Molecular Mechanisms of Social Behavior

社会行为的分子机制

基本信息

批准号：
9356552
负责人：
ANNA KUKEKOVA
金额：
$ 29.57万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-26 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9356552
关键词：
Academy Affect Aggressive behavior Agriculture Animal Model Anxiety Anxiety Disorders Architecture Autistic Disorder Behavior Behavior Therapy Behavioral Behavioral Genetics Biological Biological Models Bipolar Disorder Brain Breeding Candidate Disease Gene Canis familiaris Complex Cytology Development Disease Environmental Risk Factor Evaluation Exhibits Fishes Foxes Gene Expression Generations Genes Genetic Genetic Polymorphism Genetic Predisposition to Disease Genetic study Genome Genomics Goals Heritability Heterogeneity Human Human Genetics Illinois Impairment Individual Inherited Insecta Institutes Intention Intermittent Explosive Disorders Joints Knowledge Location Maps Meiosis Mental disorders Modeling Molecular Mus Pathway interactions Patients Pharmacology Phenotype Population Preparation Primates Quantitative Trait Loci Regulation Regulator Genes Research Project Grants Resolution Resources Rodent Schizophrenia Science Scientist Signal Transduction Silver Social Behavior Social Behavior Disorders Social Interaction Study models System Testing Universities Vulpes Williams Syndrome Wolves Work affiliative behavior behavioral impairment behavioral study expectation genetic analysis genetic pedigree genomic tools insight nervous system disorder novel offspring social social communication social reciprocity tool trait transcriptome sequencing

项目摘要

PROJECT SUMMARY Multiple human neurological disorders are associated with deficits in social interaction and communication. Although a genetic component of these disorders is well established, their inheritance is complex, and the identification of functional connections between disease loci and impaired behaviors has proven to be extremely difficult. Integration of human genetic studies with studies of animal models will facilitate advances in establishing the comprehensive molecular networks that regulate social behaviors and the identification of gene pathways disrupted in mental disorders. The goals of this project are to dissect specific heritable behaviors segregating in the silver fox (Vulpes vulpes) into discrete interacting components that are understood at the molecular level with the intent of providing valuable insights into the mechanisms underlying a broad range of mammalian interactive social behaviors, including human psychiatric disorders. The specific fox strains developed at the Institute of Cytology and Genetics (ICG) of the Russian Academy of Sciences exhibit markedly different, genetically determined behavioral phenotypes with significant parallels to typical and atypical human behaviors. The current proposal is a joint research project between scientists at the University of Illinois at Urbana-Champaign, the ICG, and the Swedish University of Agricultural Sciences to define the molecular mechanisms underlying these behavioral phenotypes. To investigate the genetics of these behaviors we will 1) identify and compare the genetic architecture of aggressive, anxiety-related, and affiliative behaviors in foxes and 2) fine map fox behavioral loci and define candidate genes and molecular pathways involved in the regulation of these behaviors. The identification of loci and genes influencing social behavior in foxes is expected to provide new insights into, and candidate genes for, human disorders of social behavior. Furthermore, such a well-established large animal model, intermediate to rodents and primates in biological complexity, can serve as a bridge between humans and rodents for molecular studies of behavior, thereby leading to the development of potential therapies.

项目摘要多种人类神经系统疾病与社会互动中的缺陷有关沟通。尽管这些疾病的遗传成分已经建立得很好，但它们的继承是复杂，以及疾病基因座与行为受损之间的功能连接的识别具有被证明非常困难。人类遗传研究与动物模型研究的整合将促进建立规范社会行为和的综合分子网络的进步精神障碍中破坏基因途径的识别。该项目的目标是剖析银狐（vulpes vulpes）分散的相互作用组件，这些组件在分子水平上被理解为提供对广泛哺乳动物互动社会的机制的宝贵见解行为，包括人类精神疾病。细胞学研究所开发的特定狐狸菌株俄罗斯科学院的遗传学（ICG）表现出明显不同的遗传确定行为表型与典型和非典型人类行为具有显着相似之处。当前的建议是伊利诺伊大学Urbana-Champaign，ICG和ICG的科学家之间的联合研究项目瑞典农业科学定义了这些分子机制行为表型。为了研究这些行为的遗传学，我们将1）识别和比较遗传结构狐狸的侵略性，与焦虑相关的和隶属行为的行为和2）精细地图狐狸行为基因座并定义候选基因和分子途径涉及这些行为的调节。识别影响狐狸社会行为的基因座和基因预计将提供新的见解，候选人基因，社会行为的人类疾病。此外，这是如此良好的大型动物模型在生物复杂性的啮齿动物和灵长类用于行为分子研究的啮齿动物，从而导致潜在疗法的发展。