Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)
病毒免疫和疫苗接种 (VIVA) 人类免疫学项目联盟 (HIPC)
基本信息
- 批准号:10435231
- 负责人:
- 金额:$ 226.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-22 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAreaArgentinaAttenuatedBioinformaticsBiological AssayBiological ModelsCOVID-19 pandemicCOVID-19 vaccinationCOVID-19 vaccineCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCharacteristicsClinicalClinical TrialsCollaborationsCommunicable DiseasesCommunitiesCouplingCryopreserved CellDataData AnalysesData SetDengueDengue VaccineDengue VirusDevelopmentDifferentiation AntigensEnsureEnzyme-Linked Immunosorbent AssayEpidemicFlow CytometryFoundationsFrequenciesGenbankGenerationsGenomic approachGenomicsGoalsHumanImmuneImmune responseImmune systemImmunityImmunizationImmunoglobulinsImmunologic MemoryImmunologicsImmunologyIndividualInfectionInfluenza A virusInfluenza B VirusInfluenza vaccinationInvestigationLongitudinal cohortLymphoid TissueMaintenanceMapsMeasuresMediatingMetadataMethodsModelingMorbidity - disease ratePathway interactionsPeripheral Blood Mononuclear CellPhenotypePhysiciansPhysiologicalPlasmaPopulationPopulation CharacteristicsPrevention strategyPublic HealthResearch PersonnelRespiratory Tract InfectionsSARS coronavirusSamplingScientistSerologySerotypingSourceStandardizationSystemTechniquesTechnologyTestingTimeTissuesTonsilVaccinatedVaccinationVaccineeVaccinesValidationViralViral AntigensViral PathogenesisVirusVirus DiseasesWorld Healthadaptive immune responseadaptive immunitybreakthrough infectioncell typecohortdata infrastructuredata managementdata miningdata repositorydata standardsdata toolsexperimental studygene networkgenomic dataholistic approachhuman diseaseimmunological statusin vivoinfluenza infectioninfluenza virus vaccineinfluenzavirusmortalitymosquito-bornenetwork modelsnext generationnovelpathogenpathogenic virusphenotypic datapredictive modelingprogramsresponseseasonal influenzasequencing platformtooltranscriptomicsvaccination outcomevaccine candidatevaccine immunogenicityvaccine responsevaccine trialvaccinologyvirology
项目摘要
SUMMARY
The Viral Immunity and Vaccination (VIVA) Human Immunology Project Consortium (HIPC) will carry out a
comprehensive systems immunology program to assess the dynamic human immune response to SARS-CoV-
2, seasonal influenza viruses and tetravalent and trivalent dengue vaccines and subsequent infections by those
pathogens. It will generate comprehensive innate, cellular and adaptive immune signatures that correlate with
vaccine outcomes. The VIVA HIPC will leverage recent advances in human immune profiling methods to
characterize the diverse states of the human immune system before and after vaccination against these viral
pathogens of great public health concern using novel immune phenotyping and genomics strategies that
generate data and tools to be used for downstream data analysis and functional investigations. The proposed
studies will use longitudinal biospecimens from established human cohorts of respiratory infections and
vaccinations in the US and Argentina as well as from vaccine trials in the US (provided by the Clinical Core,
Core B). In addition, validation experiments using human tonsils sourced from healthy individuals and exposed
ex vivo to the different vaccine types will be conducted. Three complementary, well-integrated projects will
produce in-depth human immune profiles and signatures of SARS-CoV-2 vaccinations and infections (Project
1), seasonal influenza vaccinations and infections (Project 2) as well as dengue vaccine and human challenge
studies (Project 3). Unique in our approach is the use of longitudinal cohorts for in vivo profiling, supported by
ex vivo human tonsillar histoculture (HC) models for infection and vaccination. Our holistic approach will provide
cutting- responses to
vaccinations and infections by the Immune Phenotyping Core (Core C), genomics/transcriptomics, including
scRNAseq, CITEseq and spatial tissue transcriptomics by the Genomics Core (Core D), and experimental
vaccinations in primary human tonsillar histocultures (HC) in Projects 1, 2 and 3. Data mining, bioinformatics
to identify the network
components and infer their interactions and correlations important for vaccine outcomes will be done by the Data
management and Analysis Core (Core E). The VIVA HIPC will make the data, analyses and immune profiles
generated available to the scientific community by coupling our local data infrastructure to ImmPort (directly or
through the HIPC Coordinating Center). This integration will ensure full and timely release of clinical, sample,
and experimental metadata in synchrony with genomic data releases to standard data repositories including
SRA, GEO, and Genbank (Core E). The VIVA team (Drs. Krammer, Garcia-Sastre, Durbin, Gamarnik, van
Bakel and Sebra) led by Dr. Fernandez-Sesma and Dr. Simon includes physicians, physician scientists and
scientists with complementary expertise in viral immunology, viral pathogenesis, vaccinology, genomics,
data analysis and a proven track record of collaboration and excellence.
摘要
病毒免疫和疫苗接种(VIVA)人类免疫学项目联盟(HIPC)将开展
全面的系统免疫学计划,以评估人类对SARS冠状病毒的动态免疫反应
2、季节性流感病毒和四价和三价登革热疫苗以及这些疫苗随后的感染
病原体。它将产生全面的先天、细胞和适应性免疫特征,这些特征与
疫苗结果。Viva HIPC将利用人类免疫图谱方法的最新进展来
描述接种这些病毒疫苗前后人类免疫系统的不同状态
使用新的免疫表型和基因组学策略
生成用于下游数据分析和功能调查的数据和工具。建议数
研究将使用来自已建立的呼吸道感染和人类感染队列的纵向生物菌群
美国和阿根廷的疫苗接种以及美国的疫苗试验(由临床核心提供,
核心B)。此外,使用人类扁桃体的验证实验来自健康人并暴露在
将对不同的疫苗类型进行体外试验。三个相辅相成、整合良好的项目将
制作深入的人类免疫档案和SARS-CoV-2疫苗接种和感染签名(项目
1)、季节性流感疫苗接种和感染(项目2)以及登革热疫苗和人类挑战
研究(项目3)。我们方法的独特之处在于使用纵向队列进行活体分析,支持
体外人扁桃体组织培养(HC)感染和疫苗接种模型。我们的整体方法将提供
削减-响应于
免疫表型核心(核心C)的疫苗接种和感染,基因组学/转录组学,包括
ScRNAseq、CITEseq和基因组核心(核心D)的空间组织转录组学,以及实验
项目1、2和3中的原代人类扁桃体组织培养(HC)中的疫苗接种。数据挖掘,生物信息学
识别网络
并推断它们的相互作用和对疫苗结果重要的相关性将通过数据来完成
管理和分析核心(核心E)。Viva HIPC将制作数据、分析和免疫档案
通过将我们的本地数据基础设施连接到ImmPort(直接或
通过重债穷国协调中心)。这一集成将确保充分和及时地发布临床、样本、
以及与向标准数据存储库发布基因组数据同步的实验元数据,包括
SRA、GEO和Genbank(核心E)。万岁团队(Krammer,Garcia-Sastre,Durbin,Gamarnik,Van
Bakel和Sebra)由Fernandez-Sesma博士和Simon博士领导,包括医生、内科科学家和
在病毒免疫学、病毒发病机制、疫苗学、基因组学、
数据分析以及经过验证的协作和卓越记录。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ana Fernandez-Sesma其他文献
Ana Fernandez-Sesma的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ana Fernandez-Sesma', 18)}}的其他基金
Immune phenotyping of human immune responses to dengue vaccination and challenge
人类对登革热疫苗接种和攻击的免疫反应的免疫表型
- 批准号:
10595650 - 财政年份:2022
- 资助金额:
$ 226.57万 - 项目类别:
Immune phenotyping of human immune responses to dengue vaccination and challenge
人类对登革热疫苗接种和攻击的免疫反应的免疫表型
- 批准号:
10435238 - 财政年份:2022
- 资助金额:
$ 226.57万 - 项目类别:
Viral Immunity and VAccination (VIVA) Human Immunology Project Consortium (HIPC)
病毒免疫和疫苗接种 (VIVA) 人类免疫学项目联盟 (HIPC)
- 批准号:
10595622 - 财政年份:2022
- 资助金额:
$ 226.57万 - 项目类别:
Project 3 - Ex vivo immune profiling of dengue viruses and vaccines
项目 3 - 登革热病毒和疫苗的离体免疫分析
- 批准号:
10330073 - 财政年份:2021
- 资助金额:
$ 226.57万 - 项目类别:
Administrative Supplement for the HEROS Study Serology
HEROS 研究血清学的行政补充
- 批准号:
10311727 - 财政年份:2021
- 资助金额:
$ 226.57万 - 项目类别:
Dengue Human Immunology Project Consortium (DHIPC)
登革热人类免疫学项目联盟 (DHIPC)
- 批准号:
10056684 - 财政年份:2020
- 资助金额:
$ 226.57万 - 项目类别:
相似国自然基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
- 批准号:2021JJ40433
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
- 批准号:32001603
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
AREA国际经济模型的移植.改进和应用
- 批准号:18870435
- 批准年份:1988
- 资助金额:2.0 万元
- 项目类别:面上项目
相似海外基金
Onboarding Rural Area Mathematics and Physical Science Scholars
农村地区数学和物理科学学者的入职
- 批准号:
2322614 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant
TRACK-UK: Synthesized Census and Small Area Statistics for Transport and Energy
TRACK-UK:交通和能源综合人口普查和小区域统计
- 批准号:
ES/Z50290X/1 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Research Grant
Wide-area low-cost sustainable ocean temperature and velocity structure extraction using distributed fibre optic sensing within legacy seafloor cables
使用传统海底电缆中的分布式光纤传感进行广域低成本可持续海洋温度和速度结构提取
- 批准号:
NE/Y003365/1 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Research Grant
Point-scanning confocal with area detector
点扫描共焦与区域检测器
- 批准号:
534092360 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Major Research Instrumentation
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326714 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326713 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant
Unlicensed Low-Power Wide Area Networks for Location-based Services
用于基于位置的服务的免许可低功耗广域网
- 批准号:
24K20765 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427233 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant
Postdoctoral Fellowship: OPP-PRF: Tracking Long-Term Changes in Lake Area across the Arctic
博士后奖学金:OPP-PRF:追踪北极地区湖泊面积的长期变化
- 批准号:
2317873 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427232 - 财政年份:2024
- 资助金额:
$ 226.57万 - 项目类别:
Standard Grant














{{item.name}}会员




