Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds
开发用于慢性伤口组织灌注非侵入性、无标记成像的光声断层扫描技术
基本信息
- 批准号:10404566
- 负责人:
- 金额:$ 42.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcousticsAddressAffectAmbulatory Care FacilitiesAmericanAmputationAngiographyAnkleBiometryBloodBlood CirculationBlood VesselsBuffaloesChronicClinicClinicalClinical TrialsClinical and Translational Science AwardsContrast MediaControl GroupsCountyDataDecision MakingDetectionDevelopmentDiffusionDiseaseDoppler UltrasoundEnsureEvaluationGenerationsGeometryGoalsGuidelinesHemoglobinHospitalsHybridsImageInterventionLabelLasersLeg UlcerLightLightingLocationMedical centerMicrocirculationModalityMonitorNeuropathyOperative Surgical ProceduresOpticsOutcomeOxygenPatientsPenetrationPerformancePerfusionPhotoplethysmographyPhysiologic pulsePositioning AttributeQuality of lifeResolutionSchemeSecureSignal TransductionSkinStasis UlcerSurgeonSurgical woundSystemSystems DevelopmentTechniquesTestingThree-Dimensional ImagingTimeTissue imagingTissuesToesTransducersTreatment CostUlcerUnited States National Institutes of HealthUniversitiesVenousVisitVisualVisualizationWorkX-Ray Computed Tomographyabsorptionbaseblood perfusionchronic ulcerchronic woundclinical riskclinical translationcomputer sciencedecubitus ulcerdesigndiabeticdiabetic patienteffectiveness analysisfeasibility testingfollow-upfoothemodynamicshigh resolution imagingimage processingimaging capabilitiesimaging modalityimaging platformimaging systemimprovedindexinginnovationmortalitymultidisciplinarynephrotoxicityoptoacoustic tomographyphotoacoustic imagingportabilitypressurepreventprogramsreconstructionrevascularization surgerysystems researchtooltreatment grouptreatment planningtwo-dimensionalultrasoundwoundwound carewound healingwound treatment
项目摘要
Project summary
Chronic leg ulcers are affecting approximately 6.5 million Americans and the disease includes venous stasis
ulcers, arterial ulcers, pressure ulcers, and diabetic (neuropathic) ulcers. They are associated with significant
mortality (28% over two years), reduced quality of life (nonambulatory), and high treatment costs (>$25 billion/yr
in the U.S.). Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of blood
perfusion to the wound is critical to treatment planning and monitoring. However, existing clinical tests fail to
meet this need in practice. Without timely information on circulation, a patient may need to wait months after the
revascularization surgery before any additional intervention can be planned. An accurate, noninvasive tool for
circulation assessment would greatly improve post-surgical decision making and clinical outcomes of wound
patients. This project aims to develop a three-dimensional (3D) wound assessment system using photoacoustic
tomography (PAT), a hybrid modality that detects optical absorption in tissue through the photoacoustic effect.
The conversion of optical absorption into acoustic waves breaks through the optical diffusion limit, allowing for
high-resolution imaging in three dimensions. Since hemoglobin serves as the major endogenous contrast at
near-infrared wavelengths, PAT provides label-free, three-dimensional imaging of hemoglobin distribution, which
is closely related to circulation. While PAT has shown promising results in vascular imaging, various hurdles
have prevented its application in wound evaluation. Capitalizing on the recent innovations in photoacoustic
system development and image processing, the team will address these hurdles and develop a PAT-based
wound imaging system with unique advantages in terms of spatial resolution, penetration depth, and portability.
To ensure successful implementation of the project, the PI has gathered a multidisciplinary team with expertise
in photoacoustic imaging, wound healing, vascular surgery, biostatistics, and computer science. The project has
also secured support from the region’s busiest vascular clinic located at Buffalo Generation Hospital and Erie
County Medical Center and their outpatient clinics. More importantly, the team has already worked together and
acquired preliminary data through support from the University at Buffalo’s NIH Clinical and Translational Science
Awards (CTSA) Program. Through the four-year project, the team will achieve the following aims: Aim 1: Develop
a versatile, high-resolution 3D photoacoustic imaging system that can be easily rotated and positioned to image
any regions on the foot; Aim 2: Validate the system at vascular clinics and identify photoacoustic features of
tissue perfusion; and Aim 3: Test the feasibility of using PAT to monitor tissue perfusion and guide post-surgical
assessment and treatment planning.
Project summary
Chronic leg ulcers are affecting approximately 6.5 million Americans and the disease includes venous stasis
ulcers, arterial ulcers, pressure ulcers, and diabetic (neuropathic) ulcers. They are associated with significant
mortality (28% over two years), reduced quality of life (nonambulatory), and high treatment costs (>$25 billion/yr
in the U.S.). Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of blood
perfusion to the wound is critical to treatment planning and monitoring. However, existing clinical tests fail to
meet this need in practice. Without timely information on circulation, a patient may need to wait months after the
revascularization surgery before any additional intervention can be planned. An accurate, noninvasive tool for
circulation assessment would greatly improve post-surgical decision making and clinical outcomes of wound
patients. This project aims to develop a three-dimensional (3D) wound assessment system using photoacoustic
tomography (PAT), a hybrid modality that detects optical absorption in tissue through the photoacoustic effect.
The conversion of optical absorption into acoustic waves breaks through the optical diffusion limit, allowing for
high-resolution imaging in three dimensions. Since hemoglobin serves as the major endogenous contrast at
near-infrared wavelengths, PAT provides label-free, three-dimensional imaging of hemoglobin distribution, which
is closely related to circulation. While PAT has shown promising results in vascular imaging, various hurdles
have prevented its application in wound evaluation. Capitalizing on the recent innovations in photoacoustic
system development and image processing, the team will address these hurdles and develop a PAT-based
wound imaging system with unique advantages in terms of spatial resolution, penetration depth, and portability.
To ensure successful implementation of the project, the PI has gathered a multidisciplinary team with expertise
in photoacoustic imaging, wound healing, vascular surgery, biostatistics, and computer science. The project has
also secured support from the region’s busiest vascular clinic located at Buffalo Generation Hospital and Erie
County Medical Center and their outpatient clinics. More importantly, the team has already worked together and
acquired preliminary data through support from the University at Buffalo’s NIH Clinical and Translational Science
Awards (CTSA) Program. Through the four-year project, the team will achieve the following aims: Aim 1: Develop
a versatile, high-resolution 3D photoacoustic imaging system that can be easily rotated and positioned to image
any regions on the foot; Aim 2: Validate the system at vascular clinics and identify photoacoustic features of
tissue perfusion; and Aim 3: Test the feasibility of using PAT to monitor tissue perfusion and guide post-surgical
assessment and treatment planning.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jun Xia其他文献
Jun Xia的其他文献
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{{ truncateString('Jun Xia', 18)}}的其他基金
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水通道蛋白 3 在砷诱导的 DNA 损伤和突变中的作用
- 批准号:
10634794 - 财政年份:2022
- 资助金额:
$ 42.4万 - 项目类别:
The Role of Aquaporin 3 in Arsenic-Induced DNA Damage and Mutagenesis
水通道蛋白 3 在砷诱导的 DNA 损伤和突变中的作用
- 批准号:
10679054 - 财政年份:2022
- 资助金额:
$ 42.4万 - 项目类别:
Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds
开发用于慢性伤口组织灌注非侵入性、无标记成像的光声断层扫描技术
- 批准号:
10209788 - 财政年份:2021
- 资助金额:
$ 42.4万 - 项目类别:
The Role of Aquaporin 3 in Arsenic-Induced DNA Damage and Mutagenesis
水通道蛋白 3 在砷诱导的 DNA 损伤和突变中的作用
- 批准号:
10283270 - 财政年份:2021
- 资助金额:
$ 42.4万 - 项目类别:
Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds
开发用于慢性伤口组织灌注非侵入性、无标记成像的光声断层扫描技术
- 批准号:
10569031 - 财政年份:2021
- 资助金额:
$ 42.4万 - 项目类别:
Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view
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$ 42.4万 - 项目类别:
Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view
乳房头尾视图的多参数光声和超声成像
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10320755 - 财政年份:2020
- 资助金额:
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