Administrative Core

项目概要/摘要-行政核心 我们建议建立一个生物医学研究卓越中心（COBRE）在药物研究 在肯塔基州大学（英国）的创新。CPRI将作为一个综合性的多学科中心 专注于转化化学生物学[化学生物学的联系（化学生物学的应用 开发经验证的探针/模型的原则，以促进我们对生物学和药物的理解 科学（应用药学原理来推进电极导线/材料/器械， 临床需要）。COBRE将利用和开发独特的转化化学生物学研究支持 基础设施/专业知识，以促进初级教师辅导和职业发展，创新的生物医学 研究探针/工具/模型/材料的开发和验证，以及潜在的早期进展 “可翻译”资产在此背景下，CPRI行政核心将支持中心通信， 协调、监督和整合所有COBRE行动、活动、项目、试点和研究支持 丹核心小组将提供财政管理和资源监督，全面协调指导， 职业发展活动、资源分配和计划评估，以确保计划的有效性。 行政核心还将促进与英国相关项目和中心的互动，以促进协同作用 和资源的协调。核心将促进中心的初级教师，研究人员， 来自英国各大学（农业、食品与环境;艺术与科学;工程;医学; 药房和其他），以创建一个充满活力的中心，无缝整合资源，人员和知识 跨越学科界限，促进科学创新和职业发展。

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research and Innovation at the University of Kentucky (UK). CPRI will serve as a comprehensive multidisciplinary center focused on translational chemical biology [the nexus of chemical biology (the application of chemical biology principles to develop validated probe/models to advance our understanding of biology) and pharmaceutical science (the application of pharmaceutical principles to advance leads/materials/devices that address unmet clinical needs)]. The COBRE will leverage and develop unique translational chemical biology research support infrastructure/expertise to facilitate junior faculty mentorship and career development, innovative biomedical research probe/tool/model/materials development and validation, and the early advancement of potential ‘translatable’ assets. Within this context, the CPRI Administrative Core will support center communication, coordination, oversight and integration of all COBRE operations, activities, projects, pilots and research support cores. The Core will provide fiscal management and resource oversight, overall coordination of mentoring and career development activities, resource allocation, and program evaluation to ensure program effectiveness. The Administrative Core will also facilitate interactions with related UK programs and centers to foster synergy and coordination of resources. The Core will facilitate the Center’s engagement of junior faculty, researchers, and mentors from UK Colleges (Agriculture, Food & Environment; Arts and Sciences; Engineering; Medicine; Pharmacy and others) to create a vibrant center that seamlessly integrates resources, personnel and knowledge across disciplinary boundaries, and fosters scientific innovation and career development.