Neuronal basis of reward-biased visual perception

奖励偏向视觉感知的神经元基础

• 批准号: 7323254
• 负责人: LONG DING
• 金额: $ 8.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7323254
• 关键词: Affect; Applications Grants; Area; Award; Basal Ganglia; Behavior; Behavioral; Brain; Brain region; Complement; Data; Decision Making; Discrimination; Doctor of Philosophy; Environment; Evaluation; Experimental Models; Eye Movements; Funding; Future; Goals; Gold; Impairment; Individual; Knowledge; Laboratories; Learning; Localized; Mentors; Monkeys; Motion; Neurons; Pathway interactions; Patients; Pennsylvania; Perception; Personal Satisfaction; Phase; Physiology; Preparation; Process; Public Health; Publishing; Rate; Reaction Time; Research; Research Personnel; Resources; Rewards; Role; Saccades; Shapes; Stimulus; System; Techniques; Testing; Time; Training; Universities; Vision; Visual; Visual Fields; Visual Motion; Visual Perception; Work; base; career; data acquisition; design; desire; expectation; experience; frontal eye fields; frontal lobe; improved; innovation; neuromechanism; novel; preference; programs; rapid eye movement; relating to nervous system; research study; skills; visual stimulus

Project summary: The objectives of this Pathway to Independence Award for Long Ding, Ph.D., are to expand the candidate's expertise in the field of visual perceptual decision-making and to establish a novel experimental model to fill the knowledge gap on how visual perception is affected by reward-induced internal preferences. Achieving the first objective will complement the candidate's previous training in basal ganglia physiology related to learning and neural representation of reward. Achieving the second objective will provide a launching point for the candidate to develop an independent research career, toward a long-term goal of gaining a better understanding of the basal ganglia functions in reward modulation of perception. These objectives will be accomplished in two phases. In the 2-year mentored phase, the candidate will conduct supervised research in Dr. Joshua Gold's lab at the University of Pennsylvania to identify neural correlates of external evidence-based perceptual decisions in the basal ganglia and frontal cortex, using single-unit recordings in monkeys performing a visual motion discrimination task (Aim 1). This training environment is uniquely suitable because of Dr. Gold's expertise in visual perceptual decision-making, the immediate availability of well-trained monkeys and the intellectual resources available at Penn, which is renowned for its research on vision and perception. In the next 3-year phase, the candidate's independent research will identify neural correlates of decision-making that integrates reward-induced internal preference and external evidence in the basal ganglia and frontal cortex (Aim 2). This research will be based on single- unit recordings in monkeys performing a novel visual motion discrimination task that also incorporates reward bias. The proposed research is designed to test the central hypothesis that the neural representations of external evidence and reward-induced internal preference are co-localized and incorporated in individual neurons in the basal ganglia and frontal cortex. It represents an innovative merging of established lines of research and will advance our understanding of the neural mechanisms underlying normal visual perception. Relevance to public health: The proposed research represents an important research area of visual perception and will facilitate future identification of neural targets for better treatment of patients with perceptual impairment.

项目概述：丁龙博士独立之路奖的目标是，要 扩大候选人在视觉感知决策领域的专业知识，并建立一个新的 实验模型，以填补知识差距，对视觉感知是如何影响奖励引起的内部 喜好实现第一个目标将补充候选人以前在基底神经节的训练 与学习有关的生理学和奖赏的神经表征。实现第二个目标将 为候选人提供一个起点，发展独立的研究生涯，走向长期 目的是为了更好地了解基底神经节在奖赏调节知觉中的功能。 这些目标将分两个阶段实现。在为期两年的指导阶段，候选人将 在宾夕法尼亚大学约书亚戈尔德博士的实验室进行监督研究， 相关的外部证据为基础的知觉决定在基底神经节和额叶皮层，使用 单单位记录在猴子执行视觉运动辨别任务（目标1）。本次培训 环境是唯一合适的，因为黄金博士的专业知识，在视觉感知决策， 立即提供训练有素的猴子和宾夕法尼亚大学的智力资源，宾夕法尼亚大学是 以视觉和感知研究而闻名。在接下来的三年里，候选人是独立的 研究将确定决策的神经关联，整合奖励诱导的内部偏好 以及基底神经节和额叶皮层的外部证据（目标2）。这项研究将基于单一的- 在猴子进行一种新的视觉运动辨别任务，也包括单位记录 奖励偏差这项研究的目的是为了验证神经系统的核心假设， 外部证据的表征和奖励诱导的内部偏好是共同定位的， 整合到基底神经节和额叶皮层的单个神经元中。它代表了一种创新的融合 这将促进我们对神经机制的理解， 正常的视觉感知 与公共卫生的相关性：拟议的研究代表了视觉的重要研究领域。 感知，并将有助于未来识别神经靶点，以更好地治疗患有 知觉障碍