Functional Immunomics Core

功能免疫组学核心（Functional Immunomics Core） 功能免疫组学核心（FIC）的主要目标是作为中央基础设施实体， 支持癌症免疫学和免疫治疗中心（CCII）COBRE的所有研究人员。FIC 将利用机构资金购买的新设备，并利用大学的现有设施， 路易斯维尔为CCII中的小鼠和人类项目提供分子/细胞免疫分析。具体 目标1是在路易斯维尔大学建立一个功能性免疫组学设施。在CCII的支持下，我们 将在中心位置建立一个精简的最先进的免疫组学设施， 路易斯维尔大学的现有资源。这一独特的资源将作为一个重要的综合组成部分， 通过不仅为其成员提供集中服务，而且还为该机构提供集中服务， 整体具体目标2是利用全面和综合的FIC平台，以确保 CCII支持的项目。FIC的主要目标是支持发展，进步和成功 在其研究的所有阶段，建议CCII项目。特别是，FIC将提供人体样本 分析专业知识和技术服务，以支持CCII项目的具体目标。具体目标3是 促进转化癌症免疫学/免疫治疗研究，并发展一个自我维持的实体， 通过大学/区域服务的CCII。总而言之，通过与现有资源相结合， UofL，新成立的FIC将提供全面的免疫组学服务中心， CCII项目的建议和新的实验发现的临床应用的翻译。

SUMMARY (Functional Immunomics Core) The primary goal of the Functional Immunomics Core (FIC) is to serve as the central infrastructure entity that supports all the investigators in the Center for Cancer Immunology and Immunotherapy (CCII) COBRE. FIC will utilize new equipment purchased with institutional funds and leverage existing facilities at the University of Louisville to provide molecular/cellular immune profiling for mouse and human projects in the CCII. Specific Aim 1 is to build a functional immunomics facility at the University of Louisville. With the support of CCII, we will establish a streamlined state-of-the-art immunomics facility in a central location by incorporating the existing resources of the University of Louisville. This unique resource will act as a vital integrative component of the CCII through providing centralized services not only for its members but also for the Institution as a whole. Specific Aim 2 is to utilize the comprehensive and integrative FIC platform to ensure the success of CCII-supported projects. The major goal of the FIC will be to support the development, progress and success of proposed CCII projects in all phases of their research. Particularly, the FIC will provide human sample analytics expertise and technical services to support the specific aims of the CCII projects. Specific Aim 3 is to facilitate translational cancer immunology/immunotherapy research and develop a self-sustaining entity of the CCII through University/region-wide services. In summary, by integrating with the existing resources at the UofL, the newly-established FIC will provide a comprehensive immunomics service center for the success of the proposed CCII projects and the translation of novel experimental discoveries to clinical applications.