Program 07 Cancer Epidemiology

癌症流行病学项目 项目摘要/摘要 癌症流行病学计划(CEP)的使命是促进和开展创新的流行病学 与癌症相关的研究，并支持将研究结果转化为有意义的癌症进展 预防、筛查、诊断和治疗。一个关键的规划目标是整合癌症 横跨癌症中心疾病和学科项目的流行病学研究。因此，国际- 程序化的合作导致了流行病学研究成果向前瞻性的“正向转化”。 临床试验和对探索细胞和分子机制的实验室研究的反向转换 潜在的流行病学观察。该计划深深投入到培训和培训的使命中 指导代表下一代癌症的学生、博士后和临床研究员 流行病学家，特别是来自代表性不足的少数族裔背景的受训人员。 该方案的68名成员(50名主要成员和18名次要成员)代表了所有7个DF/CC机构和12个 学术部门。2019年，用于该方案的同行审查赠款资金为1,150万美元 NCI的直接成本和其他赞助商的380万美元。在本供资期间，主要的CEP 成员发表了1093篇与癌症相关的论文。其中，47%是机构间的，46%是机构内的 方案和40%是两个或更多DF/CC成员之间的方案间协作。 这些数字反映了CCSG结构和高级领导人推动的互动的广度。 计划成员解决癌症死亡率的病因学问题，包括生活方式因素，以及 预测性和预测性生物标志物研究。该计划强调在我们的优先领域的研究目标 NCI 2022年年度计划中概述的集水区、DF/HCC战略计划和科学重点 (肥胖与癌症；癌症存活期)。在下一个CCSG资助期，我们的具体目标是 在以下领域加速科学、合作、翻译和培训：(1)能量平衡， 代谢和癌症；(2)危险因素和癌症亚型；(3)分子和基因组生物标记物 癌症；(4)与癌症死亡有关的因素。

Cancer Epidemiology Program Project Summary / Abstract The mission of the Cancer Epidemiology Program (CEP) is to facilitate and conduct innovative epidemiology research related to cancer and to support translation of the findings into meaningful advances in cancer prevention, screening, diagnosis, and treatment. A key programmatic goal is the integration of cancer epidemiology research across the Cancer Center’s disease- and discipline-based Programs. As a result, inter- programmatic collaborations have led to the ‘forward translation’ of epidemiologic findings into prospective clinical trials and ‘reverse translation’ to laboratory studies that explore the cellular and molecular mechanisms underlying epidemiologic observations. The Program is deeply invested in the mission of training and mentoring students and postdoctoral and clinical fellows who represent the next generation of cancer epidemiologists, especially trainees from underrepresented minority backgrounds. The Program’s 68 members (50 primary and 18 secondary) represent all seven DF/HCC institutions and 12 academic departments. In 2019, peer-reviewed grant funding attributed to the Program was $11.5 million in direct costs from the NCI and $3.8 million from other sponsors. During the current funding period, primary CEP members published 1,093 cancer-relevant papers. Of these, 47% were inter-institutional, 46% were intra- programmatic and 40% were inter-programmatic collaborations between two or more DF/HCC members. These numbers reflect the breadth of interactivity promoted by the CCSG structure and senior leaders. Program members tackle etiological questions in cancer mortality, including lifestyle factors, as well as predictive and prognostic biomarker studies. The Program emphasizes research goals in priority areas of our catchment area, the DF/HCC strategic plan, and scientific focus outlined in the NCI’s 2022 Annual Plan (obesity and cancer; cancer survivorship). For the next CCSG funding period, our Specific Aims are to accelerate science, collaboration, translation, and training in the following areas: (1) Energy balance, metabolism, and cancer; (2) Risk factors and cancer subtypes; (3) Molecular and genomic biomarkers in cancer; and (4) Factors associated with cancer mortality.