The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome

人类肠道微生物组内复杂碳水化合物生物合成和降解的新代谢途径的发现

基本信息

  • 批准号:
    10323657
  • 负责人:
  • 金额:
    $ 60.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-02-01 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

The primary focus of this research proposal is the discovery and elucidation of novel biochemical pathways for the biosynthesis and metabolism of complex and simple carbohydrates in the human gut microbiome. The total number of genes contained within the distinct bacterial species that inhabit the human gut exceeds the number of human genes by more than two orders of magnitude. The metabolic diversity within these bacteria contributes significantly to the maintenance of human health and physiology. Unfortunately, a significant fraction of the enzymes and metabolic pathways contained within the bacterial species localized in the human gut have an uncertain, unknown, or incorrect functional annotation. This uncertainty demonstrates that a substantial fraction of the metabolic potential found within the human gut microbiome remains to be properly characterized. The experimental approach for the discovery and elucidation of novel biochemical pathways for the metabolism of complex carbohydrates will employ the concerted and synergistic utilization of computational biology, bioinformatics, three-dimensional protein structure determination, metabolomics, and physical screening of focused compound libraries. This investigation will further be directed towards a complete understanding of the assembly and biosynthesis of the diverse capsular polysaccharides in the human pathogen Campylobacter jejuni, the leading cause of human gastroenteritis world-wide. The capsular polysaccharides are important for the invasion and colonization of the host organism and the monosaccharides that comprise the CPS in various strains of C. jejuni are unusual and complex. This endeavor will focus on the elucidation of the molecular pathways for the biosynthesis of the unusual array of monosaccharide building blocks and the associated molecular logic for the directed assembly of unique polysaccharide sequences by a series of sugar transferase enzymes. The determination of the substrate and reaction diversity contained within these newly discovered enzyme-catalyzed reactions will provide unique insights into the molecular mechanisms for the evolution and development of novel enzymatic activities and will provide potential targets for therapeutic intervention.
本研究计划的主要焦点是小说的发现和阐明

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Frank M. Raushel其他文献

Catalytic detoxification
催化解毒
  • DOI:
    10.1038/469310a
  • 发表时间:
    2011-01-19
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Frank M. Raushel
  • 通讯作者:
    Frank M. Raushel
The use of phosphotriesterase in the synthesis of enantiomerically pure ProTide prodrugs
磷酸三酯酶在合成对映体纯的前药ProTide中的应用
  • DOI:
    10.1016/j.cbi.2025.111597
  • 发表时间:
    2025-09-05
  • 期刊:
  • 影响因子:
    5.400
  • 作者:
    Andrew N. Bigley;Frank M. Raushel
  • 通讯作者:
    Frank M. Raushel

Frank M. Raushel的其他文献

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{{ truncateString('Frank M. Raushel', 18)}}的其他基金

The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome
人类肠道微生物组内复杂碳水化合物生物合成和降解的新代谢途径的发现
  • 批准号:
    10557076
  • 财政年份:
    2021
  • 资助金额:
    $ 60.6万
  • 项目类别:
The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome
人类肠道微生物组内复杂碳水化合物生物合成和降解的新代谢途径的发现
  • 批准号:
    10084621
  • 财政年份:
    2021
  • 资助金额:
    $ 60.6万
  • 项目类别:
Novel Biochemical Pathways for the Metabolism of Carbohydrates in the Human gut Micriobiome
人类肠道微生物组中碳水化合物代谢的新生化途径
  • 批准号:
    10063528
  • 财政年份:
    2017
  • 资助金额:
    $ 60.6万
  • 项目类别:
Enzymatic Hydrolysis of Organophosphate Esters
有机磷酸酯的酶水解
  • 批准号:
    9235651
  • 财政年份:
    2017
  • 资助金额:
    $ 60.6万
  • 项目类别:
The Enzymology of Phosphonate Metabolism
磷酸盐代谢的酶学
  • 批准号:
    8418217
  • 财政年份:
    2013
  • 资助金额:
    $ 60.6万
  • 项目类别:
The Enzymology of Phosphonate Metabolism
磷酸盐代谢的酶学
  • 批准号:
    8733182
  • 财政年份:
    2013
  • 资助金额:
    $ 60.6万
  • 项目类别:
The Enzymology of Phosphonate Metabolism
磷酸盐代谢的酶学
  • 批准号:
    9113961
  • 财政年份:
    2013
  • 资助金额:
    $ 60.6万
  • 项目类别:
Deciphering Enzyme Specificity: Amidohydrolase Superfamily
破译酶的特异性:酰胺水解酶超家族
  • 批准号:
    7743893
  • 财政年份:
    2009
  • 资助金额:
    $ 60.6万
  • 项目类别:
Amidohydrolase Superfamiily
酰胺水解酶超家族
  • 批准号:
    6854961
  • 财政年份:
    2004
  • 资助金额:
    $ 60.6万
  • 项目类别:
Enzymic Detoxification of Organophosphate Nerve Agents
有机磷神经毒剂的酶解毒
  • 批准号:
    6910693
  • 财政年份:
    2003
  • 资助金额:
    $ 60.6万
  • 项目类别:

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Bone-Adipose Interactions During Skeletal Anabolism
骨骼合成代谢过程中骨-脂肪相互作用
  • 批准号:
    10590611
  • 财政年份:
    2022
  • 资助金额:
    $ 60.6万
  • 项目类别:
Bone-Adipose Interactions During Skeletal Anabolism
骨骼合成代谢过程中的骨-脂肪相互作用
  • 批准号:
    10706006
  • 财政年份:
    2022
  • 资助金额:
    $ 60.6万
  • 项目类别:
Bone-Adipose Interactions During Skeletal Anabolism
骨骼合成代谢过程中骨-脂肪相互作用
  • 批准号:
    10368975
  • 财政年份:
    2021
  • 资助金额:
    $ 60.6万
  • 项目类别:
BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Combined long-acting PTH and calcimimetics actions on skeletal anabolism
BCCMA:针对和抵抗不利于骨骼的条件的基础研究(遏制骨折):长效 PTH 和拟钙剂联合作用对骨骼合成代谢的作用
  • 批准号:
    10365254
  • 财政年份:
    2021
  • 资助金额:
    $ 60.6万
  • 项目类别:
Bone-Adipose Interactions During Skeletal Anabolism
骨骼合成代谢过程中骨-脂肪相互作用
  • 批准号:
    10202896
  • 财政年份:
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  • 资助金额:
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BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Combined long-acting PTH and calcimimetics actions on skeletal anabolism
BCCMA:针对和抵抗不利于骨骼的条件的基础研究(遏制骨折):长效 PTH 和拟钙剂联合作用对骨骼合成代谢的作用
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    10531570
  • 财政年份:
    2021
  • 资助金额:
    $ 60.6万
  • 项目类别:
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剖析与年龄和骨关节炎相关的关节软骨合成代谢下降有关的分子机制
  • 批准号:
    10541847
  • 财政年份:
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剖析与年龄和骨关节炎相关的关节软骨合成代谢下降有关的分子机制
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  • 财政年份:
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    $ 60.6万
  • 项目类别:
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  • 财政年份:
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促进NAD合成代谢以延长寿命
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    DE170100628
  • 财政年份:
    2017
  • 资助金额:
    $ 60.6万
  • 项目类别:
    Discovery Early Career Researcher Award
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