HERITAGE FAMILY STUDY, PHASE 4
HERITAGE FAMILY STUDY, PHASE 4
批准号:
7340187
负责人:
Tuomo Rankinen
金额:
$66.82万
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-01 至 2011-02-28
关键词:
AdultAllelesAntithymoglobulinAreaBiological AssayBiologyBiomedical ResearchCandidate Disease GeneCodeCollaborationsComplexComputer SimulationDNA SequenceDataData AnalysesDatabasesDeath RateElectrophoretic Mobility Shift AssayElementsExerciseFamilyFamily StudyFunctional RNAGene MutationGenesGenetic HeterogeneityGenetic VariationGenomicsGoalsHaplotypesHeart RateHeterogeneityHumanIn VitroIndividual DifferencesInternationalInterventionIntronsKinesinLife StyleLinkLod ScoreLow PrevalenceLuciferasesMapsMeasurementMessenger RNAMicrosatellite RepeatsMolecularMonitorMorbidity - disease rateMutationNoiseNuclear FamilyNumbersOther Working GroupsPhasePhenotypePhysical activityProcessPromoter RegionsPropertyProstaglandins AProteinsPublic HealthQuantitative Trait LociResearchResearch DesignResearch PersonnelResourcesRisk FactorsScanningScreening procedureSignal TransductionSingle Nucleotide PolymorphismSubgroupTerminator CodonTestingTrainingTraining ProgramsTreesUniversitiesUntranslated RegionsVariantWashingtonWeekauthoritybasecardiovascular risk factorcohortconnectindesignexperiencefitnessgene discoverygenetic linkage analysisgenome-wide linkagehemodynamicsnoveloptimismpositional cloningprogramspromoterprotein structureresponsesuccesstooltrait
中文摘要
规律的身体活动与良好的心血管危险因素相关,患病率较低
英文摘要
Regular physical activity is associated with a favorable cardiovascular risk factor profile, a lower prevalence
of morbidities and reduced premature death rates. However, individual differences are observed in the
magnitude of benefits derived from a physically active lifestyle. This phenomenon was investigated in the
previous phases of the HERITAGE Family Study in which 742 Blacks and Whites from 214 nuclear families,
all adults, completed a standardized and fully monitored 20-week exercise training program. There were
large inter-individual differences in responsiveness but this heterogeneity was not randomly distributed, as
there was significant familial resemblance in the magnitude of the risk factor responses to the exercise
program. These differences in response have been associatedwith a number of candidate genes. Moreover,
extensive analyses of the data have made it possible to identify several quantitative trait loci (QTLs) for the
responses in important risk factors. In this renewal period (Phase 4; 2005 to 2010), our main goal is to
conclude the positional cloning efforts of four QTLs for the response of cardiorespiratory fitness and
hemodynamic phenotypes to regular exercise, to resolve them in terms of candidate genes and
allelic variants, and to functionally confirm them. Investigators from the Pennington Biomedical
Research Center and from Washington University are submitting a single revised application to continue the
close collaboration established over the last 12 years in pursuing the proposed positional cloning goals. The
hypothesis to be tested in Phase 4 of the HERITAGE Family Study is that human cardiorespiratory fitness
and hemodvnamic changes in response to regular exercise are regulated by a minimum of four QTLs. Two
of these QTLs have yielded strong candidate genes: titin (TTN; QTL1), and kinesin 5B (KIF5B; QTL2). We
propose to finalize the positional cloning efforts of two other QTLs for cardiorespiratory fitness as well as
exercise heart rate phenotypes, i.e., QTLS and QTL4 (Specific Aim1). Furthermore, we will continue the
ongoing in vitro studies to characterize the functional properties of the alleles of the SNPs that have been
associated with the response to regular exercise (Specific Aim 2). This research will generate unique data
concerning the biology of adaptation and the molecular basis of human heterogeneity in the responsiveness
to regular exercise. Studies designed to understand why some people are fundamentally more likely to
benefit from a physically active lifestyle than others are very important as such a lifestyle is recommended by
all national and international public health authorities.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Pennington MoTrPAC Adults
-
批准号:10391629
-
项目类别:
-
资助金额:$3.2万
-
财政年份:2016
-
负责人:Tuomo Rankinen
-
依托单位:
Pennington MoTrPAC Adults
-
批准号:10265138
-
项目类别:
-
资助金额:$3.59万
-
财政年份:2016
-
负责人:Tuomo Rankinen
-
依托单位:
Pennington MoTrPAC Adults
-
批准号:10320475
-
项目类别:
-
资助金额:$237.5万
-
财政年份:2016
-
负责人:Tuomo Rankinen
-
依托单位:
Pennington MoTrPAC Adults
-
批准号:9246830
-
项目类别:
-
资助金额:$24.8万
-
财政年份:2016
-
负责人:Tuomo Rankinen
-
依托单位:
HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
-
批准号:6997862
-
项目类别:
-
资助金额:$30.2万
-
财政年份:2004
-
负责人:Tuomo Rankinen
-
依托单位:
HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
-
批准号:6727017
-
项目类别:
-
资助金额:$33.02万
-
财政年份:2004
-
负责人:Tuomo Rankinen
-
依托单位:
HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
-
批准号:6845271
-
项目类别:
-
资助金额:$31.71万
-
财政年份:2004
-
负责人:Tuomo Rankinen
-
依托单位:
HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
-
批准号:7159332
-
项目类别:
-
资助金额:$30.12万
-
财政年份:2004
-
负责人:Tuomo Rankinen
-
依托单位:
HERITAGE FAMILY STUDY, PHASE 4
-
批准号:7792493
-
项目类别:
-
资助金额:$69.09万
-
财政年份:1992
-
负责人:Tuomo Rankinen
-
依托单位:
HERITAGE FAMILY STUDY, PHASE 4
-
批准号:7574400
-
项目类别:
-
资助金额:$68.63万
-
财政年份:1992
-
负责人:Tuomo Rankinen
-
依托单位:
海外基金