Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view

乳房头尾视图的多参数光声和超声成像

• 批准号: 10579172
• 负责人: Jun Xia
• 金额: $ 35.73万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10579172
• 关键词: 3-Dimensional; Acoustics; Address; Algorithms; American College of Obstetricians and Gynecologists; Biometry; Blood; Breast; Breast Cancer Detection; Breast Cancer Patient; Breast Cancer Risk Factor; Breast Magnetic Resonance Imaging; Breast Oncology; Cancer Patient; Cephalic; Chest wall structure; Clinic; Clinical; Collaborations; Data; Detection; Diagnosis; Elements; Ensure; Fiber Optics; Foundations; Gadolinium; Goals; Image; Informatics; Injections; Lateral; Laws; Light; Lighting; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Ultrasonography; Mammography; Methods; Modality; Notification; Optics; Patient Recruitments; Patient imaging; Patients; Penetration; Population; Property; Radiology Specialty; Reading; Resolution; Roswell Park Cancer Institute; Scanning; Secure; Side; Signal Transduction; System; Techniques; Technology; Testing; Thick; Tissues; Transducers; Ultrasonics; Ultrasonography; Visualization; Woman; Work; breast density; breast imaging; breast malignancies; cancer imaging; clinical investigation; contrast enhanced; cost; density; design; elastography; feature extraction; high risk; imaging capabilities; imaging facilities; imaging modality; imaging system; malignant breast neoplasm; member; multidisciplinary; multimodality; novel; optical fiber; patient screening; photoacoustic imaging; portability; programs; prototype; radiologist; research and development; sound; ultrasound

ABSTRACT The ultimate goal of this project is to address the unmet clinical need in breast cancer screening for women with high breast density. This population (BI-RADS density grades C and D) accounts for nearly half of women. The high breast density reduces mammography sensitivity to as low as 62%, and it is also associated with a two-fold higher risk of breast cancer (American College of Obstetricians and Gynecologists, Management of Women With Dense Breasts Diagnosed by Mammography, 2016). While 30 states have now passed breast density notification laws, there is no promising modality for large-scale screening of patients with dense breasts. For instance, the breast ultrasound (US) is operator-dependent, and has limited sensitivity and a high false positive rate; while dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) is limited by its high cost, required injection of gadolinium contrast, and limited availability. To address this issue, this project will develop a three- dimensional (3D) breast screening system with both photoacoustic (PA) and US imaging capabilities. The proposal is capitalized on the team’s recent advances in the double-scan PA technology, which utilized two linear transducer arrays and two linear optical fiber bundles to image a slightly compressed breast from both the cranial and caudal (CC) sides. With a novel co-planar optical illumination and acoustic detection design, the prototype system successfully imaged through a 7-cm-thick compressed breast. This depth has never been achieved by any other PA breast imaging systems. The CC-view detection also presents images in a form that is familiar to radiologists. In addition, the system is portable and images the patient in a standing pose, both of these features will significantly facilitate clinical workflow. This R01 project will further advance the dual-scan system to achieve better breast coverage, higher spatial resolution, better US capability, and multi-parametric quantification of breast tissue. To ensure successful implementation of the project, the team possesses multidisciplinary expertise in photoacoustics, ultrasound, computational informatics, biostatistics, as well as breast oncology and radiology. The project has also secured support from the Buffalo’s two busiest breast imaging centers ― Roswell Park Cancer Institute and Windsong Radiology Group. The specific aims of the project are as follows: Aim 1. Develop a compact double-scan photoacoustic and ultrasonic breast imaging system. Aim 2. Develop photoacoustic and ultrasound image acquisition and processing algorithms. Aim 3. Investigate photoacoustic and ultrasonic features of breast malignancy.

摘要

项目成果

Trans-illumination intestine projection imaging of intestinal motility in mice.

• DOI: 10.1038/s41467-021-21930-w
• 发表时间: 2021-03-16
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Wang D;Zhang H;Vu T;Zhan Y;Malhotra A;Wang P;Chitgupi U;Rai A;Zhang S;Wang L;Huizinga JD;Lovell JF;Xia J
• 通讯作者: Xia J