Role of basal ganglia in reward-biased visual decisions

基底神经节在奖励偏向视觉决策中的作用

• 批准号: 10328244
• 负责人: LONG DING
• 金额: $ 43.63万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328244
• 关键词: Affect; Basal Ganglia; Basic Science; Behavior; Behavioral; Brain; Cell Nucleus; Clinical; Cognitive; Cognitive deficits; Complex; Computer Models; Data; Data Set; Decision Making; Deep Brain Stimulation; Diagnosis; Diffusion; Disease; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Globus Pallidus; Goals; Health; Impaired cognition; Impairment; Impulsivity; Individual; Knowledge; Link; Methods; Modeling; Monkeys; Motion; Motor; Nature; Nervous system structure; Neurons; Output; Parkinsonian Disorders; Pathway interactions; Patients; Performance; Primates; Probability; Process; Protocols documentation; Reaction Time; Reporting; Research Design; Rewards; Role; Saccades; Signal Transduction; Structure; Structure of subthalamic nucleus; Study models; Substantia nigra structure; Sum; Techniques; Testing; Theoretical model; Time; Training; Visual; Work; addiction; base; caudate nucleus; clinically relevant; cognitive function; electrical microstimulation; expectation; experimental study; flexibility; improved; insight; motivational processes; neurophysiology; novel; oculomotor; oculomotor behavior; preference; relating to nervous system; response; sensory input; statistics; theories

Project Summary The basal ganglia (BG) pathway has been hypothesized to contribute in several important ways to decision- making, including accumulating evidence, controlling decision termination and commitment, transforming abstract decisions to appropriate motor responses, and providing the machinery for evaluating and adjusting the decision performance. However, many of these functions have been proposed in computational modeling studies but have yet to be examined in detail in the brain, leaving important knowledge gaps that seriously impede our ability to understand normal BG function in healthy brains and to diagnose and treat clinical disorders that affect BG function. Our long-term goal is to conduct experiments that allow us to understand the exact nature of the BG pathway's causal contributions to decision-making. Our original project examined the causal roles of the caudate nucleus, an input structure in the BG, in incorporating reward and visual evidence to make saccade decisions. Here we propose to examine the causal roles of two other BG structures, the substantia nigra pars reticulata (SNr, the output structure in the oculomotor BG) and subthalamic nucleus (STN, a BG nucleus with high clinical importance), in decision-making. Guided by predictions of several prominent theoretical models, we combine computational, behavioral, and neurophysiological techniques to examine how SNr (Aim 1) and STN (Aim 2) neurons contribute to decision deliberation and commitment given uncertain visual input alone, and in the context of flexible decisions that must also take into account changes in reward expectation (Aim 3). Results from the proposed project will provide the first direct experimental evidence for how these specific, clinically relevant nuclei contribute to decision-making. These findings will be particularly useful for constraining and informing theories about the neural implementation of decision-making in the primate brain. These findings will also serve as a foundation for investigating the cognitive impairments associated with BG dysfunction.

项目概要 基底神经节（BG）通路被假设以多种重要方式对决策做出贡献： 制定，包括积累证据、控制决策终止和承诺、转变 将决策抽象为适当的运动反应，并提供评估和调整的机制 决策绩效。然而，其中许多函数已在计算建模中提出 研究，但尚未对大脑进行详细检查，留下重要的知识空白，严重影响 妨碍我们了解健康大脑中正常 BG 功能以及诊断和治疗临床疾病的能力 影响 BG 功能的疾病。我们的长期目标是进行实验，让我们了解 BG 通路对决策的因果贡献的确切性质。我们原来的项目经过了检查 尾状核（BG 中的输入结构）在整合奖励和视觉方面的因果作用 做出扫视决策的证据。在这里，我们建议检查另外两个 BG 的因果作用 结构，黑质网状部（SNr，动眼神经 BG 的输出结构）和 丘脑底核（STN，具有高度临床重要性的 BG 核）在决策中的作用。指导者 对几个著名理论模型的预测，我们结合了计算、行为和 用于检查 SNr（目标 1）和 STN（目标 2）神经元如何影响决策的神经生理学技术 仅考虑到不确定的视觉输入，并在灵活决策的背景下进行深思熟虑和承诺 还必须考虑奖励期望的变化（目标 3）。拟议项目的结果将 为这些特定的、临床相关的细胞核如何有助于 决策。这些发现对于约束和告知有关以下问题的理论特别有用： 灵长类动物大脑中决策的神经执行。这些发现也将作为基础 用于研究与 BG 功能障碍相关的认知障碍。