SARC Sarcoma SPORE

描述（由申请人提供）：该申请代表了优秀机构、主要肉瘤专门非营利组织和 NCI 校内计划之间前所未有的合作。该 SPORE 源自 SARC，这是一个非营利性联盟，旨在促进国家肉瘤卓越中心之间的研究开展。 SARC 肉瘤孢子的主要目标是将生物和技术进步转化为预防、诊断、结果预测的改进，特别是肉瘤治疗方面的进步。 SARC 肉瘤 SPORE 由来自 SARC、哈佛大学、MD 安德森癌症中心和 NCI 校内项目的多名研究人员主持，还包括来自斯坦福大学、哥伦比亚大学和密歇根大学的关键个人研究人员。研究人员代表医学和儿科肿瘤学，这些项目探索软组织和骨肉瘤。提出了四个主要项目：1）基于 HDACi 的治疗策略，用于治疗遗传复杂的 STS； 2）确定NFI相关恶性周围神经鞘瘤的治疗窗； 3) 研究G蛋白偶联受体作为尤文肉瘤侵袭性疾病的生物标志物和新的治疗靶点； 4)开发定量成像生物标志物，用于使用PET和MRl中的先进方法评估对肉瘤治疗的治疗反应。这些项目由 4 个核心整合和支持：1）管理、评估和规划； 2）组织与病理学； 3）临床试验； 4) 生物统计学。 SPORE 申请概述了一项发展研究计划，其中包括新项目选择计划以及 14 个拟议的发展试点项目。我们还包括一项职业发展计划，概述了一种机制，用于识别和支持转化或临床肉瘤研究中有才华的年轻研究人员。这些项目、核心和计划高度集成，并准备充分利用 SPORE 机制来实现转化目标。该 SPORE 将最先进的研究项目与 SARC 的多机构协作力量以及领先机构的承诺结合起来，以产生转化性进展。

DESCRIPTION (provided by applicant): This application represents unprecedented cooperation among excellent institutions, major sarcoma dedicated non-profit organizations, and the NCI intramural Program. This SPORE originates from SARC, a non-for-profit consortium that facilitates the conduct of research among national centers of excellence in sarcoma. The main goals of the SARC Sarcoma SPORE are the translation of biological and technological advances into improvements in prevention, diagnostics, predictors of outcome, and - particularly - advances in the treatment of sarcoma. The SARC Sarcoma SPORE is anchored by multiple researchers from SARC, Harvard, MD Anderson Cancer Center, and the NCI intramural program, but also includes key individual researchers from Stanford University, Columbia University and The University of Michigan. The researchers represent medical and pediatric oncology and the projects explore both soft tissue and bone sarcomas. Four major projects are proposed: 1) HDACi-based therapeutic strategies for the treatment of genetically complex STS; 2) Identification of therapeutic windows for NFI-related malignant peripheral nerve sheath tumor; 3) Investigation of G-protein coupled receptors as biomarkers of aggressive disease and novel therapeutic targets in Ewing sarcoma; and 4) Development of quantitative imaging biomarkers for assessing therapeutic response to sarcoma therapy using advanced approaches in PET and MRl. These projects are integrated and supported by 4 cores: 1) Administration, Evaluation and Planning; 2) Tissue and Pathology; 3) Clinical Trials; and 4) Biostatistics. The SPORE application outlines a Developmental Research Program that includes a plan for selection of new projects as well as 14 proposed developmental pilot projects. We also include a Career Developmental Program that outlines a mechanism for the identification and support of talented young investigators in translational or clinical sarcoma research. The projects, cores and programs are highly integrated and are poised to take maximum advantage of the SPORE mechanism to achieve translational goals. This SPORE joins state-of-the-art research projects with the multi-institution, collaborative strength of SARC and commitments from leading institutions to produce translational advances.