Patient-oriented research and mentoring in preterm birth toxicogenomics

项目总结 这份K24提案建立在十多年的临床和翻译研究的基础上--候选人--Dr。 特蕾西·曼努克，医学博士，理学硕士，一直专注于自发早产(SPTB)。在这个应用程序中，Manuck博士有 招募了一支由多学科教师专家组成的团队，在这一努力中合作和支持她，这一努力 反映了北卡罗来纳大学在环境研究方面资源的广度和深度。这项工作将极大地增强她的能力 目前以患者为导向的研究组合，使她能够扩大目前的工作并将 将环境污染物纳入她目前由R01资助的研究(R01-MD011609)，创建了丰富、多 维度数据集。候选人：马努克博士是公认的SPTB药物基因组学思想领袖。 她赢得了许多国家的赞誉，并领导了高影响力的临床早产研究；在这里，她寻求 通过将毒素基因组学纳入她的研究来补充这些技能。指导计划/环境： Manuck博士在研究培训方面有既定的记录，包括担任母胎医学 (MFM)研究金研究主任和一名小组讲师，负责2个研究生级别的补助金写作课程 研究员和初级教员。然而，相互竞争的行政和临床责任限制了她的可用时间 作为导师。K24奖励支持将在早熟期间实现更全面的指导组合，以及 帮助培养一批研究环境对生殖健康影响的研究人员 这一领域迫切需要污染物暴露。有了K24支持，她将有适当的时间 和资源，以指导高级实习生(例如，博士后研究员、初级教员)追求 独立资助。马努克博士将利用北卡罗来纳大学的广泛资源来实现这一目标，包括 美国国立卫生研究院资助的中心和培训项目、网络和合作以及全球卫生机构。职业生涯 目标和目标：马努克博士将实现以下职业发展目标，包括：职业 目标1-扩大环境健康知识；职业目标2-提高指导技能；职业目标3- 增强科技成果传播能力。研究计划：Manuck博士将利用她的R01研究 (目前正在招聘)评估暴露在促炎环境污染物中的影响 SPTB的其他关键驱动因素。她将在研究目标中整合指导：目标1-量化暴露 通过自我报告和对母亲尿液、血清、 和胎盘；目标2-确定哪种污染物或污染物组合最相关 以及目标3-测试基因x环境交互作用对复发SPTB风险的影响。这个计划 为Manuck博士在将环境污染物纳入早产儿方面的培训提供了一个框架 研究可能会对美国每年早产的45万名婴儿产生终身影响，而 同时为指导未来致力于以患者为中心的研究提供一个平台。

PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.