Advancing Research on Mechanisms of Resilience (ARMOR): Prospective Longitudinal

推进弹性机制（ARMOR）的研究：前瞻性纵向

• 批准号: 10338676
• 负责人: Christopher R Erbes
• 金额: $ 24.85万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10338676
• 关键词: Adverse event; Alcohol consumption; Anxiety; Area; Attention; Behavior; Behavioral; Biological; Cognition; Cognitive; Collaborations; Data Collection; Data Set; Drug usage; Electroencephalography; Emotions; Enrollment; Environment; Evaluation; Exposure to; Goals; Growth; Healthcare Systems; Image; Individual Differences; Informal Social Control; Integrative Medicine; Laboratories; Life; Longevity; Longitudinal Studies; Longitudinal cohort study; Magnetic Resonance Imaging; Measurement; Measures; Mental Depression; Mental Health; Methods; Military Personnel; Mind-Body Intervention; Minnesota; Modeling; Monitor; Neurobiology; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Personality Traits; Phase; Pilot Projects; Populations at Risk; Prevention; Probability; Procedures; Process; Psyche structure; Psychopathology; Psychophysiology; Regulation; Research; Research Personnel; Risk; Risk Factors; Scanning; Services; Social Functioning; Soldier; Spouses; Statistical Algorithm; Statistical Models; Stress; Substance abuse problem; Surveys; Symptoms; Task Performances; Time; Training; Universities; Work; acceptability and feasibility; base; cognitive neuroscience; cohort; combat training; conduct problem; contextual factors; cost; developmental psychology; farmer; field study; first responder; flexibility; high risk; infancy; military service; neurobehavioral; novel; physical conditioning; prediction algorithm; predictive modeling; preventive intervention; prospective; protective factors; recruit; resilience; response; service member; sexual risk taking; social; stressor

Background: Resilience is defined as the capacity to adapt successfully through multiple processes in response to adverse events. While explanatory models are still in their infancy, theoretical and empirical evidence suggest that self-regulatory processes may underlie resilient functioning. This proposal will develop (Phase 1, Year 1) and then implement (Phase 2, Years 2-5) a study of 1,200 National Guard recruits in the first two years of their enlistment in order to identify patterns and processes of adaptive (resilient) functioning in the face of Basic Combat Training (BCT) and other adverse events. Aims: The aims for Phase 1 are focused on planning and preparing for a longitudinal study of resilience in National Guard recruits and include: 1) Use prior datasets to develop statistical algorithms for selecting ilot baseline data collection procedures to determine feasibility of enrollment and response rate targets for longitudinal study, 3) Develop and refine contextualized measures of National Guard training stressor exposure, and 4) Evaluate the feasibility and acceptability of neurobehavioral markers of resilience processes. During Phase 2, a comprehensive model of resilience will be investigated using a four-year, mixed-method, longitudinal study to participants with high and low probabilities of resilience, 2) P 1) Characterize latent trajectories of adjustment among new military recruits beginning prior to BCT over two years, 2) Identify promotive and protective predictors of resilient functioning in National Guard soldiers, and 3) Investigate neurobehavioral pathways of self-regulation predictive of resilience trajectories in new military recruits. Procedures and Analyses: In Phase 1, prediction algorithms will be established using analysis of datasets gathered in prior National Guard studies. The measurement of BCT stressors, and feasibility of Phase 2 recruitment plans, will involve online surveys of 100 National Guard recruits before, during and immediately after BCT. The feasibility and acceptability of neurobiological measures through imaging and laboratory tasks piloting procedures will be assessed with 10 recruits undergoing procedures before and after BCT. In Phase 2, on-line self-reports of symptoms (depression, anxiety, alcohol or drug use), adaptive social functioning, and promotive, protective, and risk factors will be collected before and at 4 time points after BCT with 1200 National Guard recruits. Growth mixture modeling will establish resilient and non-resilient trajectories of adaptive functioning. Aim 2 will use predictive modeling of trajectories using predictors collected during the baseline and subsequent time points. In Aim 3, 120 recruits will complete laboratory tasks (Farmer's task, go/no-go task, dot probe task, performance monitoring task) before and after BCT while undergoing MRI or EEG scans. Analyses will determine if these tasks can discriminate between recruits in the resilient vs. non- resilient trajectories of functioning established in Aim 1.

背景：复原力被定义为通过多个过程成功适应的能力 对不良事件的反应。虽然解释模型仍处于初级阶段，但无论是理论模型还是经验模型 有证据表明，自我监管过程可能是弹性运作的基础。这项提议将得到发展。 (第一阶段，第一年)，然后实施(第二阶段，第二至第五年)对第一阶段1200名国民警卫队新兵的研究 他们应征入伍两年，以确定适应性(恢复力)在 面对基本战斗训练(BCT)和其他不良事件。 目标：第一阶段的目标是规划和准备在 国民警卫队招募人员包括： 1)使用先前的数据集来开发统计算法以进行选择 ILOT基线数据收集程序 确定纵向研究的招生和应答率目标的可行性，3)开发和完善 国民警卫队训练应激源暴露的情境化措施，以及4)评估可行性和 恢复力过程的神经行为标记物的可接受性。在第二阶段，一个全面的 将使用一项为期四年的混合方法纵向研究来调查弹性 具有高和低弹性概率的参与者，2)P 1)描述潜伏期 BCT前两年开始的新兵调整轨迹，2)确定 国民警卫队士兵弹性功能的促进和保护性预测因素，以及3)调查 自我调节的神经行为通路预测新兵的复原力轨迹。 程序和分析：在第一阶段，将使用数据集分析建立预测算法 在之前的国民警卫队研究中收集的。BCT应激源的测量和第二阶段的可行性 招募计划将包括在招募之前、期间和立即对100名国民警卫队新兵进行在线调查 在BCT之后。通过成像和实验室任务进行神经生物学测量的可行性和可接受性 将对10名新兵在BCT前后进行的飞行程序进行评估。 在第二阶段，在线自我报告症状(抑郁、焦虑、酗酒或吸毒)、适应性社交 在BCT之前和之后的4个时间点收集功能性、促进性、保护性和风险因素 有1200名国民警卫队新兵。混合增长模型将建立弹性和非弹性轨迹 自适应功能。AIM 2将使用在 基线和后续时间点。在AIM 3中，120名新兵将完成实验室任务(Farmer任务， Go/no-go任务、Dot Probe任务、性能监测任务) 脑电波扫描。分析将确定这些任务是否可以区分有弹性和无弹性的新兵 目标1确立了有弹性的运作轨迹。