课题基金 / 基金详情

Patient-oriented research and mentoring in preterm birth toxicogenomics

Patient-oriented research and mentoring in preterm birth toxicogenomics
以患者为中心的早产毒理基因组学研究和指导
批准号:
10542363
负责人:
TRACY A. MANUCK
金额:
$16.36万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-01-15 至 2025-12-31
关键词:
AddressAdvisory CommitteesAir PollutionAwardBiological AssayBiological MarkersBiological MonitoringBiometryCaringChemicalsClinicalClinical ResearchCollaborationsCommunitiesComplementComplexComplex MixturesDataDiabetes MellitusDietDimensionsEducational workshopEffectivenessEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental ImpactEnvironmental PollutantsEpigenetic ProcessExposure toFacultyFellowshipFetal Growth RetardationFundingFutureGene ExpressionGeneticGenotypeGoalsGrantHealthHigh Risk WomanHomeHumanInflammationInflammatoryKnowledgeLeadershipMaternal Messenger RNAMaternal-fetal medicineMeasuresMentorsMentorshipMethodologyMethodsMid-Career Clinical Scientist Award (K24)MissionMonitorMutationNational Institute of Environmental Health SciencesNeonatologyNitric Oxide PathwayNorth CarolinaPatient Self-ReportPharmacogenomicsPhasePhysiciansPlacentaPlayPostdoctoral FellowPregnancyPregnant WomenPremature BirthPrevention therapyProgesteroneRecruitment ActivityRecurrenceReproductive HealthResearchResearch PersonnelResearch Project GrantsResearch TrainingResourcesRiskRisk FactorsRisk ReductionRoleScientistSerumStatistical MethodsSurveysSurvivorsTestingTimeToxic Environmental SubstancesToxicogenomicsTrainingTraining ProgramsTranslational ResearchUnited States National Institutes of HealthUrineWomanWorkWritingcareercareer developmentcohortdisabilitydrinking waterearly pregnancygene environment interactionglobal healthhigh riskimprovedindexinginstructormetal metabolismmortalitymultidimensional datamultidisciplinaryneonatenext generationpatient oriented researchprematurepreventprospectivepsychosocialracial disparityrecruitrelapse preventionresponseskillssocialtoxicanttraining opportunity

项目摘要

项目成果

TRACY A. MANUCK的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.
期刊论文(14)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.ajogmf.2021.100308
发表时间: 2021-05
期刊: American journal of obstetrics & gynecology MFM
影响因子: 6.3
作者: [Stone J, Sutrave P, Gascoigne E, Givens MB, Fry RC, Manuck TA]
通讯作者: Manuck TA
DOI: 10.1016/j.ajogmf.2021.100353
发表时间: 2021-07
期刊: American journal of obstetrics & gynecology MFM
影响因子: 6.3
作者: [Green CA, Johnson JD, Vladutiu CJ, Manuck TA]
通讯作者: Manuck TA
DOI: 10.1001/jamanetworkopen.2023.46314
发表时间: 2023-12-01
期刊: JAMA NETWORK OPEN
影响因子: 13.8
作者: [Kucirka, Lauren M., Angarita, Ana M., Manuck, Tracy A., Boggess, Kim A., Derebail, Vimal K., Wood, Mollie E., Meyer, Michelle L., Segev, Dorry L., Reynolds, Monica L.]
通讯作者: Reynolds, Monica L.
DOI: 10.1016/j.ajogmf.2020.100229
发表时间: 2020-11
期刊: American journal of obstetrics & gynecology MFM
影响因子: 6.3
作者: [Traylor CS, Johnson JD, Kimmel MC, Manuck TA]
通讯作者: Manuck TA
9
    Patient-oriented research and mentoring in preterm birth toxicogenomics
    The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black Women
    The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black Women
    Pharmacogenomics of Preterm Birth Prevention and Treatment
    海外基金