Harvard Chemical Biology PhD Program

项目摘要 本申请申请支持哈佛大学化学生物学博士项目。这 深刻的跨学科计划培养有才华的学生在大学进行独立研究 化学生物学前沿，使用概念和实验解决生物和医学问题 从化学和生物学的许多领域吸取的方法，并开发新的、广泛相关的 技术。该培训计划提供了一系列非凡的化学生物学培训机会。 哈佛大学剑桥校区的教职员工在各个学科中提供世界级的专业知识 有机化学和分子生命科学，而哈佛医学院(HMS)的教员 在分子生命科学和生物医学问题之间提供卓越的优势。在……里面 此外，哈佛大学和麻省理工学院的博德研究所是与基因组学相关的技术开发的领导者， 治疗发现和医学。因此，该方案代表了一种机制，以转移概念和 从化学到生物、医学和基因组学的技术，反之亦然。 来自不同背景的学生进入该项目。第一年的必修课程，提供核心课程 关于动力学、化学结构和反应性的培训以及热力学概念的应用 生物学的背景。学生还被要求选修专注于可重复性研究、统计学、 以及记录保存以及团队合作、沟通和道德规范。一年级课程作业的统一主题 而讨论的是化学工具和方法在解剖生物途径中的作用。 学生还选修合成有机化学、微生物学、细胞生物学、结构 生物学、遗传学和基因组学、蛋白质组学、代谢组学和系统生物学。他们暴露在一种 通过课程学习、与教员的互动，在化学生物学领域拥有一系列不同寻常的技术和概念 和其他学生，以及计划活动，如计划休养和学生数据俱乐部。此外，他们还 培养沟通技巧，获得教学经验，并接受负责任的行为培训 研究。学员在学术界内外探索广泛的职业领域也得到支持。这个 以前的拨款资助了10名学员，我们请求在这项新提案中支持10名学员。 该计划旨在吸引一个多样化的有才华的学生社区，并为他们提供密集的、个性化的 支持他们发展对生物学问题和化学概念的跨学科理解，并 方法，并在提出和回答这些问题时获得独立性。该计划支付的特别费用 注意严谨和重复性，培训学生在测量的物理化学基础上他们 在科学分析中使用适当的技术和常见的陷阱。沟通训练 跨学科和面向非专业公众是该计划的基础，并贯穿于每个 学生生涯。沟通也是未来多种职业的基础。

Project Summary This application requests support for the PhD Program in Chemical Biology at Harvard University. This profoundly interdisciplinary program trains highly talented students to carry out independent research at the forefront of chemical biology, addressing biological and medical problems using concepts and experimental approaches drawn from many areas of chemistry and biology and developing novel, broadly relevant technologies. The training program offers an extraordinary range of training opportunities in chemical biology. Faculty members at Harvard’s Cambridge campus offer world-class expertise in the disciplines spanning organic chemistry and the molecular life sciences, while faculty members at the Harvard Medical School (HMS) offer outstanding strengths at the interface between the molecular life sciences and biomedical problems. In addition, the Broad Institute of Harvard and MIT is a leader in technology development relevant to genomics, therapeutic discovery and medicine. The Program thus represents a mechanism to transfer concepts and technologies from chemistry to biology, medicine and genomics and vice versa. Students enter the program from a variety of backgrounds. Required coursework in the first year, provides core training in kinetics, chemical structure and reactivity as well as the application of thermodynamic concepts in the context of biology. Students are also required to take courses focused on reproducible research, statistics, and record-keeping as well as teamwork, communication and ethics. A unifying theme of first year coursework and discussions is the role of chemical tools and approaches in dissecting biological pathways. Students also take elective courses in synthetic organic chemistry, microbiology, cell biology, structural biology, genetics and genomics, proteomics, metabolomics and systems biology. They are exposed to an unusual range of technologies and concepts in chemical biology through coursework, interactions with faculty and other students, and Program events such as the Program retreat and Student Data Club. In addition, they develop communication skills, gain teaching experience and receive training in responsible conduct of research. Trainees are also supported in exploring a wide range of careers inside and outside academia. The previous grant supported 10 trainees and we request support for 10 trainees in this new proposal. The Program aims to attract a diverse community of talented students and give them intensive, personalized support as they develop an interdisciplinary understanding of biological questions and chemical concepts and approaches, and gain independence in posing and answering such questions. The program pays particular attention to rigor and reproducibility, training students in the physicochemical basis of the measurements they make and in appropriate techniques, and common pitfalls, in scientific analysis. Training for communication across disciplines and to the lay public is foundational for the Program and is emphasized throughout each student’s career. Communication is also foundational for multiple types of future careers.