Functional Immunomics Core

摘要(功能免疫组学核心) 功能免疫组学核心(FIC)的主要目标是充当 支持癌症免疫和免疫治疗中心(CCII)科布雷的所有研究人员。FIC 将利用机构资金购买的新设备，并利用加州大学的现有设施 路易斯维尔将为CCII中的小鼠和人类项目提供分子/细胞免疫图谱。特定的 目标1是在路易斯维尔大学建立一个功能免疫组学设施。在CCII的支持下，我们 将在中央位置建立一个简化的最先进的免疫组学设施，通过将 路易斯维尔大学的现有资源。这一独特的资源将作为一个重要的综合组成部分 通过不仅为其成员而且为该机构作为 完整的。具体目标2是利用全面和综合的FIC平台确保成功 CCII支持的项目。FIC的主要目标将是支持发展、进步和成功 拟议的CCII项目在其研究的所有阶段。特别是，FIC将提供人体样本 支持CCII项目具体目标的分析、专门知识和技术服务。具体目标3是 促进转化性癌症免疫学/免疫疗法研究，并发展一个自给自足的实体 CCII通过大学/地区范围的服务。总而言之，通过与 UofL，新成立的FIC将为成功提供全面的免疫组学服务中心 建议的CCII项目以及将新的实验发现转化为临床应用。

SUMMARY (Functional Immunomics Core) The primary goal of the Functional Immunomics Core (FIC) is to serve as the central infrastructure entity that supports all the investigators in the Center for Cancer Immunology and Immunotherapy (CCII) COBRE. FIC will utilize new equipment purchased with institutional funds and leverage existing facilities at the University of Louisville to provide molecular/cellular immune profiling for mouse and human projects in the CCII. Specific Aim 1 is to build a functional immunomics facility at the University of Louisville. With the support of CCII, we will establish a streamlined state-of-the-art immunomics facility in a central location by incorporating the existing resources of the University of Louisville. This unique resource will act as a vital integrative component of the CCII through providing centralized services not only for its members but also for the Institution as a whole. Specific Aim 2 is to utilize the comprehensive and integrative FIC platform to ensure the success of CCII-supported projects. The major goal of the FIC will be to support the development, progress and success of proposed CCII projects in all phases of their research. Particularly, the FIC will provide human sample analytics expertise and technical services to support the specific aims of the CCII projects. Specific Aim 3 is to facilitate translational cancer immunology/immunotherapy research and develop a self-sustaining entity of the CCII through University/region-wide services. In summary, by integrating with the existing resources at the UofL, the newly-established FIC will provide a comprehensive immunomics service center for the success of the proposed CCII projects and the translation of novel experimental discoveries to clinical applications.