Administrative Supplement for the HEROS Study Serology

HEROS 研究血清学的行政补充

• 批准号: 10311727
• 负责人: Ana Fernandez-Sesma
• 金额: $ 15.27万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-11 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311727
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adult; COVID-19 pandemic; Child; Enrollment; Epidemiology; Funding; Health; Household; Human; Lung diseases; Monitor; National Institute of Allergy and Infectious Disease; Participant; Pediatric Research; Population; Serology; Surveys; Testing; United States National Institutes of Health; design; epidemiologic data; infection burden; infection rate; member; prospective; research study; response

The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available, especially in the context of households that are prospectively monitored with repetitive testing. This information is critical to determine the silent and symptomatic infection rate in children. The NIAID-supported Human Epidemiology and Response to SARS- CoV-2 (HEROS) survey study is designed to fill this gap.

2019冠状病毒病大流行是美国人口面临的最重要的健康挑战， 世纪。大多数流行病学数据都集中在导致严重呼吸道感染的病例上。 主要见于成人的疾病。关于感染负担的信息不足， 特别是在受到前瞻性监测的家庭中， 通过重复测试。这一信息对于确定沉默和症状是至关重要的 儿童感染率。NIAID支持的人类流行病学和对SARS的反应- CoV-2（HEROS）调查研究旨在填补这一空白。

项目成果

CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169.

• DOI: 10.1128/msphere.00505-21
• 发表时间: 2021-06-30
• 期刊: mSphere
• 影响因子: 4.8
• 作者: Fenutria R;Maringer K;Potla U;Bernal-Rubio D;Evans MJ;Harris E;Rahman AH;Fernandez-Sesma A;Ramos I
• 通讯作者: Ramos I

Ten Strategies of Interferon Evasion by Viruses.

病毒逃避干扰素的十种策略。

• DOI: 10.1016/j.chom.2017.07.012
• 发表时间: 2017-08-09
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: García-Sastre A

Innate Immune DNA Sensing of Flaviviruses.

• DOI: 10.3390/v12090979
• 发表时间: 2020-09-03
• 期刊: Viruses
• 作者: Zhu T;Fernandez-Sesma A
• 通讯作者: Fernandez-Sesma A

Generation and Characterization of Human-Mouse STING Chimeras That Allow DENV Replication in Mouse Cells.

• DOI: 10.1128/msphere.00914-21
• 发表时间: 2022-06-29
• 期刊: mSphere
• 影响因子: 4.8

TRIM25 in the Regulation of the Antiviral Innate Immunity.

• DOI: 10.3389/fimmu.2017.01187
• 发表时间: 2017
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Martín-Vicente M;Medrano LM;Resino S;García-Sastre A;Martínez I
• 通讯作者: Martínez I