Molecular Mechanisms of Social Behavior

社会行为的分子机制

基本信息

批准号：
10330887
负责人：
ANNA KUKEKOVA
金额：
$ 38.51万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2027-07-31
项目状态：
未结题

项目摘要

Multiple human psychiatric disorders are associated with unusual social behaviors related to aggression, anxiety, and affiliation. Although the genetic component of these disorders is well established, their inheritance is complex and identification of the causative genes is often extremely difficult. The growth of phenotypic and genetic information, however, revealed that unusual behaviors observed in these disorders often represent the extreme ends of behavioral variation observed in the general population, suggesting that genes implicated in social behavior in unaffected population also influence disorder risk and symptom severity. To identify the genes and pathways disturbed in psychiatric disorders, an understanding of the molecular basis of mammalian social behavior would provide a crucial step forward. The goals of this project are to resolve differences in affiliation, aggression, and anxiety- like behaviors segregating in the red fox (Vulpes vulpes) with the intent of providing valuable insights into the mechanisms underlying a broad range of mammalian social behaviors, including human psychiatric disorders. The specific fox strains developed at the Institute of Cytology and Genetics (ICG) of the Russian Academy of Sciences exhibit markedly different, genetically determined behavioral phenotypes with significant parallels to typical and atypical human behaviors. The fox strains are well prepared for genetic, molecular, and cellular studies of social behavior and represent a unique, novel, and significant large animal model. The identification of molecular mechanisms influencing social behavior in foxes is expected to provide new insights into human disorders of social behavior and facilitate integration of human and rodent studies, thereby leading to the development of potential therapies.

多种人类精神疾病与与众不同的社会行为有关侵略，焦虑和隶属关系。尽管这些疾病的遗传成分很好建立，它们的遗传是复杂的，对病因基因的识别通常是极其困难。然而，表型和遗传信息的生长表明在这些疾病中观察到的异常行为通常代表行为的极端在普通人群中观察到的差异，表明与社会行为有关的基因在不受影响的人群中，还会影响疾病的风险和症状严重程度。识别基因和途径受到精神疾病的干扰，对分子基础的理解哺乳动物的社会行为将提供至关重要的一步。该项目的目标是解决隶属关系，侵略和焦虑的差异 - 就像在红狐（vulpes vulpes）中隔离的行为一样，目的是提供宝贵的行为洞悉广泛的哺乳动物社会行为的机制，包括人类精神疾病。特定的狐狸菌株在细胞学研究所和俄罗斯科学学院的遗传学（ICG）表现出明显不同的遗传学确定的行为表型与典型和非典型人的显着相似之处行为。 FOX菌株已经为社会的遗传，分子和细胞研究做好了充分的准备行为并代表独特，新颖且重要的大型动物模型。识别影响狐狸社会行为的分子机制有望提供新的见解进入社会行为的人类疾病，并促进人类和啮齿动物研究的整合，从而导致潜在疗法的发展。