Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds

开发用于慢性伤口组织灌注非侵入性、无标记成像的光声断层扫描技术

• 批准号: 10404566
• 负责人: Jun Xia
• 金额: $ 42.4万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404566
• 关键词: 3-Dimensional; Acoustics; Address; Affect; Ambulatory Care Facilities; American; Amputation; Angiography; Ankle; Biometry; Blood; Blood Circulation; Blood Vessels; Buffaloes; Chronic; Clinic; Clinical; Clinical Trials; Clinical and Translational Science Awards; Contrast Media; Control Groups; County; Data; Decision Making; Detection; Development; Diffusion; Disease; Doppler Ultrasound; Ensure; Evaluation; Generations; Geometry; Goals; Guidelines; Hemoglobin; Hospitals; Hybrids; Image; Intervention; Label; Lasers; Leg Ulcer; Light; Lighting; Location; Medical center; Microcirculation; Modality; Monitor; Neuropathy; Operative Surgical Procedures; Optics; Outcome; Oxygen; Patients; Penetration; Performance; Perfusion; Photoplethysmography; Physiologic pulse; Positioning Attribute; Quality of life; Resolution; Scheme; Secure; Signal Transduction; Skin; Stasis Ulcer; Surgeon; Surgical wound; System; Systems Development; Techniques; Testing; Three-Dimensional Imaging; Time; Tissue imaging; Tissues; Toes; Transducers; Treatment Cost; Ulcer; United States National Institutes of Health; Universities; Venous; Visit; Visual; Visualization; Work; X-Ray Computed Tomography; absorption; base; blood perfusion; chronic ulcer; chronic wound; clinical risk; clinical translation; computer science; decubitus ulcer; design; diabetic; diabetic patient; effectiveness analysis; feasibility testing; follow-up; foot; hemodynamics; high resolution imaging; image processing; imaging capabilities; imaging modality; imaging platform; imaging system; improved; indexing; innovation; mortality; multidisciplinary; nephrotoxicity; optoacoustic tomography; photoacoustic imaging; portability; pressure; prevent; programs; reconstruction; revascularization surgery; systems research; tool; treatment group; treatment planning; two-dimensional; ultrasound; wound; wound care; wound healing; wound treatment

Project summary Chronic leg ulcers are affecting approximately 6.5 million Americans and the disease includes venous stasis ulcers, arterial ulcers, pressure ulcers, and diabetic (neuropathic) ulcers. They are associated with significant mortality (28% over two years), reduced quality of life (nonambulatory), and high treatment costs (>$25 billion/yr in the U.S.). Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of blood perfusion to the wound is critical to treatment planning and monitoring. However, existing clinical tests fail to meet this need in practice. Without timely information on circulation, a patient may need to wait months after the revascularization surgery before any additional intervention can be planned. An accurate, noninvasive tool for circulation assessment would greatly improve post-surgical decision making and clinical outcomes of wound patients. This project aims to develop a three-dimensional (3D) wound assessment system using photoacoustic tomography (PAT), a hybrid modality that detects optical absorption in tissue through the photoacoustic effect. The conversion of optical absorption into acoustic waves breaks through the optical diffusion limit, allowing for high-resolution imaging in three dimensions. Since hemoglobin serves as the major endogenous contrast at near-infrared wavelengths, PAT provides label-free, three-dimensional imaging of hemoglobin distribution, which is closely related to circulation. While PAT has shown promising results in vascular imaging, various hurdles have prevented its application in wound evaluation. Capitalizing on the recent innovations in photoacoustic system development and image processing, the team will address these hurdles and develop a PAT-based wound imaging system with unique advantages in terms of spatial resolution, penetration depth, and portability. To ensure successful implementation of the project, the PI has gathered a multidisciplinary team with expertise in photoacoustic imaging, wound healing, vascular surgery, biostatistics, and computer science. The project has also secured support from the region’s busiest vascular clinic located at Buffalo Generation Hospital and Erie County Medical Center and their outpatient clinics. More importantly, the team has already worked together and acquired preliminary data through support from the University at Buffalo’s NIH Clinical and Translational Science Awards (CTSA) Program. Through the four-year project, the team will achieve the following aims: Aim 1: Develop a versatile, high-resolution 3D photoacoustic imaging system that can be easily rotated and positioned to image any regions on the foot; Aim 2: Validate the system at vascular clinics and identify photoacoustic features of tissue perfusion; and Aim 3: Test the feasibility of using PAT to monitor tissue perfusion and guide post-surgical assessment and treatment planning.

Project summary Chronic leg ulcers are affecting approximately 6.5 million Americans and the disease includes venous stasis ulcers, arterial ulcers, pressure ulcers, and diabetic (neuropathic) ulcers. They are associated with significant mortality (28% over two years), reduced quality of life (nonambulatory), and high treatment costs (>$25 billion/yr in the U.S.). Since many chronic ulcers have underlying vascular insufficiency, accurate assessment of blood perfusion to the wound is critical to treatment planning and monitoring. However, existing clinical tests fail to meet this need in practice. Without timely information on circulation, a patient may need to wait months after the revascularization surgery before any additional intervention can be planned. An accurate, noninvasive tool for circulation assessment would greatly improve post-surgical decision making and clinical outcomes of wound patients. This project aims to develop a three-dimensional (3D) wound assessment system using photoacoustic tomography (PAT), a hybrid modality that detects optical absorption in tissue through the photoacoustic effect. The conversion of optical absorption into acoustic waves breaks through the optical diffusion limit, allowing for high-resolution imaging in three dimensions. Since hemoglobin serves as the major endogenous contrast at near-infrared wavelengths, PAT provides label-free, three-dimensional imaging of hemoglobin distribution, which is closely related to circulation. While PAT has shown promising results in vascular imaging, various hurdles have prevented its application in wound evaluation. Capitalizing on the recent innovations in photoacoustic system development and image processing, the team will address these hurdles and develop a PAT-based wound imaging system with unique advantages in terms of spatial resolution, penetration depth, and portability. To ensure successful implementation of the project, the PI has gathered a multidisciplinary team with expertise in photoacoustic imaging, wound healing, vascular surgery, biostatistics, and computer science. The project has also secured support from the region’s busiest vascular clinic located at Buffalo Generation Hospital and Erie County Medical Center and their outpatient clinics. More importantly, the team has already worked together and acquired preliminary data through support from the University at Buffalo’s NIH Clinical and Translational Science Awards (CTSA) Program. Through the four-year project, the team will achieve the following aims: Aim 1: Develop a versatile, high-resolution 3D photoacoustic imaging system that can be easily rotated and positioned to image any regions on the foot; Aim 2: Validate the system at vascular clinics and identify photoacoustic features of tissue perfusion; and Aim 3: Test the feasibility of using PAT to monitor tissue perfusion and guide post-surgical assessment and treatment planning.