Molecular Mechanisms of Social Behavior

社会行为的分子机制

• 批准号: 7905174
• 负责人: ANNA KUKEKOVA
• 金额: $ 32.58万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905174
• 关键词: Academy; Animal Model; Anxiety; Autistic Disorder; Backcrossings; Behavior; Behavior Control; Behavior Disorders; Behavioral; Biological; Breeding; Candidate Disease Gene; Canis familiaris; Chromosome Mapping; Collaborations; Cytology; Data; Development; Disease; Etiology; Exhibits; Founder Generation; Foxes; Functional disorder; Generations; Genes; Genetic; Genome; Genomics; Goals; Haplotypes; Human; Infant; Inherited; Institutes; Joints; Laboratories; Linkage Disequilibrium; Linkage Disequilibrium Mapping; Mammals; Maps; Measurable; Measures; Meiosis; Mental Depression; Methods; Modeling; Molecular; Molecular Genetics; Nature; Panic Disorder; Pattern; Personality Disorders; Phenotype; Pilot Projects; Positioning Attribute; Primates; Principal Component Analysis; Quantitative Trait Loci; Research; Research Personnel; Research Project Grants; Resources; Rodent; Schizophrenia; Science; Scientist; Silver; Social Behavior; Social Behavior Disorders; Social Interaction; Staging; Testing; Universities; Utah; Vulpes; genetic pedigree; insight; novel; professor; programs; tool; trait

DESCRIPTION (provided by applicant): The goal of this project to fully understand the genetics of certain inherited behaviors segregating in specific strains of silver foxes. The range of behaviors in these foxes has significant parallels to that of normal and disordered patterns of human sociability. The proposed research will characterize the genetic loci determining fox behavioral phenotypes to yield insights into the genetics of social behavior and its underlying molecular mechanisms, not only in foxes, but in other mammals, including humans. In previous studies, specific strains of silver fox (Vulpes vulpes) were developed, at the Russian Institute of Cytology and Genetics (ICG), that exhibit extremely friendly behavior towards humans, in contrast to their wild-type ancestors that resist human contact. The current proposal is a joint research project between scientists at Cornell University, ICG, and the University of Utah, to define the molecular genetic mechanisms underlying these different behaviors. Fox behavioral phenotypes have been defined using principal-components analysis. Genetic loci underlying these behavioral phenotypes have been mapped in powerful sets of fox backcross pedigrees using the newly developed meiotic linkage map of the fox genome. These identified quantitative trait loci will be validated in extended sets of highly informative experimental pedigrees. Combined linkage and linkage disequilibrium mapping will be applied to define the critical regions of the fox genome in which quantitative trait loci have been identified, and identify potential candidate genes. The effect of identified loci on behavior will be determined in experimental pedigrees using marker assisted selection. The identification of genes and loci influencing social behavior in foxes is anticipated to provide new insights into, and candidate genes for human disorders of social behavior. Furthermore, such a well- established large animal model, intermediate between rodents and primates in biological complexity, would then offer opportunities to investigate potential therapies for such human disorders as autism, schizophrenia, anxiety, depression, personality disorders, panic disorder and other traits.

描述（由申请人提供）：该项目的目标是充分了解特定银狐品系中分离的某些遗传行为的遗传学。这些狐狸的行为范围与人类正常和无序的社交模式非常相似。拟议的研究将描述决定狐狸行为表型的遗传位点，以深入了解社会行为的遗传学及其潜在的分子机制，不仅在狐狸中，而且在包括人类在内的其他哺乳动物中。在之前的研究中，俄罗斯细胞学和遗传学研究所（ICG）培育出了特定的银狐（Vulpes vulpes）品系，它们对人类表现出极其友好的行为，这与它们抵抗人类接触的野生型祖先形成鲜明对比。目前的提案是康奈尔大学、ICG 和犹他大学科学家之间的联合研究项目，旨在定义这些不同行为背后的分子遗传机制。狐狸的行为表型已使用主成分分析来定义。使用新开发的狐狸基因组减数分裂连锁图谱，这些行为表型背后的遗传位点已被绘制在强大的狐狸回交谱系中。这些确定的数量性状基因座将在大量信息丰富的实验谱系中得到验证。将应用组合连锁和连锁不平衡作图来定义狐狸基因组中已鉴定出数量性状基因座的关键区域，并鉴定潜在的候选基因。将使用标记辅助选择在实验谱系中确定已识别基因座对行为的影响。影响狐狸社会行为的基因和基因座的鉴定预计将为人类社会行为障碍提供新的见解和候选基因。此外，这种成熟的大型动物模型，其生物复杂性介于啮齿类动物和灵长类动物之间，将为研究人类疾病（如自闭症、精神分裂症、焦虑症、抑郁症、人格障碍、恐慌症和其他特征）的潜在疗法提供机会。

项目成果

Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes).

• DOI: 10.1371/journal.pone.0127013
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Johnson JL;Wittgenstein H;Mitchell SE;Hyma KE;Temnykh SV;Kharlamova AV;Gulevich RG;Vladimirova AV;Fong HW;Acland GM;Trut LN;Kukekova AV
• 通讯作者: Kukekova AV

Explosive vocal activity for attracting human attention is related to domestication in silver fox.

• DOI: 10.1016/j.beproc.2010.12.001
• 发表时间: 2011-02
• 期刊: BEHAVIOURAL PROCESSES
• 影响因子: 1.3
• 作者: Gogoleva, Svetlana S.;Volodin, Ilya A.;Volodina, Elena V.;Kharlamova, Anastasia V.;Trut, Lyudmila N.
• 通讯作者: Trut, Lyudmila N.

Georgian white coat color of red fox (Vulpes vulpes) maps to fox chromosome 2 in the region containing KIT gene.

红狐（Vulpes vulpes）的格鲁吉亚白毛色映射到狐狸2号染色体上含有KIT基因的区域。

• DOI: 10.1111/age.12439
• 发表时间: 2016
• 期刊: Animal genetics
• 影响因子: 2.4
• 作者: Kukekova,AnnaV;Johnson,JenniferL;Kharlamova,AnastasiyaV;Vladimirova,AnastasiyaV;Shepeleva,DaryaV;Gulevich,RimmaG;Trut,LyudmilaN
• 通讯作者: Trut,LyudmilaN