New Approaches for Empowering Studies of Asthma in Populations of African Descent

非洲人后裔哮喘研究的新方法

基本信息

  • 批准号:
    10326791
  • 负责人:
  • 金额:
    $ 191.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-28 至 2024-11-30
  • 项目状态:
    已结题

项目摘要

Asthma is a complex disease with striking disparities across racial and ethnic groups, which may be partly attributable to genetic factors. A major goal of the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) has been to discover genes conferring risk to asthma in populations of African ancestry. Genome-wide association studies (GWAS) have been successful in identifying genes associated with increased risk of asthma, but there is a substantial gap between associations discovered by GWAS and understanding how these loci control disease. A major portion of the `missing heritability' could be due to variants with smaller effects missed by traditional GWAS thresholds, emphasizing the need for a transition to integrative genetics, where transcriptome, proteome, methylome and metabolome information are brought into a unified framework. Our goal in this continuing renewal is to apply an integrative, multi-omics approach to understand the molecular architecture underlying asthma, building upon the 5-year CAAPA program, where >16,000 asthmatics and non-asthmatics have already been GWAS-genotyped, and GWAS and/or whole genome sequencing (WGS) data are available on more than 100,000 non-CAAPA samples. We propose to test if genetic variants control development of asthma by regulating gene transcription and expression, DNA methylation, metabolic profiles, and proteome variation. The specific aims of this application leverage an international group of investigators with diverse but highly integrated areas of expertise, and include the following: (1) expand and integrate multi-omic resources for asthma research in African Diaspora populations and identify novel genetic determinants for risk of asthma by adding indigenous American and continental African genetic representation in the African Diaspora catalog, building a multi-omic repository through newly generated transcriptome, methylome, proteome, and metabolome data from CAAPA asthmatics and unaffected controls with existing GWAS data from 7 sites in North and South America, the Caribbean and Africa, and performing integrative analyses; (2) broadly disseminate CAAPA results through a web-based resource that empowers the asthma research community for new discoveries; and (3) develop and apply approaches for prioritizing CAAPA results in 3 health systems biobanks enriched for US minority populations (Nashville, New York City, and the Rocky Mountain region) by examining genomics (PheWAS) and multi-omics (PrediXcan) asthma associations identified in CAAPA and non-CAAPA datasets. These studies will advance our understanding of the molecular basis for asthma among populations of African ancestry.
哮喘是一种复杂的疾病,在不同种族和民族之间存在显著差异, 可能部分归因于遗传因素。哮喘联盟的一个主要目标是 在美洲的非洲血统人口(CAAPA)已经发现基因赋予 非洲血统人群的哮喘风险。全基因组关联研究(GWAS) 已经成功地确定了与哮喘风险增加相关的基因,但 GWAS发现的关联与理解这些基因座如何 控制疾病。“缺失遗传力”的主要部分可能是由于变异较小, 传统GWAS阈值所忽略的影响,强调需要过渡到 整合遗传学,其中转录组,蛋白质组,甲基化组和代谢组信息 被纳入一个统一的框架。我们在这一持续更新中的目标是应用 综合的、多组学的方法来了解哮喘的分子结构, 在为期5年的CAAPA计划的基础上,超过16,000名哮喘患者和非哮喘患者 已经进行了GWAS基因分型,并且GWAS和/或全基因组测序(WGS)数据已 超过100,000个非CAAPA样本。我们打算测试基因变异 通过调节基因转录和表达来控制哮喘的发展 甲基化、代谢谱和蛋白质组变异。具体目标是 应用程序利用了一个国际调查小组, (1)扩大和整合经济和社会理事会的多种资源, 在非洲散居人群中进行哮喘研究,并确定风险的新遗传决定因素 通过在哮喘研究中加入美洲土著和非洲大陆的遗传代表性, 非洲侨民目录,通过新生成的 CAAPA哮喘患者的转录组、甲基化组、蛋白质组和代谢组数据, 未受影响的对照与来自北美和南美7个地点的现有GWAS数据, (2)广泛传播《非洲和加勒比行动计划》, 结果通过基于网络的资源,授权哮喘研究社区的新的 发现;和(3)开发和应用方法,优先CAAPA结果在3健康 为美国少数民族人口(纳什维尔、纽约市和 通过检查基因组学(PheWAS)和多组学(PrediXcan) 在CAAPA和非CAAPA数据集中确定的哮喘相关性。这些研究将进一步 我们对非洲血统人群中哮喘的分子基础的理解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Kathleen C Barnes其他文献

The CD14(−159) polymorphism is not associated with circulating sCD14 nor total serum IgE in an asthmatic population of African descent
  • DOI:
    10.1016/s0091-6749(02)81809-7
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    April Zambelli-Weiner;Bernadatte Gray;Paul N Levett;Raana P Naidu;Kathleen C Barnes
  • 通讯作者:
    Kathleen C Barnes
Body mass index associates with asthma and respiratory symptoms but is not explained by diet in a caucasian isolate
  • DOI:
    10.1016/s0091-6749(02)81811-5
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kathyrn B Held;Rasika A Mathias;Kathleen C Barnes
  • 通讯作者:
    Kathleen C Barnes

Kathleen C Barnes的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Kathleen C Barnes', 18)}}的其他基金

PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseases
PRIDE Academy:血统和性别对肺部疾病组学的影响
  • 批准号:
    10077882
  • 财政年份:
    2019
  • 资助金额:
    $ 191.93万
  • 项目类别:
PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseases
PRIDE Academy:血统和性别对肺部疾病组学的影响
  • 批准号:
    10378108
  • 财政年份:
    2019
  • 资助金额:
    $ 191.93万
  • 项目类别:
Multi-omic studies of asthma severity in an African ancestry population
非洲血统人群哮喘严重程度的多组学研究
  • 批准号:
    10094181
  • 财政年份:
    2018
  • 资助金额:
    $ 191.93万
  • 项目类别:
Multi-omic studies of asthma severity in an African ancestry population
非洲血统人群哮喘严重程度的多组学研究
  • 批准号:
    10331294
  • 财政年份:
    2018
  • 资助金额:
    $ 191.93万
  • 项目类别:
Multi-omic studies of asthma severity in an African ancestry population
非洲血统人群哮喘严重程度的多组学研究
  • 批准号:
    9522470
  • 财政年份:
    2018
  • 资助金额:
    $ 191.93万
  • 项目类别:
New Approaches for Empowering Studies of Asthma in Populations of African Descent
非洲人后裔哮喘研究的新方法
  • 批准号:
    9256781
  • 财政年份:
    2016
  • 资助金额:
    $ 191.93万
  • 项目类别:
A Software Framework for Exploring 1,000 Genomes of African Descent
用于探索 1,000 个非洲人后裔基因组的​​软件框架
  • 批准号:
    9301024
  • 财政年份:
    2015
  • 资助金额:
    $ 191.93万
  • 项目类别:
A Software Framework for Exploring 1,000 Genomes of African Descent
用于探索 1,000 个非洲人后裔基因组的​​软件框架
  • 批准号:
    9096211
  • 财政年份:
    2015
  • 资助金额:
    $ 191.93万
  • 项目类别:
Integrative Genomics in Asthmatics of African Descent
非洲裔哮喘的综合基因组学
  • 批准号:
    9230688
  • 财政年份:
    2014
  • 资助金额:
    $ 191.93万
  • 项目类别:
The autophagic pathway and atopic asthma: role of IL-33 and ST2
自噬途径和特应性哮喘:IL-33 和 ST2 的作用
  • 批准号:
    8811919
  • 财政年份:
    2014
  • 资助金额:
    $ 191.93万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 191.93万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了