Cancer Epidemiology Cohort in Male Health Professionals

项目摘要 此竞争性更新应用程序的目标是支持核心基础设施和持续跟进 卫生专业人员随访研究（HPFS），1986年建立的癌症流行病学队列（CEC） 包括51，529名男性卫生专业人员，基线年龄为40至75岁。这个群体是独一无二的， 关注男性健康和近三十年的随访，这一时间框架对于现实地 了解可变因素与癌症风险之间的关系。在此期间，数据 定期更新饮食、活动、吸烟、体重、药物和其他可能改变的决定因素 癌症风险。已经建立了一个广泛的生物储存库，其中包括来自大多数参与者的DNA， 脚趾甲红细胞和血浆肿瘤组织已从高比例的前列腺肿瘤中获得。 和结直肠癌;最近的补充是支持收集组织不太常见的肿瘤， 非癌性前列腺组织队列随访在每个两年周期中始终达到90%或更高 死亡率的追踪也基本完成了来自HPFS的流行病学研究，单独和通过 参与联盟，有助于阐明癌症发病率的风险因素和癌症的决定因素 男人的生存。随着队列成员现在处于癌症高发年龄，HPFS处于高度 生产阶段。在当前的资助周期内，已经发表了325篇利用数据和/或 来自HPFS的生物样本;其中200个专门检查了癌症或癌症前体结果。 迄今为止，已有13，346名参与者被诊断患有癌症，3，571人死于癌症; 5，791人死于癌症。 HPFS中的男性目前患有癌症诊断。在下一个供资周期，我们提出以下建议 目标。1-)继续积极跟踪癌症发病率和死亡率，并更新 癌症诊断后。2-)更新食物成分数据库，以支持 HPFS和护士健康研究I和II队列。3-)利用最近完成的验证研究， 身体活动，并与两个多种族男性队列的同事合作， 问题. 4-)第一时间链接到Medicare索赔数据。5-)为了维持HPFS癌组织 生物储存库，扩大前列腺和结肠的收集，并进行新的肺癌收集， 不吸烟的人。6-)为了维持其他生物储存库，包括血浆、红细胞、生殖系DNA， 脚趾甲样本7-)在前列腺癌男性患者中进行新的诊断后采血。8-） 维护和加强队列的统计基础设施和数据管理。9-)以促进 与其他CEC和外部研究者的资源共享和合作。加上后续的队列- 特别是在癌症诊断之后，HPFS仍然处于理想的位置，可以为 我们的总体目标是通过确定一级和二级预防战略来减轻癌症负担。

PROJECT SUMMARY The goal of this competing renewal application is to support the core infrastructure and continued follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort (CEC) established in 1986 and including 51,529 male health professionals age 40 to 75 years at baseline. This cohort is unique in its focus on men's health and follow-up of almost three decades, a time frame that is essential to realistically understand the relation between modifiable factors and cancer risk. Over this period of time, data has been regularly updated on diet, activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. An extensive biorepository has been established that includes DNA from most participants, toenails, red cells, and plasma. Tumor tissue has been obtained from a high percentage of incident prostate and colorectal cancers; a recent supplement is supporting collection of tissue for less common tumors and noncancerous prostate tissue. Cohort follow-up has been consistently 90% or higher at each two-year cycle and mortality follow-up is virtually complete. Epidemiological studies from the HPFS, alone and through participation in consortia, have helped elucidate risk factors for cancer incidence and determinants of cancer survival in men. With cohort members now in an age of high cancer incidence, the HPFS is in a highly productive phase. During the current funding cycle, 325 papers have been published that utilize data and/or biological samples from HPFS; 200 of these have specifically examined cancer or cancer precursor outcomes. To date, 13,346 participants have been diagnosed with cancer and 3,571 cancer deaths have occurred; 5,791 men in HPFS are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims. 1-) To continue active follow-up for cancer incidence and mortality and to update exposure data pre and post-diagnosis of cancer. 2-) To update the food composition database that supports dietary assessment in HPFS and the Nurses' Health Study I and II cohorts. 3-) To leverage a recently completed validation study of physical activity and collaborate with colleagues in two multiethnic cohorts of men to calibrate physical activity questions. 4-) To make a first time linkage to Medicare Claims data. 5-) To maintain the HPFS cancer tissue biorepository, and expand collections of prostate and colon, and undertake a new collection of lung cancer in nonsmokers. 6-) To maintain the other biorepositories including plasma, red blood cells, germline DNA, and toenail samples. 7-) To undertake a new post-diagnostic blood collection among men with prostate cancer. 8-) To maintain and augment the statistical infrastructure and data management of the cohort. 9-) To facilitate resource sharing and collaborations with other CECs and outside investigators. With additional cohort follow- up, particularly after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our overall goal of reducing the burden of cancer by identifying primary and secondary prevention strategies.