Small Animal Studies Core

小动物研究核心

• 批准号: 10328522
• 负责人: Anna M Wu
• 金额: $ 6.27万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328522
• 关键词: Advanced Development; Advisory Committees; Animal Experimentation; Animal Experiments; Animal Model; Animals; Antineoplastic Agents; Bioluminescence; Brain; Breast; Cancer Biology; Cancer Center Support Grant; Cell physiology; City of Hope Comprehensive Cancer Center; Clinic; Clinical; Collaborations; Colorectal; Colorectal Cancer; Computer software; Consult; Consultations; Data; Data Analyses; Data Collection; Development; Diagnosis; Direct Costs; Drug Delivery Systems; Education; Ensure; Equipment; Evaluation; Faculty; Feedback; Fluorescence; Funding; Goals; Grant; Guidelines; Hazardous Substances; Hematologic Neoplasms; Hematopoietic Neoplasms; Hepatocyte; Human; Huntington Disease; IACUC; Image; Imaging Device; Imaging Techniques; Imaging technology; Immune system; ImmunoPET; Immunodeficient Mouse; Individual; Infection; Kidney; Laboratories; Liver; Lung; Maintenance; Medicine; Modeling; Molecular; Molecular Immunology; Monitor; Monoclonal Antibodies; Multimodal Imaging; NCI Center for Cancer Research; Pancreas; Peer Review; Performance; Pharmaceutical Preparations; Physicians; Positron-Emission Tomography; Postdoctoral Fellow; Predisposition; Preparation; Procedures; Prostate; Protocols documentation; Radiation; Radioactive; Radiolabeled; Radionuclide Imaging; Reagent; Reporting; Research; Research Personnel; Research Support; Resource Sharing; Resources; Schedule; Scientist; Services; Solid Neoplasm; Support System; Surveys; System; Techniques; Therapeutic Agents; Toxic effect; Training; Translating; United States National Institutes of Health; Xenograft Model; Xenograft procedure; animal imaging; animal resource; anticancer research; base; cancer immunotherapy; comparative; cost effective; design; drug development; drug metabolism; experimental study; humanized mouse; imaging study; in vivo; in vivo imaging; individual patient; instrument; instrumentation; investigator training; leukemia/lymphoma; lung sarcoma; malignant stomach neoplasm; member; model design; mouse model; neoplastic cell; next generation; novel; operation; optical imaging; organizational structure; patient derived xenograft model; pharmacokinetics and pharmacodynamics; pre-clinical; precision medicine; preclinical study; professor; research and development; response; service delivery; single photon emission computed tomography; square foot; stem cell therapy; targeted agent; theories; theranostics; therapeutic development; translational cancer research; treatment response; tumor; tumor growth

Small Animal Studies Core Shared Resource ABSTRACT The Small Animal Studies Core (SASC) combines the resources available through the previously reviewed Small Animal Imaging Core with a new Animal Tumor Models component. This combined resource provides exceptional quality services for City of Hope Comprehensive Cancer Center (COHCCC) members for basic and translational preclinical studies in cancer biology, anti-cancer drug development, and stem cell therapeutic development. The Small Animal Imaging component of the SASC provides consultation, advanced imaging equipment, imaging services, hands-on training for COHCCC members, and support for protocol and grant preparation. Current systems in the Imaging Laboratory include two units for bioluminescence/fluorescence optical imaging (Ami X and Lago X from Spectral Instruments Imaging) and a PET/SPECT/CT trimodal scanner (Inveon from Siemens). These systems support molecular-based imaging to allow for the monitoring of cellular processes and the non-invasive assessment of pharmacokinetics and pharmacodynamics of therapeutic agents. Often the imaging techniques and targeting agents utilized are directly transferable to the clinical setting. The Animal Tumor Models component of the SASC has established patient-derived xenograft (PDX) models of breast, colorectal, lung, sarcoma, and gastric cancers in collaboration with COHCCC physician scientists and has developed next-generation humanized mouse models for research in cancer immunotherapy and in vivo drug metabolism/toxicity studies. The development of PDX models supports precision medicine by allowing investigators to evaluate tumor growth and therapeutic response for individual patients. The Animal Tumor Models component also provides specialized drug delivery services, training for in vivo procedures, and support for protocol preparation and grant development. The SASC is co-directed by Dr. David Colcher, a Professor in the Department of Molecular Immunology, and Dr. Jun Wu, an Associate Research Professor of Comparative Medicine, and is supported by highly qualified staff that maintain and operate the instrumentation. Oversight is provided by an interdisciplinary faculty Advisory Committee, and user feedback through an annual survey. The SASC occupies three rooms within the 29,000 sq. ft. Parvin Building for animal experiments and two rooms in Huntington Lab for tumor cell and reagent preparation. iLab software is used to schedule services, monitor instrument use, and manage billing within the SASC. Over the previous five years, the SASC was used by 80 unique investigators, including 58 CC members. Of the 58 CC members, 48 (83%) had peer-reviewed funding. As of this report, the SASC provides ongoing support to 12 NIH-funded projects totaling $5.6M per year in direct costs to the COHCCC.

小动物研究核心共享资源 摘要 小动物研究核心（SASC）结合了以前审查过的小动物研究中心提供的资源。 Animal Imaging Core包含新的动物肿瘤模型组件。这一综合资源提供了 为City of Hope Comprehensive Cancer Center（COHCCC）会员提供优质的基本和 癌症生物学、抗癌药物开发和干细胞治疗的转化临床前研究 发展 SASC的小动物成像部分提供咨询，先进的成像设备， 影像服务，COHCCC成员的实践培训，以及对协议和赠款准备的支持。 成像实验室的现有系统包括两个生物发光/荧光光学成像单元 (Ami X和Lago X，来自Spectral Instruments Imaging）和PET/SPECT/CT三模式扫描仪（Inveon，来自 Siemens）。这些系统支持基于分子的成像，以允许监测细胞过程， 治疗药物的药代动力学和药效学的非侵入性评估。往往 所使用的成像技术和靶向剂可直接应用于临床环境。 SASC的动物肿瘤模型部分已经建立了患者来源的异种移植物（PDX）模型， 乳腺癌、结直肠癌、肺癌、肉瘤和胃癌，与COHCCC医生科学家合作， 开发了下一代人源化小鼠模型，用于癌症免疫治疗和体内研究。 药物代谢/毒性研究。PDX模型的开发通过允许 研究者评估个体患者的肿瘤生长和治疗反应。动物肿瘤 模型部分还提供专门的药物输送服务、体内程序培训和支持 用于方案准备和赠款开发。 SASC由分子免疫学系教授大卫科尔彻博士共同指导， 博士吴军是比较医学副研究教授，并得到高素质的支持 维护和操作仪器的人员。监督是由跨学科的教师提供咨询 通过年度调查收集用户反馈。SASC占据了三个房间， 29，000平方米英尺Parvin楼用于动物实验，亨廷顿实验室有两个房间用于肿瘤细胞和试剂 准备. iLab软件用于安排服务、监控仪器使用和管理 SASC。在过去的五年里，SASC被80名独立调查员使用，其中包括58名CC成员。 在58个CC成员中，48个（83%）有同行评审的资金。截至本报告，SASC正在提供 支持12个NIH资助的项目，每年向COHCCC提供560万美元的直接费用。