EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG Queries

1.作为多PI（MPI）团队共同努力的理由。信息系统试点项目的核心是 两套资源和专业知识的结合， (PIs)，Sergio Baranzini博士（UCSF）和Sui Huang博士（ISB）将致力于开发，测试和 提供生物医学FOA定义的计算工具（“自动中继代理”，ARA） NCATS的翻译计划作为“第一阶段”的里程碑（2020年1月至3月）。的 这个团队设想的ARA是EVIDARA，一个从知识中提取知识的系统。 图（KG），并将其与大型队列的多组学原始数据进行评估，以获得证据支持。 然后，经过验证的知识将其传递给生物医学翻译。两 将被结合起来构建EVIDARA的资源是：（i）一个新的知识图，SPOKE和 (ii)一种新的多组学数据集，来自科学健康研究。这两个私家侦探 这两种资源，因此发挥互补作用：塞尔吉奥·巴兰齐尼博士，与他的团队在 UCSF是SPOKE的开发者，Sui Huang博士提供多组学方面的专业知识 研究并获得了他一直在分析的ISB研究队列的数据。 博士Baranzini将带来SPOKE及其新应用的所有计算方面的专业知识 黄博士还将担任多组学驱动的医疗实践的主题专家， 指导产品开发和测试的研究。 2.项目的目标和延续。试点项目的共同目标是 交付提案中所述的里程碑产品EVIDARA。如果试点项目是 成功，该团队被选中继续进行“第二部分”（最多五个项目） 这两个PI将再次作为MPI团队工作，并共同设计项目的扩展， 这是第二阶段，并共同为NCATS准备新的研究计划。 3.管理和协调。黄博士是MPI的联系人，将协调该项目 并直接与Baranzini博士沟通，以确保两个MPI随时了解 项目的技术进展和所有行政事项。每个MPI将假设财政和 行政管理自己的团队，反映在预算和财团 - 是的黄博士将负责与NCATS项目经理沟通 团队这两个MPI及其团队成员和机构合作者同意联合工作 作为一个团队朝着里程碑式的产品前进。如果出版物的结果，这两个将是共同的高级 作者及其团队成员根据其贡献被列为作者，如下 共同的学术实践。如果在项目过程中有任何冲突，PI和 合作者将亲自会面，本着合作精神解决任何冲突。给定 黄博士和Baranzini在学术上互动了近二十年，分享了 相同的学术观点以及他们的专业知识的互补性和协同性， 项目需要一个中立的仲裁委员会， 解决冲突。 4.知识产权。在知识产权方面， PI的机构将负责与研究和结果有关的协议 的工作。

1. Rationale for the joint effort as a multi-PI (MPI) team. At the core of the is pilot project is the combination of two sets of resources and expertise that each of the two principal investigators (PIs), Dr. Sergio Baranzini (UCSF) and Dr. Sui Huang (ISB) will contribute to develop, test and deliver a computational tool (“Automatic Relay Agent”, ARA) as defined by the FOA of Biomedical Translator program of NCATS as a milestone for the “First Segment” (January- March, 2020). The ARA envisioned by this team is EVIDARA, a system that extracts knowledge from a knowledge graph (KG) and evaluates it against multi-omics raw data of a large cohort for evidential support. The evidenced-tested knowledge is then relaying it to the Biomedical Translator. The two resources that will be combined to build EVIDARA are: (i) A novel knowledge graph, SPOKE and (ii) a new genre of multi-omics data sets from scientific wellness studies. The two PIs will bring these two resources and thus play complementary role: Dr. Sergio Baranzini, with his team at UCSF, is the developer of SPOKE and Dr. Sui Huang provides subject matter expertise in multiomics studies and has access to data from a cohort studied at ISB that he has been analyzing. Dr. Baranzini will bring expertise in all computational aspects of SPOKE and its new applications and Dr. Huang will also act as subject matter expert in multi-omics driven medical practice and research to guide product development and testing. 2. Goal of project and continuation. The pilot project id defined by the common goal of delivering the milestone product, EVIDARA as described in the proposal. If the pilot project is successful and this team is selected to continue to the “Second Segment” (an up to five project) the two PIs will work again as an MPI team and jointly design the expansion of the project into this second phase and jointly prepare the new research plan to NCATS. 3. Management and coordination. Dr. Huang, is the contact-MPI and will coordinate the project and directly communicate with Dr. Baranzini to ensure that both MPIs are kept informed about the project’s technical progress and all administrative matters. Each MPI will assume fiscal and administrative management of their own team, as reflected in the budget and consortium subcontract. Dr. Huang will be responsible for communication with NCATS Program manager team. The two MPIs and their team members and institutional collaborators agree to work jointly as a group towards the milestone product. Should publications result, both will be co-senior authors and their team members included as authors based on their contribution, following common academic practice. If there are any conflicts in the course of the project, both PIs and collaborators will meet in person and work in a spirit of cooperation to resolve any conflicts. Given that Drs. Huang and Baranzini have interacted academically for almost two decades, share the same scholarly perspective and the complementary and synergistic nature of their expertise that is required for the project it is highly unlikely a neutral arbitration committee would be required to resolve conflicts. 4. Intellectual Property. For intellectual property issue, the Technology Transfer Offices at each of the PI’s institutions will be responsible for agreements relating to the research and the outcome of the work.