Molecular Mechanisms of Social Behavior

社会行为的分子机制

• 批准号: 10330887
• 负责人: ANNA KUKEKOVA
• 金额: $ 38.51万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10330887
• 关键词: Academy; Aggressive behavior; Animal Model; Anxiety; Behavior; Behavioral; Canis familiaris; Complex; Cytology; Development; Disease; Exhibits; Foxes; General Population; Genes; Genetic; Genetic study; Goals; Growth; Human; Impairment; Inherited; Institutes; Mental disorders; Molecular; Pathway interactions; Persons; Phenotype; Population; Rodent; Science; Severities; Social Behavior; Social Behavior Disorders; Social Facilitation; Symptoms; Variant; Vulpes; Wolves; anxiety-like behavior; behavioral phenotyping; disorder risk; genetic information; insight; nervous system disorder; novel; social influence; social reciprocity

Multiple human psychiatric disorders are associated with unusual social behaviors related to aggression, anxiety, and affiliation. Although the genetic component of these disorders is well established, their inheritance is complex and identification of the causative genes is often extremely difficult. The growth of phenotypic and genetic information, however, revealed that unusual behaviors observed in these disorders often represent the extreme ends of behavioral variation observed in the general population, suggesting that genes implicated in social behavior in unaffected population also influence disorder risk and symptom severity. To identify the genes and pathways disturbed in psychiatric disorders, an understanding of the molecular basis of mammalian social behavior would provide a crucial step forward. The goals of this project are to resolve differences in affiliation, aggression, and anxiety- like behaviors segregating in the red fox (Vulpes vulpes) with the intent of providing valuable insights into the mechanisms underlying a broad range of mammalian social behaviors, including human psychiatric disorders. The specific fox strains developed at the Institute of Cytology and Genetics (ICG) of the Russian Academy of Sciences exhibit markedly different, genetically determined behavioral phenotypes with significant parallels to typical and atypical human behaviors. The fox strains are well prepared for genetic, molecular, and cellular studies of social behavior and represent a unique, novel, and significant large animal model. The identification of molecular mechanisms influencing social behavior in foxes is expected to provide new insights into human disorders of social behavior and facilitate integration of human and rodent studies, thereby leading to the development of potential therapies.

多种人类精神疾病与不寻常的社会行为有关 攻击性焦虑和归属感虽然这些疾病的遗传成分是很好的 它们的遗传是复杂的，致病基因的鉴定通常是 非常困难。然而，表型和遗传信息的增长表明， 在这些疾病中观察到的异常行为通常代表了行为的极端， 在一般人群中观察到的变异，表明与社会行为有关的基因 在未受影响人群中也影响疾病风险和症状严重程度。为了识别基因 以及精神疾病中的干扰途径，对精神疾病分子基础的理解， 哺乳动物的社会行为将提供关键的一步。 这个项目的目标是解决归属，侵略和焦虑的差异- 就像赤狐（Vulpes vulpes）的行为分离一样， 深入了解各种哺乳动物社会行为的机制，包括 人类精神疾病细胞学研究所开发的特定狐狸品系， 俄罗斯科学院的遗传学（ICG）表现出显着不同的，遗传 确定的行为表型与典型和非典型人类显著相似 行为。狐狸品系为社会性的遗传、分子和细胞研究做好了充分的准备。 行为，并代表了一个独特的，新颖的，重要的大型动物模型。的识别 影响狐狸社会行为的分子机制有望提供新的见解 研究人类社会行为障碍，并促进人类和啮齿动物研究的整合， 从而导致潜在疗法的发展。