Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view

摘要 该项目的最终目标是解决乳腺癌筛查中未满足的临床需求， 乳腺密度高。这一人口（BI-RADS密度等级C和D）几乎占妇女的一半。的 高乳腺密度会使乳房X线摄影的灵敏度降低到62%，而且它还与乳腺癌的双重危险有关。 乳腺癌的风险更高（美国妇产科医师学会， 乳腺X线摄影诊断的致密乳房，2016）。虽然30个州现在已经通过了乳腺密度通知 根据法律，目前还没有一种有希望的方式来大规模筛查致密乳腺患者。你比如说 乳腺超声（US）依赖于操作者，灵敏度有限，假阳性率高; 动态对比度增强（DCE）乳腺磁共振成像（MRI）受到其高成本、所需 注射钆造影剂，并且可用性有限。为了解决这一问题，该项目将开发一个三- 三维（3D）乳房筛查系统，具有光声（PA）和US成像能力。的 该提案利用了该团队在双扫描PA技术方面的最新进展，该技术利用了两个线性 传感器阵列和两个线性光纤束，从颅侧对轻微压迫的乳房进行成像 和尾侧（CC）。该样机采用了新颖的共面光学照明和声检测设计， 系统通过7 cm厚的压缩乳房成功成像。这一深度从未达到过 任何其他PA乳腺成像系统。CC视图检测还以熟悉的形式呈现图像。 放射科医生此外，该系统是便携式的，并以站立姿势对患者进行成像，这两个特征 将大大促进临床工作流程。此R 01项目将进一步推进双扫描系统， 更好的乳房覆盖，更高的空间分辨率，更好的US能力，以及多参数量化 乳房组织为确保项目的成功实施，该小组拥有多学科的专门知识 在光声学、超声学、计算信息学、生物统计学以及乳腺肿瘤学和放射学方面。 该项目还得到了布法罗两个最繁忙的乳房成像中心-罗斯韦尔公园的支持 癌症研究所和Windsong放射组。该项目的具体目标如下：目标1。发展 紧凑的双扫描光声和超声乳房成像系统。目标二。开发光声和 超声图像采集和处理算法。目标3。研究光声和超声 乳腺恶性肿瘤的特征。

ABSTRACT The ultimate goal of this project is to address the unmet clinical need in breast cancer screening for women with high breast density. This population (BI-RADS density grades C and D) accounts for nearly half of women. The high breast density reduces mammography sensitivity to as low as 62%, and it is also associated with a two-fold higher risk of breast cancer (American College of Obstetricians and Gynecologists, Management of Women With Dense Breasts Diagnosed by Mammography, 2016). While 30 states have now passed breast density notification laws, there is no promising modality for large-scale screening of patients with dense breasts. For instance, the breast ultrasound (US) is operator-dependent, and has limited sensitivity and a high false positive rate; while dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) is limited by its high cost, required injection of gadolinium contrast, and limited availability. To address this issue, this project will develop a three- dimensional (3D) breast screening system with both photoacoustic (PA) and US imaging capabilities. The proposal is capitalized on the team’s recent advances in the double-scan PA technology, which utilized two linear transducer arrays and two linear optical fiber bundles to image a slightly compressed breast from both the cranial and caudal (CC) sides. With a novel co-planar optical illumination and acoustic detection design, the prototype system successfully imaged through a 7-cm-thick compressed breast. This depth has never been achieved by any other PA breast imaging systems. The CC-view detection also presents images in a form that is familiar to radiologists. In addition, the system is portable and images the patient in a standing pose, both of these features will significantly facilitate clinical workflow. This R01 project will further advance the dual-scan system to achieve better breast coverage, higher spatial resolution, better US capability, and multi-parametric quantification of breast tissue. To ensure successful implementation of the project, the team possesses multidisciplinary expertise in photoacoustics, ultrasound, computational informatics, biostatistics, as well as breast oncology and radiology. The project has also secured support from the Buffalo’s two busiest breast imaging centers ― Roswell Park Cancer Institute and Windsong Radiology Group. The specific aims of the project are as follows: Aim 1. Develop a compact double-scan photoacoustic and ultrasonic breast imaging system. Aim 2. Develop photoacoustic and ultrasound image acquisition and processing algorithms. Aim 3. Investigate photoacoustic and ultrasonic features of breast malignancy.