DNA Damage Response and Oncogenic Signaling

项目摘要 癌症发病率的增加和癌症成本的上升突显了通过 训练有素的劳动力的增长。几乎所有的人类癌症都有相关信号通路的改变 与DNA损伤反应和致癌信号有关，这些通路也是靶向治疗的重点 已经在临床上，并正在开发中。为了培养下一代癌症研究人员，我们有 为博士后研究员制定了一个机构范围的癌症生物学培训计划，重点是这一领域 癌症研究，称为DNADRS计划。这个项目设在希望之城，一个由NCI指定的 综合性癌症中心，以临床癌症研究而闻名国际，拥有 杰出的癌症基础研究记录。这项T32计划始于2016年，这是第一次续签 申请。3名T32资助的博士后实习生最多支持3年，被选为DNADRS 计划通过一个严格的过程，包括个人面试。每个实习生都建立了一个指导 该委员会包括一名内科医生，以促进基础和翻译之间的思想交叉授粉 癌症研究的各个方面。年度续聘是基于受训人员的年度书面报告和 指导委员会。作为DNADRS计划招募激励的一部分，希望之城将继续 为每个招聘的代表不足的少数族裔实习生提供一个额外的博士后实习生职位，最高可达 总共有6个职位。此外，为了吸引国家一级最好的博士后候选人，希望之城 继续承诺为所有DNADRS实习生提供工资补充，为研究用品提供津贴，并 行政和教职员工工资支持。学员将由18名教职员工指导，他们都是 从事以癌症为重点的高影响力研究，并有指导博士后研究员的历史。至 提高他们发展成为独立癌症研究人员的机会，所有DNADRS实习生都采取了独特的 提供连续学习的公共课程，包括包括伦理道德在内的科学课程 进行研究和适当的研究设计，以及专业发展课程。此外, 学员参加前沿研究项目、期刊俱乐部、研讨会、座谈会、定期午餐会 与导师、指导委员会会议、国内和国际科学会议，以及最后一个 DNADRS年度研讨会。一流且全面的共享资源设施与 癌症中心提供最先进的技术培训。更新这项研究的资金申请 培训赠款是根据我们上一个资助周期的七名成功学员的记录来证明的，这些学员包括 三名代表不足的少数族裔研究员，研究培训与癌症的相关性， 导师，希望之城的杰出承诺，以及地理区域的多样化人口 由我们机构提供服务。

Project Summary Increases in cancer incidence and rising cancer costs highlight the need to advance cancer biology through the growth of a well-trained workforce. Almost all human cancers have alterations in signaling pathways associated with DNA damage response and oncogenic signaling, and such pathways are also the focus of targeted therapies already in the clinic and under development. To train the next generation of cancer researchers, we have developed an institution-wide cancer biology training program for postdoctoral fellows focused on this area of cancer research, called the DNADRS program. This program is housed at the City of Hope, an NCI-designated Comprehensive Cancer Center, which is known internationally for clinical cancer research and has an outstanding record of basic cancer research. This T32 program began in 2016, and this is the first renewal application. The 3 T32-supported postdoctoral trainees supported for up to 3 years are selected for the DNADRS program through a rigorous process, including a personal interview. Each trainee establishes a mentoring committee that includes a physician to foster cross-pollination of ideas between the basic and translational aspects of cancer research. Annual reappointment is based on annual written reports from the trainee and mentoring committee. As part of a recruitment incentive in the DNADRS program, City of Hope will continue to provide an additional postdoctoral trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions. Furthermore, to attract the best postdoctoral candidates at a national level, City of Hope continues to commit to salary supplementation for all DNADRS trainees, a stipend for research supplies, and full administrative and faculty salary support. Trainees will be mentored by 18 faculty members, all of whom are performing cancer-focused high-impact research and have a history of mentoring postdoctoral fellows. To enhance their chances of developing into independent cancer researchers, all DNADRS trainees take a unique common curriculum that provides a continuum of learning including scientific coursework that includes ethical conduct of research and proper research design, as well as professional development courses. In addition, trainees participate in cutting-edge research programs, journal clubs, seminars, symposiums, regular luncheons with mentors, mentoring committee meetings, national and international scientific conferences, and finally a yearly DNADRS Symposium. The stellar and comprehensive Shared Resource Facilities associated with the Cancer Center provide training in state-of the art technologies. The request for funding to renew this research training grant is justified by our track-record from the last funding cycle of seven successful trainees that include three underrepresented minority fellows, the relevance of the research training to cancer, the experience of the mentors, the outstanding commitment of City of Hope, and the diverse population of the geographical area served by our institution.