Pennington MoTrPAC Adults

彭宁顿 MoTrPAC 成人

• 批准号: 10391629
• 负责人: Tuomo Rankinen
• 金额: $ 3.2万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391629
• 关键词: 21 year old; Abdomen; Acute; Adipose tissue; Adult; Aerobic; Aerobic Exercise; African American; Back; Biological; Biology; Biomedical Research; Biopsy; Blood; Body Composition; Body mass index; Caucasians; Cell Culture Techniques; Clinical Trials; Collection; Control Groups; Data; Development; Disease; Enrollment; Equipment; Exercise; General Population; Genetic; Goals; Health; Health Promotion; Heart Rate; Heritability; Heterogeneity; Human; Individual; Individual Differences; Intervention; Intervention Trial; Life Style; Lifting; Maps; Measures; Molecular; Morbidity - disease rate; Multicenter Studies; Muscle; Muscle Fibers; Participant; Pathway interactions; Performance; Physical activity; Population Heterogeneity; Positioning Attribute; Randomized; Randomized Clinical Trials; Recommendation; Regimen; Research; Research Personnel; Resistance; Rest; Risk Factors; Running; Sampling; Scheme; Skeletal Muscle; Specimen; Sports; Supervision; Testing; Training; Training Programs; Transducers; Translational Research; Vision; Walking; active control; aged; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; exercise intervention; exercise training; experience; healthy lifestyle; improved; intervention participants; mortality; muscle strength; novel; precision medicine; programs; recruit; resistance exercise; response; sample collection; sedentary; skills; strength training; success; treadmill; treatment arm; vigorous intensity; volunteer

PROJECT SUMMARY ABSTRACT A considerable body of evidence shows that exercise training induces multiple beneficial changes in cardiometabolic risk factors and that physically active individuals have lower mortality and morbidity rates than their sedentary counterparts. However, there are marked inter-individual differences in the responsiveness to regular physical activity with some individuals showing great benefits while others do not. While the response heterogeneity is clearly genetically determined, little is known about the molecular pathways and mechanisms that contribute to the adaptation to acute exercise and exercise training. The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to “understand the molecular changes that occur in response to physical activity”. We therefore propose to conduct a randomized clinical trial in which we will collect biological samples (blood, skeletal muscle and adipose tissue) before and after a 12-week aerobic or resistance training program in healthy, sedentary individuals. In addition, we will collect samples before, during and after a single bout of exercise at baseline and after training. We will also collect biosamples in highly trained athletes involved in endurance or strength sports. The overarching goal of the program is to contribute to the development of a molecular map of transducers that underlie the effects of physical activity. To achieve this goal, investigators at the Pennington Biomedical Research Center propose to: 1) Enroll and randomize 518 healthy, but sedentary volunteers (50% Caucasians, 47.5% African Americans, 2.5% others; aged 21-75 y; BMI 20-40 kg/m2) in a 3/3/1 scheme to a 12-week intervention trial comprised of two exercise groups, aerobic (AER) and resistance (RES) training, and a control group (CON). The goal is to have 178 completers in each training group and 60 in the CON group (20% attrition). 2) Recruit and enroll 50 athletes (ATH) competing in endurance (n=25) and strength (n=25) sports to serve as an active control group. The ATH group will undergo baseline testing and an acute bout of exercise consistent with their normal training regimen with similar pre- and post-acute exercise samples collection. The AER program will start at 3 days per week of treadmill walking/running progressing to 4 days per week by week 2 with an initial moderate intensity (heart rate associated with 50% VO2peak), then increasing to a more vigorous intensity (HR 75% VO2peak) by week 6. The RES program will be performed 3 days per week and consist of 9 exercises on Universal Gym Equipment, including four upper body lifts, three lower body lifts, abdominal crunch, and back extensions. The RES program will progress from 2 sets of 10-20 repetitions to 3 sets of 8-10 repetitions after week 2. All AER and RES exercise sessions will be conducted under strict supervision by trained staff. Because of the expertise in training studies and translational research as well as the availability of state-of-the-art facilities, Pennington investigators are well positioned to recruit/retain a diverse population, conduct the proposed trial and collect/store the necessary biosamples.

项目总结 摘要 大量证据表明，运动训练能引起多种有益的变化 心脏代谢危险因素，体育活动个人的死亡率和发病率低于 他们久坐不动的对手。然而，个体之间的反应存在显著差异。 有规律的体力活动，一些人表现出很大的益处，而另一些人则没有。虽然回应是 异质性显然是由基因决定的，对分子途径和机制知之甚少。 这有助于适应急性运动和运动训练。分子换能器的发展目标 体力活动联合会(MoTrPAC)的目标是“了解在 体力活动“。因此，我们建议进行一项随机临床试验，在该试验中，我们将收集生物 12周有氧或阻力训练前后的样本(血液、骨骼肌和脂肪组织) 该计划适用于健康、久坐的个人。此外，我们将在单打之前、期间和之后收集样本 在基线和训练结束后进行一轮锻炼。我们还将收集训练有素的运动员的生物样本 参加耐力或力量运动。该计划的首要目标是为 开发作为体力活动影响基础的传感器的分子图谱。 为了实现这一目标，彭宁顿生物医学研究中心的研究人员提议： 1)招募518名健康但久坐不动的志愿者(50%高加索人，47.5%非洲人 美国人，2.5%其他人；年龄21-75岁；体重指数20-40公斤/平方米)在3/3/1方案到12周的干预试验中 由有氧(AER)和耐力(RES)两个运动组和一个对照组(CON)组成。 目标是每个训练组有178名完成者，CON组有60名完成者(20%的自然减员)。 2)招收50名参加耐力和力量项目的运动员(ATH)服务 作为一个积极的控制组。ATH组将接受基线测试和一次急性运动 与他们的正常训练方案一致，在急性运动前和急性后收集类似的样本。 AER计划将从每周3天的跑步机步行/跑步开始，到2010年将进展到每周4天 第2周，开始中等强度(心率与50%VO2峰值相关)，然后增加到更多 运动强度(HR 75%VO2峰值)到第6周。每周3天进行RES计划，并 包括9个环球健身器材的练习，包括4个上半身提举，3个下半身提举， 腹部痉挛和背部伸展。Res计划将从2组10-20次重复进行到3次 在第二周之后，每组8-10次重复。所有的AER和RES练习都将在严格的 由训练有素的工作人员监督。由于培训研究和翻译研究方面的专业知识以及 由于拥有最先进的设施，宾宁顿调查人员处于有利地位，可以招聘/保留一名 进行拟议的试验，并收集/储存必要的生物样本。