Pennington MoTrPAC Adults

彭宁顿 MoTrPAC 成人

• 批准号: 10320475
• 负责人: Tuomo Rankinen
• 金额: $ 237.5万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2023-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320475
• 关键词: 21 year old; Abdomen; Acute; Adipose tissue; Adult; Aerobic; Aerobic Exercise; African American population; Back; Biological; Biology; Biomedical Research; Biopsy; Blood; Body Composition; Body mass index; Caucasians; Cell Culture Techniques; Clinical Trials; Collection; Control Groups; Data; Development; Disease; Enrollment; Equipment; Exercise; General Population; Genetic; Goals; Health; Health Promotion; Heart Rate; Heritability; Heterogeneity; Human; Individual; Individual Differences; Intervention; Intervention Trial; Life Style; Lifting; Maps; Measures; Molecular; Morbidity - disease rate; Multicenter Studies; Muscle; Muscle Fibers; Participant; Pathway interactions; Performance; Physical activity; Population Heterogeneity; Positioning Attribute; Randomized; Randomized Clinical Trials; Recommendation; Regimen; Research; Research Personnel; Resistance; Rest; Risk Factors; Running; Sampling; Scheme; Skeletal Muscle; Specimen; Sports; Supervision; Testing; Training; Training Programs; Transducers; Translational Research; Vision; Walking; active control; aged; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; exercise intervention; exercise training; experience; healthy lifestyle; improved; intervention participants; mortality; muscle strength; novel; precision medicine; programs; recruit; resistance exercise; response; sample collection; sedentary; skills; strength training; success; treadmill; treatment arm; vigorous intensity; volunteer

PROJECT SUMMARY ABSTRACT A considerable body of evidence shows that exercise training induces multiple beneficial changes in cardiometabolic risk factors and that physically active individuals have lower mortality and morbidity rates than their sedentary counterparts. However, there are marked inter-individual differences in the responsiveness to regular physical activity with some individuals showing great benefits while others do not. While the response heterogeneity is clearly genetically determined, little is known about the molecular pathways and mechanisms that contribute to the adaptation to acute exercise and exercise training. The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to “understand the molecular changes that occur in response to physical activity”. We therefore propose to conduct a randomized clinical trial in which we will collect biological samples (blood, skeletal muscle and adipose tissue) before and after a 12-week aerobic or resistance training program in healthy, sedentary individuals. In addition, we will collect samples before, during and after a single bout of exercise at baseline and after training. We will also collect biosamples in highly trained athletes involved in endurance or strength sports. The overarching goal of the program is to contribute to the development of a molecular map of transducers that underlie the effects of physical activity. To achieve this goal, investigators at the Pennington Biomedical Research Center propose to: 1) Enroll and randomize 518 healthy, but sedentary volunteers (50% Caucasians, 47.5% African Americans, 2.5% others; aged 21-75 y; BMI 20-40 kg/m2) in a 3/3/1 scheme to a 12-week intervention trial comprised of two exercise groups, aerobic (AER) and resistance (RES) training, and a control group (CON). The goal is to have 178 completers in each training group and 60 in the CON group (20% attrition). 2) Recruit and enroll 50 athletes (ATH) competing in endurance (n=25) and strength (n=25) sports to serve as an active control group. The ATH group will undergo baseline testing and an acute bout of exercise consistent with their normal training regimen with similar pre- and post-acute exercise samples collection. The AER program will start at 3 days per week of treadmill walking/running progressing to 4 days per week by week 2 with an initial moderate intensity (heart rate associated with 50% VO2peak), then increasing to a more vigorous intensity (HR 75% VO2peak) by week 6. The RES program will be performed 3 days per week and consist of 9 exercises on Universal Gym Equipment, including four upper body lifts, three lower body lifts, abdominal crunch, and back extensions. The RES program will progress from 2 sets of 10-20 repetitions to 3 sets of 8-10 repetitions after week 2. All AER and RES exercise sessions will be conducted under strict supervision by trained staff. Because of the expertise in training studies and translational research as well as the availability of state-of-the-art facilities, Pennington investigators are well positioned to recruit/retain a diverse population, conduct the proposed trial and collect/store the necessary biosamples.

项目摘要 摘要 大量的证据表明，运动训练诱导多种有益的变化， 心脏代谢危险因素，身体活跃的人有较低的死亡率和发病率， 他们久坐不动的同伴然而，有显着的个体间差异的反应， 定期的身体活动，有些人表现出很大的好处，而其他人则没有。尽管答复 异质性显然是由遗传决定的，但对分子途径和机制知之甚少。 有助于对急性运动和运动训练的适应。分子传感器的目标 物理活动联盟（MoTrPAC）的目标是“了解响应于 体力活动”。因此，我们建议进行一项随机临床试验， 12周有氧或阻力训练前后的血液、骨骼肌和脂肪组织样本 在健康的、久坐的人身上。此外，我们将在单次检查之前、期间和之后收集样本。 在基线和训练后进行一次锻炼。我们还将收集训练有素的运动员的生物样本 参与耐力或力量运动。该计划的首要目标是促进 开发身体活动影响的传感器分子图谱。 为了实现这一目标，彭宁顿生物医学研究中心的研究人员建议： 1)招募并随机选择518名健康但久坐的志愿者（50%为白人，47.5%为非洲人 美国人，2.5%其他人;年龄21-75岁; BMI 20-40 kg/m2），3/3/1方案，12周干预试验 包括两个运动组，有氧（AER）和阻力（RES）训练，以及对照组（CON）。 目标是每个训练组有178名完成者，CON组有60名完成者（20%自然减员）。 2)招募并招募50名参加耐力（n=25）和力量（n=25）运动的运动员（ATH）， 作为一个积极的对照组。ATH组将接受基线测试和急性运动 与他们的正常训练方案一致，具有类似的急性运动前和急性运动后样品收集。 AER计划将从每周3天的跑步机步行/跑步开始，到每周4天， 第2周，初始强度为中等强度（心率与50% VO 2峰值相关），然后增加至更高强度。 到第6周，剧烈强度（HR 75% VO 2峰值）。RES计划将每周进行3天， 包括9个通用健身设备上的练习，包括四个上身升降机，三个下身升降机， 腹部紧缩和背部伸展RES程序将从2组10-20次重复进展到3组 第2周后重复8-10次。所有AER和RES演习将在严格的 由训练有素的工作人员监督。由于在培训研究和翻译研究方面的专业知识， 最先进的设施的可用性，彭宁顿调查人员有能力招聘/留住一个 不同人群，开展拟定试验并收集/储存必要的生物样本。