Pennington MoTrPAC Adults

彭宁顿 MoTrPAC 成人

• 批准号: 10391629
• 负责人: Tuomo Rankinen
• 金额: $ 3.2万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391629
• 关键词: 21 year old; Abdomen; Acute; Adipose tissue; Adult; Aerobic; Aerobic Exercise; African American; Back; Biological; Biology; Biomedical Research; Biopsy; Blood; Body Composition; Body mass index; Caucasians; Cell Culture Techniques; Clinical Trials; Collection; Control Groups; Data; Development; Disease; Enrollment; Equipment; Exercise; General Population; Genetic; Goals; Health; Health Promotion; Heart Rate; Heritability; Heterogeneity; Human; Individual; Individual Differences; Intervention; Intervention Trial; Life Style; Lifting; Maps; Measures; Molecular; Morbidity - disease rate; Multicenter Studies; Muscle; Muscle Fibers; Participant; Pathway interactions; Performance; Physical activity; Population Heterogeneity; Positioning Attribute; Randomized; Randomized Clinical Trials; Recommendation; Regimen; Research; Research Personnel; Resistance; Rest; Risk Factors; Running; Sampling; Scheme; Skeletal Muscle; Specimen; Sports; Supervision; Testing; Training; Training Programs; Transducers; Translational Research; Vision; Walking; active control; aged; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; exercise intervention; exercise training; experience; healthy lifestyle; improved; intervention participants; mortality; muscle strength; novel; precision medicine; programs; recruit; resistance exercise; response; sample collection; sedentary; skills; strength training; success; treadmill; treatment arm; vigorous intensity; volunteer

PROJECT SUMMARY ABSTRACT A considerable body of evidence shows that exercise training induces multiple beneficial changes in cardiometabolic risk factors and that physically active individuals have lower mortality and morbidity rates than their sedentary counterparts. However, there are marked inter-individual differences in the responsiveness to regular physical activity with some individuals showing great benefits while others do not. While the response heterogeneity is clearly genetically determined, little is known about the molecular pathways and mechanisms that contribute to the adaptation to acute exercise and exercise training. The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to “understand the molecular changes that occur in response to physical activity”. We therefore propose to conduct a randomized clinical trial in which we will collect biological samples (blood, skeletal muscle and adipose tissue) before and after a 12-week aerobic or resistance training program in healthy, sedentary individuals. In addition, we will collect samples before, during and after a single bout of exercise at baseline and after training. We will also collect biosamples in highly trained athletes involved in endurance or strength sports. The overarching goal of the program is to contribute to the development of a molecular map of transducers that underlie the effects of physical activity. To achieve this goal, investigators at the Pennington Biomedical Research Center propose to: 1) Enroll and randomize 518 healthy, but sedentary volunteers (50% Caucasians, 47.5% African Americans, 2.5% others; aged 21-75 y; BMI 20-40 kg/m2) in a 3/3/1 scheme to a 12-week intervention trial comprised of two exercise groups, aerobic (AER) and resistance (RES) training, and a control group (CON). The goal is to have 178 completers in each training group and 60 in the CON group (20% attrition). 2) Recruit and enroll 50 athletes (ATH) competing in endurance (n=25) and strength (n=25) sports to serve as an active control group. The ATH group will undergo baseline testing and an acute bout of exercise consistent with their normal training regimen with similar pre- and post-acute exercise samples collection. The AER program will start at 3 days per week of treadmill walking/running progressing to 4 days per week by week 2 with an initial moderate intensity (heart rate associated with 50% VO2peak), then increasing to a more vigorous intensity (HR 75% VO2peak) by week 6. The RES program will be performed 3 days per week and consist of 9 exercises on Universal Gym Equipment, including four upper body lifts, three lower body lifts, abdominal crunch, and back extensions. The RES program will progress from 2 sets of 10-20 repetitions to 3 sets of 8-10 repetitions after week 2. All AER and RES exercise sessions will be conducted under strict supervision by trained staff. Because of the expertise in training studies and translational research as well as the availability of state-of-the-art facilities, Pennington investigators are well positioned to recruit/retain a diverse population, conduct the proposed trial and collect/store the necessary biosamples.

项目概要 抽象的 大量证据表明，运动训练可以引起多种有益的变化 心脏代谢危险因素以及体力活动人群的死亡率和发病率低于 他们久坐的同行。然而，个体之间的反应程度存在显着差异。 定期进行体育锻炼对某些人有很大好处，而另一些人却没有。虽然回应 异质性显然是由基因决定的，但对其分子途径和机制知之甚少 这有助于适应急性运动和运动训练。分子传感器的目标 体力活动联盟 (MoTrPAC) 的目标是“了解因响应而发生的分子变化” 体力活动”。因此，我们建议进行一项随机临床试验，其中我们将收集生物 12 周有氧或阻力训练前后的样本（血液、骨骼肌和脂肪组织） 针对健康、久坐的人的计划。此外，我们将在单次之前、期间和之后收集样本 基线和训练后的锻炼。我们还将收集训练有素的运动员的生物样本 参与耐力或力量运动。该计划的总体目标是为 开发作为身体活动影响基础的传感器分子图。 为了实现这一目标，彭宁顿生物医学研究中心的研究人员建议： 1) 招募并随机分配 518 名健康但久坐的志愿者（50% 为白人，47.5% 为非洲人） 美国人，2.5%其他；年龄21-75岁； BMI 20-40 kg/m2）在 3/3/1 方案中进行 12 周干预试验 由两个运动组组成：有氧（AER）和阻力（RES）训练，以及对照组（CON）。 目标是每个训练组有 178 名完成者，CON 组有 60 名完成者（20% 流失）。 2) 招募并招收 50 名运动员（ATH），参加耐力赛（n=25）和力量赛（n=25）项目的比赛 作为主动对照组。 ATH 组将接受基线测试和剧烈运动 与他们的正常训练方案一致，并收集类似的急性运动前和运动后样本。 AER 计划将从每周 3 天的跑步机步行/跑步开始，逐渐发展到每周 4 天 第 2 周，初始强度中等（心率与 50% VO2peak 相关），然后增加至更高强度 第 6 周时进行剧烈强度（HR 75% VO2peak）。RES 计划将每周进行 3 天，并且 包含 9 项通用健身器材练习，其中包括 4 项上半身提升、3 项下半身提升、 腹部卷腹和背部伸展。 RES 计划将从 2 组 10-20 次重复进展到 3 组 第 2 周后进行 8-10 组重复。所有 AER 和 RES 锻炼课程都将在严格的条件下进行 由经过培训的人员进行监督。由于培训研究和转化研究方面的专业知识以及 由于拥有最先进的设施，彭宁顿调查人员能够很好地招募/留住 不同的人群，进行拟议的试验并收集/存储必要的生物样本。