THE THREE-DIMENSIONAL STRUCTURE OF CALC, A POTENT ANTIBIOTIC BINDING PROTEIN

CALC 的三维结构，一种有效的抗生素结合蛋白

• 批准号: 7598682
• 负责人: Jon Scott Thorson
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598682
• 关键词: Antibiotics; Antineoplastic Agents; Binding; Binding Proteins; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Drug Design; Funding; Grant; Institution; Proteins; Reaction; Research; Research Personnel; Resistance; Resources; Source; United States National Institutes of Health; pathogenic bacteria; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaboration is aimed at the determination of the three dimensional structure of the protein CalC, a small monomeric protein [1]. The 3D structure could yield valuable information for understanding the details of the very specific antibiotic binding and the subsequent reaction, for the design of drugs to overcome the resistance of pathogenic bacteria as well as for anticancer drugs.

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