Cancer Epidemiology Cohort in Male Health Professionals

这一竞争性续订应用程序的目标是支持核心基础架构和后续运行状况 专业人员跟踪研究(HPFS)，这是一个由51,529名美国男性健康专业人员组成的癌症流行病学队列 按1986年基线计算，年龄在40至75岁之间。这一群体在关注男性健康方面是独一无二的，已经35岁了 随访，为研究癌症发病率的可改变危险因素提供了一个必要的时间框架，具有现实意义 延迟。关于饮食、体力活动、吸烟、体重、药物和 癌症风险的其他潜在可改变的决定因素。生物信息库是队列的关键要素， 包括DNA、红细胞、血浆、粪便和脚趾甲。从7522起事件中获得了肿瘤组织 前列腺癌、结肠癌、膀胱癌、肾癌和肺癌(非吸烟者)，以及血液系统癌症。队列 在每两年的周期中，随访率始终为90%，死亡率随访期几乎完成。目前， 21,853名参与者生活在癌症高发年龄；这些将是最有信息量的 从中年开始提供广泛暴露数据的病例。在目前的资助中，发表了492篇论文，这些论文利用 来自HPFS的数据和/或生物样本；其中317个专门检查了癌症或先兆结果 包括由外部调查人员牵头的&gt；100。到目前为止，已有17,091名参与者被诊断出癌症 已有4704人死于癌症；7061名男性目前被诊断患有癌症。 在下一个资金周期中，我们提出了以下目标：目标1.积极跟踪癌症 发病率和死亡率；更新癌症诊断前后的暴露情况；目标2.收集关于以下方面的数据 癌症幸存者的生活质量、治疗、进展和大麻使用。目标3.更新食物 支持HPFS和外部研究的成分和营养数据库；联合校准膳食 与南方社区队列研究(SCCS)的问卷调查，以支持联合研究。目标4.目标 维护和扩展HPFS组织生物存储库，以收集来自前列腺、结肠、肺、肾和 膀胱癌；试验人工智能方法以表征前列腺的形态特征 肿瘤。目标5.维护其他生物库，包括血浆、红细胞、脚趾甲和生殖系 DNA目标6.扩大HPFS和SCCS参与者的地理编码地址的联系，以评估纵向 三十年来对建成环境和邻近地区SES的测量。目标7.维护和维护 通过内部和外部加强统计基础设施和数据管理，以支持HPFS分析 调查人员；开发新软件以促进HPFS和共享中的延迟和竞争风险分析 与外部调查人员合作。目标8.促进资源共享和与外部调查人员的合作 和联合体，包括将HPFS调查问卷数据文件传输到安全云环境。使用 额外的后续行动，包括癌症诊断后，HPFS仍然是创新的理想定位 通过确定一级和二级预防战略，为我们减少癌症负担的目标作出贡献。

The goal of this competing renewal application is to support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 U.S. male health professionals age 40 to 75 years at baseline in 1986. This cohort is unique in its focus on men’s health and with 35 years follow-up, provides a time frame essential to study modifiable risk factors for cancer incidence with realistic latencies. Information has been regularly updated on diet, physical activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. The biorepository is key element of the cohort and includes DNA, red blood cells, plasma, stool, and toenails. Tumor tissue has been obtained from 7,522 incident cancers of the prostate, colon, bladder, kidney, and lung (nonsmokers), and hematologic cancers. Cohort follow-up is consistently 90% at each two-year cycle and mortality follow-up is virtually complete. At present, 21,853 participants are living and at a heightened age of cancer incidence; these will be the most informative cases given extensive exposure data since midlife. In the current grant, 492 papers were published that utilize data and/or biological samples from HPFS; 317 of these specifically examined cancer or precursor outcomes including >100 led by external investigators. To date, 17,091 participants have been diagnosed with cancer and 4,704 cancer deaths have occurred; 7,061 men are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims: Aim 1. To actively follow-up for cancer incidence and mortality; to update exposures pre- and post-diagnosis of cancer; Aim 2. To collect data on quality of life, treatment, progression, and cannabis use among cancer survivors. Aim 3. To update the food composition and nutrient databases that support the HPFS and external studies; to jointly calibrate dietary questionnaires with the Southern Community Cohort Study (SCCS) to support combined studies. Aim 4. To maintain and expand the HPFS tissue biorepository to collect tissue from prostate, colon, lung, kidney, and bladder cancers; to pilot artificial intelligence approaches to characterize morphologic features of prostate tumors. Aim 5. To maintain other biorepositories including plasma, red blood cells, toenails, and germline DNA. Aim 6. To expand linkage of geocoded addresses of HPFS and SCCS participants to assess longitudinal measures of the built environment and neighborhood SES over three decades. Aim 7. To maintain and augment the statistical infrastructure and data management to support HPFS analyses by internal and external investigators; to develop new software to facilitate latency and competing risk analyses in HPFS and share with external investigators. Aim 8. To facilitate resource sharing and collaborations with external investigators and consortia, including the transfer of HPFS questionnaire datafiles onto a secure cloud environment. With additional follow-up, including after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our goal of reducing cancer burden by identifying primary and secondary prevention strategies.