Harvard Chemical Biology PhD Program

项目摘要 此申请请求支持哈佛大学化学生物学博士项目。这 深刻的跨学科课程培养了非常有才华的学生，以开展独立的研究， 化学生物学的前沿，利用概念和实验解决生物和医学问题 从化学和生物学的许多领域中提取的方法，并开发新的，广泛相关的 技术.该培训计划提供了化学生物学的一系列非凡的培训机会。 哈佛剑桥校区的教职员工提供世界一流的专业知识， 有机化学和分子生命科学，而在哈佛医学院（HMS）的教员 在分子生命科学和生物医学问题之间的接口提供突出的优势。在 此外，哈佛和麻省理工学院的布罗德研究所是基因组学相关技术开发的领导者， 治疗发现和医学。因此，该方案是一种转移概念的机制， 从化学到生物学、医学和基因组学，反之亦然。 学生从各种背景进入该计划。第一年必修课程，提供核心 在动力学，化学结构和反应性以及热力学概念的应用培训， 生物学的背景。学生还必须参加课程的重点是可重复的研究，统计， 以及团队合作、沟通和道德。第一年课程的统一主题 和讨论的是化学工具和方法在解剖生物途径中的作用。 学生还选修合成有机化学，微生物学，细胞生物学，结构 生物学、遗传学和基因组学、蛋白质组学、代谢组学和系统生物学。他们暴露在一个 通过课程，与教师的互动，在化学生物学的技术和概念的不寻常的范围 和其他学生，以及计划活动，如计划撤退和学生数据俱乐部。此外他们 发展沟通技巧，获得教学经验，并接受负责任行为的培训 research.学员还支持探索学术界内外的广泛职业。的 之前的赠款支持了10名学员，我们在这个新提案中请求支持10名学员。 该计划旨在吸引有才华的学生的多元化社区，并为他们提供密集，个性化 支持他们发展对生物学问题和化学概念的跨学科理解， 方法，并获得独立提出和回答这些问题。该计划特别支付 注意严谨性和再现性，培训学生的物理化学基础的测量， 使和在适当的技术，和常见的陷阱，在科学分析。通信培训 跨学科和非专业公众是该计划的基础，并在每个 学生的职业生涯。沟通也是未来多种职业的基础。

Project Summary This application requests support for the PhD Program in Chemical Biology at Harvard University. This profoundly interdisciplinary program trains highly talented students to carry out independent research at the forefront of chemical biology, addressing biological and medical problems using concepts and experimental approaches drawn from many areas of chemistry and biology and developing novel, broadly relevant technologies. The training program offers an extraordinary range of training opportunities in chemical biology. Faculty members at Harvard’s Cambridge campus offer world-class expertise in the disciplines spanning organic chemistry and the molecular life sciences, while faculty members at the Harvard Medical School (HMS) offer outstanding strengths at the interface between the molecular life sciences and biomedical problems. In addition, the Broad Institute of Harvard and MIT is a leader in technology development relevant to genomics, therapeutic discovery and medicine. The Program thus represents a mechanism to transfer concepts and technologies from chemistry to biology, medicine and genomics and vice versa. Students enter the program from a variety of backgrounds. Required coursework in the first year, provides core training in kinetics, chemical structure and reactivity as well as the application of thermodynamic concepts in the context of biology. Students are also required to take courses focused on reproducible research, statistics, and record-keeping as well as teamwork, communication and ethics. A unifying theme of first year coursework and discussions is the role of chemical tools and approaches in dissecting biological pathways. Students also take elective courses in synthetic organic chemistry, microbiology, cell biology, structural biology, genetics and genomics, proteomics, metabolomics and systems biology. They are exposed to an unusual range of technologies and concepts in chemical biology through coursework, interactions with faculty and other students, and Program events such as the Program retreat and Student Data Club. In addition, they develop communication skills, gain teaching experience and receive training in responsible conduct of research. Trainees are also supported in exploring a wide range of careers inside and outside academia. The previous grant supported 10 trainees and we request support for 10 trainees in this new proposal. The Program aims to attract a diverse community of talented students and give them intensive, personalized support as they develop an interdisciplinary understanding of biological questions and chemical concepts and approaches, and gain independence in posing and answering such questions. The program pays particular attention to rigor and reproducibility, training students in the physicochemical basis of the measurements they make and in appropriate techniques, and common pitfalls, in scientific analysis. Training for communication across disciplines and to the lay public is foundational for the Program and is emphasized throughout each student’s career. Communication is also foundational for multiple types of future careers.