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Role of basal ganglia in reward-biased visual decisions

基底神经节在奖励偏向视觉决策中的作用

基本信息

批准号：
10549357
负责人：
LONG DING
金额：
$ 44.98万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10549357
关键词：
Affect Basal Ganglia Basic Science Behavior Behavioral Brain Cell Nucleus Clinical Cognitive Cognitive deficits Complex Computer Models Data Data Set Decision Making Deep Brain Stimulation Diagnosis Diffusion Disease Foundations Functional Magnetic Resonance Imaging Functional disorder Ganglia Globus Pallidus Goals Health Impaired cognition Impairment Impulsivity Individual Knowledge Link Methods Modeling Monkeys Motion Motor Nature Nervous System Neurons Output Parkinsonian Disorders Pathway interactions Patients Performance Primates Probability Process Protocols documentation Qualifying Reaction Time Reporting Rewards Role Saccades Signal Transduction Structure Structure of subthalamic nucleus Study models Substantia nigra structure Sum Techniques Testing Theoretical model Time Training Visual Work addiction caudate nucleus clinically relevant cognitive function design electrical microstimulation expectation experimental study flexibility improved insight motivational processes neural neurophysiology novel oculomotor oculomotor behavior preference response sensory input statistics theories

项目摘要

Project Summary The basal ganglia (BG) pathway has been hypothesized to contribute in several important ways to decision- making, including accumulating evidence, controlling decision termination and commitment, transforming abstract decisions to appropriate motor responses, and providing the machinery for evaluating and adjusting the decision performance. However, many of these functions have been proposed in computational modeling studies but have yet to be examined in detail in the brain, leaving important knowledge gaps that seriously impede our ability to understand normal BG function in healthy brains and to diagnose and treat clinical disorders that affect BG function. Our long-term goal is to conduct experiments that allow us to understand the exact nature of the BG pathway's causal contributions to decision-making. Our original project examined the causal roles of the caudate nucleus, an input structure in the BG, in incorporating reward and visual evidence to make saccade decisions. Here we propose to examine the causal roles of two other BG structures, the substantia nigra pars reticulata (SNr, the output structure in the oculomotor BG) and subthalamic nucleus (STN, a BG nucleus with high clinical importance), in decision-making. Guided by predictions of several prominent theoretical models, we combine computational, behavioral, and neurophysiological techniques to examine how SNr (Aim 1) and STN (Aim 2) neurons contribute to decision deliberation and commitment given uncertain visual input alone, and in the context of flexible decisions that must also take into account changes in reward expectation (Aim 3). Results from the proposed project will provide the first direct experimental evidence for how these specific, clinically relevant nuclei contribute to decision-making. These findings will be particularly useful for constraining and informing theories about the neural implementation of decision-making in the primate brain. These findings will also serve as a foundation for investigating the cognitive impairments associated with BG dysfunction.

项目总结