DNA Damage Response and Oncogenic Signaling

项目摘要 癌症发病率的增加和癌症成本的上升突出了通过以下途径推进癌症生物学的必要性： 培养训练有素的劳动力。几乎所有的人类癌症都有信号通路的改变， 与DNA损伤反应和致癌信号传导有关，这些途径也是靶向治疗的重点 已经进入临床并正在研发中为了培养下一代癌症研究人员， 开发了一个机构范围内的癌症生物学博士后研究员培训计划，重点放在这一领域， 癌症研究，称为DNADRS计划。这个项目设在希望之城，一个国家癌症研究所指定的 综合癌症中心，该中心以临床癌症研究而闻名于国际， 基础癌症研究的杰出记录。这个T32计划始于2016年，这是第一次更新 应用程序. 3名T32支持的博士后培训生被选为DNADRS 通过严格的程序，包括个人面试。每个受训者建立一个指导 一个委员会，其中包括一名医生，以促进基础和翻译之间的思想交叉授粉 癌症研究方面。每年重新任命的依据是受训人员的年度书面报告， 指导委员会。作为DNADRS计划招聘激励措施的一部分，City of Hope将继续 为每一个被招募的代表性不足的少数民族实习生提供额外的博士后实习生职位， 共6个职位。此外，为了吸引全国最优秀的博士后候选人，City of Hope 继续承诺为所有DNADRS受训人员提供工资补贴，提供研究用品津贴， 行政和教师工资支持。学员将由18名教员指导，他们都是 从事以癌症为重点的高影响力研究，并有指导博士后研究员的历史。到 提高他们发展成为独立癌症研究人员的机会，所有DNADRS学员采取独特的 共同的课程，提供了一个连续的学习，包括科学课程，其中包括道德 开展研究和适当的研究设计，以及专业发展课程。此外，本发明还提供了一种方法， 学员参加前沿研究项目、期刊俱乐部、研讨会、专题讨论会、定期午餐会 与导师，指导委员会会议，国家和国际科学会议，最后， 年度DNADRS研讨会。恒星和全面的共享资源设施与 癌症中心提供最先进技术的培训。申请资金以更新这项研究 我们在上一个资助周期成功资助了七名学员， 三个代表性不足的少数民族研究员，研究培训对癌症的相关性， 导师，希望之城的杰出承诺，以及地理区域的多样化人口 由我们的机构提供服务。

Project Summary Increases in cancer incidence and rising cancer costs highlight the need to advance cancer biology through the growth of a well-trained workforce. Almost all human cancers have alterations in signaling pathways associated with DNA damage response and oncogenic signaling, and such pathways are also the focus of targeted therapies already in the clinic and under development. To train the next generation of cancer researchers, we have developed an institution-wide cancer biology training program for postdoctoral fellows focused on this area of cancer research, called the DNADRS program. This program is housed at the City of Hope, an NCI-designated Comprehensive Cancer Center, which is known internationally for clinical cancer research and has an outstanding record of basic cancer research. This T32 program began in 2016, and this is the first renewal application. The 3 T32-supported postdoctoral trainees supported for up to 3 years are selected for the DNADRS program through a rigorous process, including a personal interview. Each trainee establishes a mentoring committee that includes a physician to foster cross-pollination of ideas between the basic and translational aspects of cancer research. Annual reappointment is based on annual written reports from the trainee and mentoring committee. As part of a recruitment incentive in the DNADRS program, City of Hope will continue to provide an additional postdoctoral trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions. Furthermore, to attract the best postdoctoral candidates at a national level, City of Hope continues to commit to salary supplementation for all DNADRS trainees, a stipend for research supplies, and full administrative and faculty salary support. Trainees will be mentored by 18 faculty members, all of whom are performing cancer-focused high-impact research and have a history of mentoring postdoctoral fellows. To enhance their chances of developing into independent cancer researchers, all DNADRS trainees take a unique common curriculum that provides a continuum of learning including scientific coursework that includes ethical conduct of research and proper research design, as well as professional development courses. In addition, trainees participate in cutting-edge research programs, journal clubs, seminars, symposiums, regular luncheons with mentors, mentoring committee meetings, national and international scientific conferences, and finally a yearly DNADRS Symposium. The stellar and comprehensive Shared Resource Facilities associated with the Cancer Center provide training in state-of the art technologies. The request for funding to renew this research training grant is justified by our track-record from the last funding cycle of seven successful trainees that include three underrepresented minority fellows, the relevance of the research training to cancer, the experience of the mentors, the outstanding commitment of City of Hope, and the diverse population of the geographical area served by our institution.