Developmental Funds

项目摘要--发展基金 OSUCCC为教师招聘和共享资源开发提供了种子资金。在.期间 在本赠款周期内，招聘了17名教职员工，其中8人为副教授或正教授。这些 所有5个研究项目的教职员工都是有战略地招募的，主要集中在与 OSUCCC集水区。他们跨越了5个不同的学院，10个不同的院系，以及 包括全国儿童医院。用于支持这些教师的发展资金为1,937,467美元。 这些调查人员获得了32,567,789美元的NCI资金和35,813,889美元的同行审查资金，产生了 CCSG发展基金的投资回报率为18：1。对于本资金周期，我们还建立了 两个正在开发的共享资源(在先前的CCSG指南中允许)，这是实体肿瘤 翻译开发共享资源(STTdSR)与兽医临床研究支持开发 共享资源(VCRSdSR)。STTdSR已经成熟，现在被称为临床-转译科学 共享资源(CTSSR)以反映更广泛的使用，以包括专注于血液学的研究人员 除了那些从事实体肿瘤研究的人外，还有恶性肿瘤和人口科学。为此共享的资金 当前CCSG应用程序中请求了资源。VCRSdSR仍然是一个发展中的共享资源； 然而，这将得到机构资金的支持，不要求CCSG提供资金。具体目标 用于发展的资金是：1)扩大创新和高影响力的科学，重点是我们的四个战略 优先事项：免疫肿瘤学、癌症工程学、翻译基因组学、癌症预防和 生存能力；2)确定和招聘科学专长为目标的高级、中级和早期职业教师 OSUCCC战略计划和集水区(CA)的相关需求；以及，3)使用可靠的评估 为方案间合作和/或符合以下条件的研究项目提供种子资金 以社区为重点，导致NCI的资金达到R01-或P01-等值水平。为了实现这些目标，对于 根据目前的申请，正在申请资金，用于征聘与以下方面匹配的调查员(n=18) OSUCCC的研究优先事项以及方案和集水领域的需要。OSUCCC还要求 资金，以利用我们非常成功的由佩洛托尼亚资助的试点奖励计划，称为校内研究 程序。这是一个外部同行评审的机制，根据科学数据确定资助项目的优先顺序。 优点和研究集中在我们的集水区，并为早期调查人员提供额外考虑。 CSSG试点资金将专门针对跨越两个或更多研究项目的协同项目 代表方案间协作，和/或发展社区伙伴关系的项目(资金 用于在共享资源管理预算中申请新的共享资源)。发展基金 CCSG评审过程是我校评估OSUCCC和 使我们能够充分利用我们正在进行的和实质性的机构承诺。

PROJECT SUMMARY – DEVELOPMENTAL FUNDS The OSUCCC has provided seed funding for faculty recruitment and shared resource development. During the current grant cycle, 17 faculty were recruited, 8 of which were at the associate or full professor level. These faculty were strategically recruited to all 5 research programs and most focus on research relevant to the OSUCCC catchment area. They span 5 different colleges, 10 different departments across the colleges, and include Nationwide Children’s Hospital. Developmental funds used to support these faculty was $1,937,467. These investigators received $32,567,789 in NCI funding and $35,813,889 total peer-review funding, yielding a return on investment from CCSG developmental funds of 18:1. For the current funding cycle, we also established two developing shared resources (permitted under the prior CCSG guidelines), which were the Solid Tumor Translational developing Shared Resource (STTdSR) and the Veterinary Clinical Research Support Developing Shared Resource (VCRSdSR). The STTdSR has matured and is now called the Clinical-Translational Science Shared Resource (CTSSR) to reflect more broad use to include investigators focused on hematological malignancies and population science, in addition to those doing solid tumor research. Funding for this shared resource is requested in the current CCSG application. The VCRSdSR remains a developing shared resource; however, this will be supported from institutional funds and no CCSG funding is requested. The Specific Aims for Developmental Funds are: 1) to expand innovative and high-impact science focused on our four strategic priorities: immuno-oncology, cancer engineering, translational genomics, and cancer prevention and survivorship; 2) to identify and recruit senior, midlevel and early career faculty whose scientific expertise targets relevant needs in the OSUCCC strategic plan and catchment area (CA); and, 3) to use a robust evaluation process and provide seed funding for research projects that are inter-programmatic collaborations and/or are community focused, leading to NCI funding at the R01- or P01-equivalent level. To achieve these aims, for the current application, funds are being requested for the recruitment of investigators (n=18) matched to the OSUCCC research priorities and programmatic and catchment area needs. The OSUCCC also is requesting funding to leverage our highly successful Pelotonia-funded pilot awards program, called the Intramural Research Program. This is an externally peer reviewed mechanism that prioritizes projects for funding based on scientific merit and research focused on our catchment area, with additional consideration for early stage investigators. CSSG pilot funding will specifically target synergistic projects spanning two or more research programs representing inter-programmatic collaborations, and/or or projects developing community partnerships (funding for new shared resources are requested in the Shared Resource Management budget). Developmental funds and the CCSG review process are a critical way that our university evaluates the impact of the OSUCCC and allows us to substantially leverage our ongoing and substantial institutional commitments.