Mobile Assisted Reconstruction In Orthopaedics: extended to the fully automated surgical navigation system

骨科移动辅助重建:扩展到全自动手术导航系统

基本信息

  • 批准号:
    10049308
  • 负责人:
  • 金额:
    $ 68.5万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Collaborative R&D
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

By 2040, 11.4 % of all adults will experience arthritis-attributed activity limitations globally. These limitations lead to pain, social isolation and loneliness. The incidence of disability from knee pain secondary to osteoarthritis is high at 20% of adults over 50 and 40% over 80 years. Total knee arthroplasty (TKA) is one of the most cost-effective and consistently successful surgeries performed to treat osteoarthritis of the knee. Patient-reported outcomes are shown to improve dramatically with respect to pain relief, restoration of function, and improved quality of life. In 2019, around 100,000 and 1,000,000 knee replacements were performed in the UK and the US, respectively. This number is increasing due to demographic and lifestyle changes. However, 10-20% of TKA patients are not fully satisfied, and this is partly attributed to variations in surgery.The advanced technologies that improve the surgery are robotic technologies and patient-specific instrumentation. These are expensive (robots) and difficult to implement (patient-specific instrumentation). By taking advantage of the evolution of smartphone technology, we are developing Mobile Assisted Reconstruction In Orthopaedics (M.A.R.I.O), a simple, low-cost, intra-operative navigation system to help surgeons place implants more precisely.Pre-operative planning is an essential prerequisite for the success of the orthopaedic procedure. We have a developed Statistical Shape Model (SSM) technology that can predict the intact, nonpathological bone shape from X-rays or CT scan images, and we use this to generate a better surgical plan automatically. This plan is utilised by a smartphone-based navigation application during surgery.The segmentation of medical images is a key step before SSM can take place and the current gold standard is to manually draw the region-of-interest. Users' and implant manufacturers' feedback is encouraging us to develop an automated image segmentation tool now, as part of our M.A.R.I.O device. Machine-learning systems are slowly replacing the manual tasks being carried out by medical experts and radiologists with higher accuracy, reduced human effort, and greater speed. The current state-of-the-art research on machine learning-based medical image segmentation at ICL, ICL's world-leading medical device translation infrastructure and the advent of high-speed computers and their modest price is placing us in an ideal position to automate the segmentation of bone and cartilage shapes, which has remained unachieved.The overall cost of the current project is equivalent to 50 revision surgeries, we will prove the feasibility of a fully automated pre-surgical planning software to benefit patients, surgeons, and the NHS in the longer term.
到2040年,全球11.4%的成年人将经历关节炎导致的活动受限。这些限制导致痛苦、社会孤立和孤独。继发于骨关节炎的膝关节疼痛致残的发生率在50岁以上的成年人中为20%,在80岁以上的成年人中为40%。全膝关节置换术(TKA)是治疗膝关节骨关节炎最具成本效益和一贯成功的手术之一。患者报告的结果显示,在疼痛缓解、功能恢复和生活质量改善方面显着改善。2019年,英国和美国分别进行了约10万和100万例膝关节置换术。由于人口和生活方式的改变,这个数字还在增加。然而,10-20%的TKA患者不完全满意,这部分归因于手术的变化。改进手术的先进技术是机器人技术和患者专用仪器。这些都是昂贵的(机器人)和难以实现的(患者专用仪器)。通过利用智能手机技术的发展,我们正在开发一种简单、低成本的手术中导航系统——移动辅助骨科重建(M.A.R.I.O),以帮助外科医生更精确地放置植入物。术前计划是骨科手术成功的必要前提。我们已经开发了统计形状模型(SSM)技术,可以从x射线或CT扫描图像中预测完整的、非病理的骨骼形状,我们使用它来自动生成更好的手术计划。该计划在手术期间由基于智能手机的导航应用程序使用。医学图像的分割是SSM发生之前的关键步骤,目前的黄金标准是手动绘制兴趣区域。用户和植入物制造商的反馈鼓励我们现在开发一种自动图像分割工具,作为我们的M.A.R.I.O设备的一部分。机器学习系统正以更高的准确性、更少的人力和更快的速度慢慢取代医学专家和放射科医生执行的手动任务。ICL目前最先进的基于机器学习的医学图像分割研究,ICL世界领先的医疗设备翻译基础设施和高速计算机的出现及其适中的价格,使我们处于一个理想的位置,可以自动分割骨骼和软骨形状,这仍然是尚未实现的。目前项目的总成本相当于50个翻修手术,我们将证明一个完全自动化的术前计划软件的可行性,从长远来看,这将使患者、外科医生和NHS受益。

项目成果

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其他文献

吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
  • DOI:
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    0
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LiDAR Implementations for Autonomous Vehicle Applications
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
生命分子工学・海洋生命工学研究室
生物分子工程/海洋生物技术实验室
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    0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
  • DOI:
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    0
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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{{ truncateString('', 18)}}的其他基金

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用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    $ 68.5万
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    $ 68.5万
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
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Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
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    2908918
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    2027
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    $ 68.5万
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    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
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    2908693
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    2027
  • 资助金额:
    $ 68.5万
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    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    $ 68.5万
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    $ 68.5万
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    $ 68.5万
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    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
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    2027
  • 资助金额:
    $ 68.5万
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Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
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  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    $ 68.5万
  • 项目类别:
    Studentship

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