising and ubiquitous public health threat in our environments whether it be outdoor air pollution, industrial processes, or indoor domestic or occupational toxicants. Inhalation exposures are widely associated with adverse health outcomes in major physiological systems such as: pulmonary (asbestosis, black lung, silicosis); cardiovascular (ischemia, infarction); neural (stroke, behavior), immune (inflammation); and endocrine/reproductive (disruption, developmental origins of health and disease). The whole of West Virginia is part of Appalachia, wherein significant health disparities such as cardiovascular/cerebrovascular disease, obesity, diabetes, metabolic syndrome, depression and addiction are disproportionately high. Further, poor socioeconomic status, and geography (thermal inversions) trap communities in the immediate proximity of mountain-top mining (surface mining) and hydraulic fracturing (“fracking”) operations that produce tremendous amounts of industrial air pollution. An immediate demand exists to train the next generation of scientists able to accurately assess the complex interplay among these toxicological risks, and ultimately improve public health in West Virginia and the nation. The Predoctoral Training in Systems Toxicology Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on inhalation toxicology research. Several innovative aspects of this training program are semester-long didactic courses in “Toxicology” and the “Inhalation & Aerosol Sciences”, a unique “Environmental Immersion” in community outreach/engagement via air sampling downwind of mountaintop/surface mines and fracking platforms, the “Paracelsus Society” colloquium and journal club, an Associate Scholars Program and leadership training. This rigorous training program will select the best doctoral students from the participating Biomedical Sciences Ph.D. and Clinical & Translational Sciences Ph.D. training programs at the West Virginia University (WVU) Health Sciences Center (WVU HSC) and Engineering and will prepare them with the skills, knowledge and acumen needed for a successful career in the diverse field of toxicology. It is projected that up to 40 trainees will be enrolled in this program during the funding period. The specific training for each mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and a “Career Options” Program will help prepare them for their chosen career in diverse fields. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can directly address the need for innovative toxicology research for the citizens of West Virginia, Appalachia, and the nation.