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Project 3 - Ex vivo immune profiling of dengue viruses and vaccines

Project 3 - Ex vivo immune profiling of dengue viruses and vaccines
项目 3 - 登革热病毒和疫苗的离体免疫分析
批准号：
10330073
负责人：
Ana Fernandez-Sesma
金额：
$15.27万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
已结题
起止时间：
2021-02-11 至 2022-05-31
来源：
https://reporter.nih.gov/project-details/10330073
关键词：
2019-nCoVAddressAdministrative SupplementAdultCOVID-19 pandemicChildDengue VaccineEnrollmentEpidemiologyFundingHealthHouseholdHumanImmuneLung diseasesMonitorNational Institute of Allergy and Infectious DiseaseParticipantPediatric ResearchPopulationSerologySurveysTestingUnited States National Institutes of Healthdesignepidemiologic datainfection burdeninfection ratememberprospectiveresearch studyresponse

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中文摘要
翻译
新冠肺炎疫情是美国民众在一年内面临的最重要的健康挑战 世纪。大多数流行病学数据都集中在导致严重呼吸道疾病的病例上。 主要见于成人的疾病。关于#年感染负担的信息不足 儿童是可以获得的，特别是在预期受到监测的家庭的背景下 通过重复测试。此信息对于确定静默和有症状的 儿童感染率。NIAID支持的人类流行病学和SARS应对措施- CoV-2(HEROS)调查研究旨在填补这一空白。
英文摘要
The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available, especially in the context of households that are prospectively monitored with repetitive testing. This information is critical to determine the silent and symptomatic infection rate in children. The NIAID-supported Human Epidemiology and Response to SARS- CoV-2 (HEROS) survey study is designed to fill this gap.
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Immune Phenotyping Core
Immune phenotyping of human immune responses to dengue vaccination and challenge
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)
Administrative Core
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