Neuronal basis of reward-biased visual perception

奖励偏向视觉感知的神经元基础

• 批准号: 7223705
• 负责人: LONG DING
• 金额: $ 7.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7223705
• 关键词: Affect; Applications Grants; Area; Award; Basal Ganglia; Behavior; Behavioral; Brain; Brain region; Complement; Data; Decision Making; Discrimination; Doctor of Philosophy; Environment; Evaluation; Experimental Models; Eye Movements; Funding; Future; Goals; Gold; Impairment; Individual; Knowledge; Laboratories; Learning; Localized; Mentors; Monkeys; Motion; Neurons; Pathway interactions; Patients; Pennsylvania; Perception; Personal Satisfaction; Phase; Physiology; Preparation; Process; Public Health; Publishing; Rate; Reaction Time; Research; Research Personnel; Resources; Rewards; Role; Saccades; Shapes; Stimulus; System; Techniques; Testing; Time; Training; Universities; Vision; Visual; Visual Fields; Visual Motion; Visual Perception; Work; base; career; data acquisition; design; desire; expectation; experience; frontal eye fields; frontal lobe; improved; innovation; neuromechanism; novel; preference; programs; rapid eye movement; relating to nervous system; research study; skills; visual stimulus

DESCRIPTION (provided by applicant): The objectives of this Pathway to Independence Award for Long Ding, Ph.D., are to expand the candidate's expertise in the field of visual perceptual decision-making and to establish a novel experimental model to fill the knowledge gap on how visual perception is affected by reward-induced internal preferences. Achieving the first objective will complement the candidate's previous training in basal ganglia physiology related to learning and neural representation of reward. Achieving the second objective will provide a launching point for the candidate to develop an independent research career, toward a long-term goal of gaining a better understanding of the basal ganglia functions in reward modulation of perception. These objectives will be accomplished in two phases. In the 2-year mentored phase, the candidate will conduct supervised research in Dr. Joshua Gold's lab at the University of Pennsylvania to identify neural correlates of external evidence-based perceptual decisions in the basal ganglia and frontal cortex, using single-unit recordings in monkeys performing a visual motion discrimination task (Aim 1). This training environment is uniquely suitable because of Dr. Gold's expertise in visual perceptual decision-making, the immediate availability of well-trained monkeys and the intellectual resources available at Penn, which is renowned for its research on vision and perception. In the next 3-year phase, the candidate's independent research will identify neural correlates of decision-making that integrates reward-induced internal preference and external evidence in the basal ganglia and frontal cortex (Aim 2). This research will be based on single unit recordings in monkeys performing a novel visual motion discrimination task that also incorporates reward bias. The proposed research is designed to test the central hypothesis that the neural representations of external evidence and reward-induced internal preference are co-localized and incorporated in individual neurons in the basal ganglia and frontal cortex. It represents an innovative merging of established lines of research and will advance our understanding of the neural mechanisms underlying normal visual perception. Relevance to public health: The proposed research represents an important research area of visual perception and will facilitate future identification of neural targets for better treatment of patients with perceptual impairment.

描述（由申请人提供）：本次独立之路奖的目标是扩展候选人在视觉感知决策领域的专业知识，并建立一个新的实验模型，以填补视觉感知如何受到奖励诱导的内部偏好影响的知识空白。实现第一个目标将补充候选人之前在与学习和奖励神经表征相关的基底神经节生理学方面的训练。实现第二个目标将为候选人发展独立的研究生涯提供一个起点，朝着更好地理解基底神经节在感知的奖励调节中的功能的长期目标。这些目标将分两个阶段实现。在为期2年的指导阶段，候选人将在宾夕法尼亚大学Joshua Gold博士的实验室进行监督研究，以识别基底神经节和额叶皮质中外部循证感知决策的神经相关性，使用执行视觉运动识别任务的猴子的单单元记录（目标1）。这种训练环境是独一无二的，因为戈尔德博士在视觉感知决策方面的专业知识，训练有素的猴子的即时可用性，以及宾夕法尼亚大学以视觉和感知研究而闻名的智力资源。在接下来的3年阶段，候选人的独立研究将在基底神经节和额叶皮层中确定决策的神经相关因素，这些神经相关因素整合了奖励诱导的内部偏好和外部证据（目标2）。本研究将以单个单元为基础