Patient-oriented research and mentoring in preterm birth toxicogenomics

以患者为中心的早产毒理基因组学研究和指导

• 批准号: 10321533
• 负责人: TRACY A. MANUCK
• 金额: $ 16.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10321533
• 关键词: Address; Advisory Committees; Air Pollution; Award; Biological Assay; Biological Markers; Biological Monitoring; Biometry; Caring; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Complement; Complex; Complex Mixtures; Data; Diabetes Mellitus; Diet; Educational workshop; Effectiveness; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Epigenetic Process; Exposure to; Faculty; Fellowship; Fetal Growth Retardation; Funding; Future; Gene Expression; Genetic; Genotype; Goals; Grant; Health; High Risk Woman; Home; Human; Inflammation; Inflammatory; Institutes; Knowledge; Leadership; Maternal Messenger RNA; Maternal-fetal medicine; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Mission; Monitor; Mutation; National Institute of Environmental Health Sciences; Neonatology; Nitric Oxide Pathway; North Carolina; Patient Self-Report; Pharmacogenomics; Phase; Physicians; Placenta; Play; Postdoctoral Fellow; Pregnancy; Pregnant Women; Premature Birth; Prevention therapy; Progesterone; Recruitment Activity; Recurrence; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Role; Scientist; Serum; Statistical Methods; Surveys; Survivors; Testing; Time; Toxic Environmental Substances; Toxicogenomics; Training; Training Programs; Translational Research; United States National Institutes of Health; Urine; Woman; Work; Writing; career; career development; cohort; disability; drinking water; early pregnancy; gene environment interaction; global health; high risk; improved; indexing; instructor; metal metabolism; mortality; multidimensional data; multidisciplinary; neonate; next generation; patient oriented research; premature; prevent; prospective; psychosocial; racial disparity; recruit; response; skills; social; toxicant; training opportunity

PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.

项目摘要 这个K24建议建立在十多年的临床和转化研究的基础上-候选人-博士。 Tracy Manuck，MD，MSc，专注于自发性早产（SPTB）。在这个应用程序中，Manuck博士 招募了一个多学科的教师专家团队来合作，并支持她在这奋进，一个 反映了环境研究的广度和深度。这项工作将大大增强她的能力。 目前的投资组合在以病人为导向的研究，使她能够扩大她目前的工作，并纳入 环境污染物进入她目前的R 01资助的研究（R 01-MD 011609），创造了一个丰富的，多- 多维数据集。候选人：Manuck博士是SPTB药物基因组学领域公认的思想领袖。 她赢得了无数的国家荣誉，并领导了高影响力的临床早产研究;在这里，她寻求 通过将毒理基因组学纳入她的研究来补充这些技能。指导计划/环境： 博士Manuck在研究培训方面有着良好的记录，包括担任母婴医学博士。 (MFM)研究金研究主任和2个研究生水平赠款写作课程的小组讲师， 研究员和初级教员。然而，行政和临床职责的竞争限制了她的可用时间 做导师K24奖励支持将在早产儿中实现更全面的指导组合， 帮助培养足够数量的研究人员，调查环境对生殖健康的影响， 这是该领域迫切需要的污染物暴露。在K24的支持下，她将有适当的时间 以及指导高级学员的资源（例如，博士后研究员，初级教师）在他们的追求， 独立融资。Manuck博士将利用IBM的广泛资源来实现这一目标，包括 NIH资助的中心和培训计划，网络和合作，以及全球卫生机构。职业生涯 目标和目的：Manuck博士将完成以下职业发展目标，包括： 目标1 -扩大环境卫生知识;职业目标2 -提高指导技能;职业目标3 - 增强科技成果传播能力。研究计划：Manuck博士将利用她的R 01研究 （目前正在招募），以评估暴露于促炎性环境污染物作为 SPTB的额外关键驱动程序。她将在整个研究目标中整合导师制：目标1 -量化曝光 通过自我报告和对孕妇尿液，血清， 目的2 -确定哪种污染物或污染物组合与胎盘的相关性最强 目标3 -测试基因x环境相互作用对复发性SPTB风险的影响。这个计划 为Manuck博士的培训提供了一个框架， 研究，可能对美国每年过早分娩的> 45万名婴儿产生终身影响， 同时提供一个平台，指导未来的研究人员致力于以病人为导向的研究。