Arbitration between habitual and goal-directed behavior in obsessive-compulsive disorder: circuit dynamics and effects of noninvasive neurostimulation

强迫症中习惯性行为和目标导向行为之间的仲裁：回路动力学和无创神经刺激的影响

• 批准号: 10841221
• 负责人: Reza Tadayon-Nejad
• 金额: $ 9.53万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10841221
• 关键词: Address; Adult; Arbitration; Area; Award; Behavior; Behavioral; Brain; Characteristics; Clinical; Decision Making; Development; Environment; Equilibrium; Functional Magnetic Resonance Imaging; Goals; Impairment; Individual; Knowledge; Left; Mental disorders; Mentors; Mentorship; Methodology; Motor; Neurosciences; Obsessive-Compulsive Disorder; Outcome; Parents; Participant; Performance; Persons; Prefrontal Cortex; Punishment; Records; Research Project Grants; Rewards; Scanning; Scientist; Solid; Symptoms; System; Task Performances; Training; behavior measurement; behavioral phenotyping; career; career development; clinical phenotype; clinically relevant; cognitive neuroscience; effective therapy; maladaptive behavior; neural; neurobehavioral; neuromechanism; novel; patient oriented; putamen; skills; transcranial direct current stimulation

Abstract (parent award): Dysfunctional decision-making may be a prominent mechanism underlying maladaptive behavior in multiple psychiatric disorders, including obsessive-compulsive disorder (OCD). Debilitating compulsivity and avoidance in OCD are believed to be a direct result of flawed decision-processing. A better understanding of the brain mechanisms of abnormal decision-making in OCD is essential for the development of more effective treatment options. This mentored patient-oriented career development project plans to address this underexplored area. By providing the necessary mentorship and support and building upon the candidate’s solid skillset in basic and clinical neuroscience, the primary goal of this K23 project is to establish the candidate’s career as an independent clinician-scientist with expertise in clinical decision neuroscience. The candidate will benefit from the clinical and academic environments of UCLA and Caltech as well as from a mentorship team with a complementary expertise and exceptional scientific and mentoring records to fill gaps in his knowledge and skills in 3 areas: 1) cognitive neuroscience of decision-making; 2) clinical neuroscience task-based functional magnetic resonance imaging (fMRI) methodology; and 3) noninvasive neurostimulation methodology. Integrated with the above-mentioned training goals, the research project will examine neurobehavioral characteristics of decision-making in OCD. [People utilize two behavioral strategies, goal-directed (GD) and habitual (HB) when engaging in value-based decision-making that involves rewarding or punishing outcomes. Furthermore, an arbitration mechanism has been proposed recently that controls the balance between those two strategies in healthy participants. Arbitration regions (the frontopolar and inferolateral prefrontal cortex (ilPFC)) regulate the goal-directed/habitual decision-making balance by selectively downregulating the activity of the habitual regions (putamen and supplementary motor area). In OCD, an imbalance exists between GD and HB action selection in favor of HB action selection. This project aims to explore the neurobehavioral characteristics of this arbitration mechanism and its relationship with behaviors and clinical phenotypes in OCD by applying cognitive neuroscience, clinical task-based fMRI and transcranial direct current stimulation (tDCS) approaches. Adults with OCD and healthy control participants will perform two tasks while being scanned, and when they receive inhibitory, excitatory, and sham tDCS over the left ilPFC outside of the scanner: I) a decision-making task in which GD and HB strategies compete to control action selection and II) a clinically relevant symptom provocation-avoidance task in which avoidance decisions will be simulated. The project’s research aims are to 1) explore the GD, HB, and arbitration regions’ neural activity and arbitration-habitual circuit connectivity in OCD; 2) examine the association between measures of behavioral performance, arbitration’s neural activity and connectivity, and OCD clinical symptoms; and 3) investigate the behavioral consequences of tDCS over an arbitration region, the left ilPFC, during task performance.]

摘要(家长奖)： 决策功能障碍可能是多发性精神分裂症患者不良适应行为的一个重要机制 精神障碍，包括强迫症(OCD)。令人衰弱的强迫症和回避 强迫症被认为是决策过程有缺陷的直接结果。更好地了解大脑 强迫症的异常决策机制对开发更有效的治疗方法至关重要 选择。这个指导以病人为导向的职业发展项目计划解决这一未被探索的领域。 通过提供必要的指导和支持，并在候选人扎实的基本技能基础上 和临床神经科学，这个K23项目的主要目标是建立候选人的职业生涯 独立临床医生-具有临床决策神经科学专业知识的科学家。候选人将从以下方面受益 加州大学洛杉矶分校和加州理工大学的临床和学术环境，以及来自 互补的专业知识和出色的科学和指导记录，以填补他在知识和 3个领域的技能：1)决策的认知神经科学；2)临床神经科学基于任务的功能 磁共振成像(FMRI)方法；3)非侵入性神经刺激方法。 结合上述培训目标，该研究项目将检查神经行为 强迫症患者的决策特点。[人们使用两种行为策略，目标导向(GD)和 在进行基于价值的决策时习惯性(HB)，这涉及到奖励或惩罚结果。 此外，最近还提出了一种仲裁机制，以控制这两项之间的平衡 健康参与者的两种策略。仲裁区域(额叶大脑皮层和下侧前额叶皮质 (IlPFC)通过有选择地下调活动来调节目标导向的/习惯性决策平衡 习惯性区域(壳核和辅助运动区)。在强迫症中，GD之间存在不平衡 以及有利于HB动作选择的HB动作选择。该项目旨在探索神经行为 这种仲裁机制的特点及其与强迫症行为和临床表型的关系 通过应用认知神经科学、临床任务型功能磁共振成像和经颅直流电刺激(Tdcs) 接近了。患有强迫症的成年人和健康对照组参与者在接受扫描时将执行两项任务，以及 当他们在扫描仪外部的左侧ilPFC上收到抑制性、兴奋性和假tDCs时：i)a 决策任务，其中GD和HB策略竞争以控制行动选择和ii)临床 相关症状激发-回避任务，其中将模拟回避决策。该项目的 研究目的：1)探讨广东、河北和仲裁地区的神经活动和仲裁习惯 强迫症中的电路连通性；2)检查行为表现的测量之间的关联， 仲裁的神经活动和连接性，以及强迫症的临床症状；3)调查行为 在任务执行期间，tdcs对仲裁区域(左侧ilPFC)的影响。]

项目成果

Right lateral orbitofrontal cortex inhibitory transcranial magnetic stimulation for treatment of refractory mood and depression.

右侧眶额皮质抑制性经颅磁刺激治疗难治性情绪和抑郁症。

• DOI: 10.1016/j.brs.2023.09.011
• 发表时间: 2023
• 期刊: Brain stimulation
• 影响因子: 7.7
• 作者: Tadayonnejad,Reza;Citrenbaum,Cole;Ngo,ThucDoanP;Corlier,Juliana;Wilke,ScottA;Slan,Aaron;Distler,MargaretG;Hoftman,Gil;Adelekun,AdesewaE;Leuchter,MichaelK;Koek,RalphJ;Ginder,NathanielD;Krantz,David;Artin,Hewa;Strouse,Th
• 通讯作者: Strouse,Th

White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa.

习惯决策回路中的白质特征是神经性厌食症的仪式行为。

• DOI: 10.1038/s41598-021-95300-3
• 发表时间: 2021-08-05
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Tadayonnejad R;Pizzagalli F;Murray SB;Pauli WM;Conde G;Bari AA;Strober M;O'Doherty JP;Feusner JD
• 通讯作者: Feusner JD

Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder.

使用右眶额重复经颅磁刺激（rTMS）增强治疗合并重度抑郁症的难治性强迫症。

• DOI: 10.1016/j.psychres.2022.114856
• 发表时间: 2022
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Tadayonnejad,Reza;Wilson,AndrewC;Chu,StephanieAnne;Corlier,Juliana;Citrenbaum,Cole;Ngo,ThucDoanP;Hovhannisyan,Emmily;Ginder,NathanielD;Levitt,JenniferG;Wilke,ScottA;Krantz,David;Bari,AusafA;Leuchter,AndrewF
• 通讯作者: Leuchter,AndrewF

Rumination symptoms in treatment-resistant major depressive disorder, and outcomes of repetitive Transcranial Magnetic Stimulation (rTMS) treatment.

• DOI: 10.1038/s41398-023-02566-4
• 发表时间: 2023-09-08
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Chu, Stephanie A.;Tadayonnejad, Reza;Corlier, Juliana;Wilson, Andrew C.;Citrenbaum, Cole;Leuchter, Andrew F.
• 通讯作者: Leuchter, Andrew F.

Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders.

• DOI: 10.1016/j.nicl.2022.103073
• 发表时间: 2022
• 期刊: NEUROIMAGE-CLINICAL
• 影响因子: 4.2
• 作者: Seok, Darsol;Tadayonnejad, Reza;Wong, Wan-wa;O'Neill, Joseph;Cockburn, Jeff;Bari, Ausaf A.;O'Doherty, John P.;Feusner, Jamie D.
• 通讯作者: Feusner, Jamie D.