Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view

摘要 该项目的最终目标是解决乳腺癌筛查中未得到满足的临床需求。 高乳房密度。这一群体(BI-RADS密度C级和D级)占妇女的近一半。这个 高乳房密度将乳房X光检查的敏感度降低到62%，而且它还与两倍的 更高的乳腺癌风险(美国妇产科医师学会，女性癌症管理 乳房致密由乳房X光摄影诊断，2016年)。目前已有30个州通过了乳房密度通知 根据法律，目前还没有对乳房致密患者进行大规模筛查的有前景的方法。例如， 乳房超声(US)依赖于操作员，灵敏度有限，假阳性率高； 动态对比度增强(DCE)乳腺磁共振成像(MRI)的成本高，需要 注射Gd形成对比，且可获得性有限。为了解决这个问题，这个项目将制定三个- 具有光声(PA)和US成像能力的三维(3D)乳房筛查系统。这个 该提案利用了该团队在双扫描PA技术方面的最新进展，该技术利用了两个线性 换能器阵列和两个线性光纤束从两个颅骨成像轻微受压的乳房 和尾侧(CC)。该样机采用了新颖的共面光学照明和声探测设计， 系统通过7厘米厚的压缩乳房成功成像。这一深度从来没有达到过 任何其他PA乳房成像系统。CC-VIEW检测还以熟悉的形式呈现图像 放射科医生。此外，该系统是便携的，并以站立的姿势为患者成像，这两个特征都是 将极大地方便临床工作流程。本次R01项目将进一步推进双扫描系统，实现 更好的乳房覆盖率、更高的空间分辨率、更好的US能力以及多参数量化 乳房组织。为了确保项目的成功实施，该团队拥有多学科的专业知识。 在光声学、超声波、计算信息学、生物统计学以及乳腺肿瘤学和放射学。 该项目还获得了水牛城最繁忙的两个乳房成像中心-罗斯威尔公园-的支持 癌症研究所和WindSong放射学集团。该项目的具体目标如下：目标1.发展 紧凑的双扫描光声和超声乳房成像系统。目标2.发展光声和 超声图像采集与处理算法。目的3.研究光声和超声波 乳腺恶性肿瘤的特点。

ABSTRACT The ultimate goal of this project is to address the unmet clinical need in breast cancer screening for women with high breast density. This population (BI-RADS density grades C and D) accounts for nearly half of women. The high breast density reduces mammography sensitivity to as low as 62%, and it is also associated with a two-fold higher risk of breast cancer (American College of Obstetricians and Gynecologists, Management of Women With Dense Breasts Diagnosed by Mammography, 2016). While 30 states have now passed breast density notification laws, there is no promising modality for large-scale screening of patients with dense breasts. For instance, the breast ultrasound (US) is operator-dependent, and has limited sensitivity and a high false positive rate; while dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) is limited by its high cost, required injection of gadolinium contrast, and limited availability. To address this issue, this project will develop a three- dimensional (3D) breast screening system with both photoacoustic (PA) and US imaging capabilities. The proposal is capitalized on the team’s recent advances in the double-scan PA technology, which utilized two linear transducer arrays and two linear optical fiber bundles to image a slightly compressed breast from both the cranial and caudal (CC) sides. With a novel co-planar optical illumination and acoustic detection design, the prototype system successfully imaged through a 7-cm-thick compressed breast. This depth has never been achieved by any other PA breast imaging systems. The CC-view detection also presents images in a form that is familiar to radiologists. In addition, the system is portable and images the patient in a standing pose, both of these features will significantly facilitate clinical workflow. This R01 project will further advance the dual-scan system to achieve better breast coverage, higher spatial resolution, better US capability, and multi-parametric quantification of breast tissue. To ensure successful implementation of the project, the team possesses multidisciplinary expertise in photoacoustics, ultrasound, computational informatics, biostatistics, as well as breast oncology and radiology. The project has also secured support from the Buffalo’s two busiest breast imaging centers ― Roswell Park Cancer Institute and Windsong Radiology Group. The specific aims of the project are as follows: Aim 1. Develop a compact double-scan photoacoustic and ultrasonic breast imaging system. Aim 2. Develop photoacoustic and ultrasound image acquisition and processing algorithms. Aim 3. Investigate photoacoustic and ultrasonic features of breast malignancy.