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ENGINEERING METHYLTRANSFERASE INVOLVED IN THE BIOSYNTHESIS OF AT2433

ENGINEERING METHYLTRANSFERASE INVOLVED IN THE BIOSYNTHESIS OF AT2433
AT2433 生物合成中涉及的甲基转移酶工程
批准号:
7721682
负责人:
Jon Scott Thorson
金额:
$0.19万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-03-01 至 2009-02-28

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Methyltransferases (MTs) are one of the tailoring enzymes involved in the biosynthesis of natural products. By engineering the MTs to transfer groups other than methyl will have the potential to generate chemotherapeutics. In this project, we wish to carry out binding studies with synthetic cofactors in order to make the enzyme promiscuous.
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