Spousal Influences on Subclinical and Clinical Vascular and Myocardial Disease

配偶对亚临床和临床血管和心肌疾病的影响

基本信息

  • 批准号:
    10333819
  • 负责人:
  • 金额:
    $ 34.09万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-15 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT: Project 4 (Lead: Patel; Early Stage Investigator) Spouse lifestyle choices and psychosocial characteristics may powerfully influence the other spouse’s cardiovascular disease (CVD) risk milieu. We have compelling preliminary baseline data from the Center for cArdiometabolic Risk Reduction in South Asia Cohort (CARRS) that the odds of overweight, hypertension, diabetes, and depression are twice as high in adults who have a spouse with those same conditions. These cross-sectional associations of spousal CVD risks raise questions regarding whether development of CVD in one spouse can assist in more precisely predicting future risk of CVD in the partner. Identifying the mechanisms of specific spousal influences on CVD development may inform contextually-tailored, family-level interventions to target modifiable CVD risk factors. In Project 4 of Precision-CARRS, we will investigate spouse dyads already enrolled in the CARRS cohort to better understand the independent influence of spouses on the natural history of subclinical and clinical vascular and myocardial disease. CARRS is a large and diverse community-based cohort of 21,864 South Asian adults aged ≥ 20 years residing in Delhi and Chennai, India. By design, one randomly selected man and woman per sampled household were recruited at baseline, yielding 5,931 spouse dyads (n= 11,862 adults; 54% of the cohort), followed for up to 10 years (median: 5 years). Through Precision-CARRS, we will utilize repeated measures of traditional atherosclerotic CVD (ASCVD) risk factors collected since baseline, novel phenotyping of subclinical and clinical CVD disease (CVD phenotyping Core). In addition, Project 4 will collect new, real-time data on sleep characteristics, physical activity levels, diet, and psychosocial factors over a 7-day observation period using low-burden mHealth technologies (wearable wristband tracker and smartphone application; n=1,500 spousal dyads). Analyses will account for individual-level risk factors and also quantify the role of shared environmental risk factors such as built environment and air pollution (Project 2) in the development of CVD risk. Our aims are to: Aim 1. Evaluate spousal influences on ASCVD risk factors. Aim 2. Determine the relationship between spousal CVD measures and subclinical and clinical vascular disease and myocardial disease. Aim 3. Evaluate interpersonal mechanisms of spousal influences by examining day-to-day associations in health behaviors and psychosocial measures that are risk factors for CVD in a subsample of 1,500 dyads. Project 4, led by an Early Stage Investigator, adds to Precision-CARRS by identifying how the development of CVD—from early risk to clinically manifest disease—is independently influenced by one’s spouse. Expanding CVD risk assessment to include spouse’s CVD related behaviors and outcomes will highlight pathways for risk reduction and may inform more precise and early identification of CVD.
项目摘要/摘要:项目 4(负责人:Patel;早期研究员) 配偶的生活方式选择和心理社会特征可能会强烈影响另一方的 心血管疾病 (CVD) 风险环境。我们有来自该中心的令人信服的初步基线数据 南亚队列心脏代谢风险降低 (CARRS) 表明超重、高血压、 配偶患有相同疾病的成年人患糖尿病和抑郁症的几率是其两倍。这些 配偶 CVD 风险的横断面关联提出了以下问题: 配偶一方可以帮助更准确地预测伴侣未来患 CVD 的风险。识别 特定配偶对 CVD 发展影响的机制可能会根据具体情况、家庭层面提供信息 针对可改变的 CVD 危险因素的干预措施。 Precision-CARRS项目4,我们将调查配偶 已经加入 CARRS 队列的夫妻可以更好地了解配偶对家庭的独立影响 亚临床和临床血管和心肌疾病的自然史。 CARRS 是一个庞大且多样化的 基于社区的队列,由居住在印度德里和金奈的 21,864 名 20 岁以上南亚成年人组成。经过 设计中,每个样本家庭在基线时随机选择一名男性和一名女性,得出 对 5,931 名配偶(n= 11,862 名成年人;占队列的 54%)进行了长达 10 年的随访(中位数:5 年)。 通过 Precision-CARRS,我们将利用传统动脉粥样硬化 CVD (ASCVD) 风险的重复测量 自基线以来收集的因素、亚临床和临床 CVD 疾病的新表型(CVD 表型 核)。此外,项目 4 将收集有关睡眠特征、体力活动水平、 使用低负担移动医疗技术在 7 天观察期内的饮食和心理社会因素 (可穿戴腕带跟踪器和智能手机应用程序;n=1,500 配偶)。分析将考虑 个人层面的风险因素,并量化共同环境风险因素的作用,例如建筑 CVD风险发展中的环境和空气污染(项目2)。我们的目标是: 目标 1. 评估 配偶对 ASCVD 危险因素的影响。目标 2. 确定配偶 CVD 措施之间的关系 以及亚临床和临床血管疾病和心肌疾病。目标 3. 评估人际关系 通过检查健康行为和心理社会的日常关联来研究配偶影响的机制 在 1,500 对子样本中作为 CVD 风险因素的测量值。项目 4,由早期阶段领导 研究人员通过确定 CVD 的发展(从早期风险到临床)对 Precision-CARRS 进行了补充 明显的疾病——独立地受到配偶的影响。扩大 CVD 风险评估范围,包括 配偶的 CVD 相关行为和结果将突出降低风险的途径,并可能提供更多信息 准确、早期识别 CVD。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Shivani A Patel其他文献

The Context of Hypertension Management in India: A National Assessment of the Potential for Digital Technology Interventions in the Public Health Care System
印度高血压管理的背景:对公共卫生保健系统数字技术干预潜力的全国评估
  • DOI:
    10.21203/rs.3.rs-125013/v1
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0.3
  • 作者:
    Shivani A Patel;K. Vashist;P. Jarhyan;H. Sharma;Priti Gupta;Devraj Jindal;Nikhil Srinivasapura Venkateshmur;L. Pfadenhauer;S. Mohan;N. Tandon
  • 通讯作者:
    N. Tandon
Historical Redlining and Heart Failure Outcomes Following Hospitalization in the Southeastern United States.
美国东南部住院后的历史红线和心力衰竭结果。
Association of Psychosocial Risk Factors With Quality of Life and Readmissions 1-Year After LVAD Implantation.
心理社会风险因素与 LVAD 植入后 1 年生活质量和再入院的关联。
  • DOI:
    10.1016/j.cardfail.2024.03.011
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Jeffrey H. Wang;Alexis Okoh;Yuxuan Chen;R. Steinberg;Apoorva Gangavelli;Krishan Patel;Yi;Jeffrey D Alexis;Shivani A Patel;David J Vega;Mani Daneshmand;E. DeFilippis;Khadijah Breathett;Alanna A Morris
  • 通讯作者:
    Alanna A Morris
Self-concept and intrinsic motivation in foreign language learning: The connection between flow and the L2 self
外语学习中的自我概念与内在动机:心流与二语自我的联系
  • DOI:
    10.3389/feduc.2022.975163
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    Jacob M. Marszalek;Diane Balagna;Alissa K. Kim;Shivani A Patel
  • 通讯作者:
    Shivani A Patel
Poor Medication Access as a Driver of Excess Heart Failure Readmissions Among Patients Living in Economically Deprived Neighborhoods.
药物获取不畅是生活在经济贫困社区的患者心力衰竭再入院率过高的一个原因。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Apoorva Gangavelli;Zihao Liu;Jeffrey H. Wang;Alexis Okoh;R. Steinberg;Krishan Patel;Shivani A Patel;Neal W. Dickert;A. Morris
  • 通讯作者:
    A. Morris

Shivani A Patel的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Shivani A Patel', 18)}}的其他基金

The Impact of the COVID-19 Pandemic Environment on Cardiometabolic Health
COVID-19 大流行环境对心脏代谢健康的影响
  • 批准号:
    10660485
  • 财政年份:
    2023
  • 资助金额:
    $ 34.09万
  • 项目类别:
Spousal Influences on Subclinical and Clinical Vascular and Myocardial Disease
配偶对亚临床和临床血管和心肌疾病的影响
  • 批准号:
    10622482
  • 财政年份:
    2022
  • 资助金额:
    $ 34.09万
  • 项目类别:

相似海外基金

Affective Computing Models: from Facial Expression to Mind-Reading
情感计算模型:从面部表情到读心术
  • 批准号:
    EP/Y03726X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Standard Grant
Affective Computing Models: from Facial Expression to Mind-Reading ("ACMod")
情感计算模型:从面部表情到读心术(“ACMod”)
  • 批准号:
    EP/Z000025/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Research Grant
Interface: Transplants, Aesthetics and Technology (Previously About Face: The affective and cultural history of face transplants)
界面:移植、美学和技术(之前关于面部:面部移植的情感和文化历史)
  • 批准号:
    MR/Y011627/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Fellowship
Individual differences in affective processing and implications for animal welfare: a reaction norm approach
情感处理的个体差异及其对动物福利的影响:反应规范方法
  • 批准号:
    BB/X014673/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Research Grant
Affective and Immaterial Labour in Latin(x) American Culture
拉丁美洲文化中的情感和非物质劳动
  • 批准号:
    AH/V015834/2
  • 财政年份:
    2023
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Fellowship
Home/bodies: Exploring the affective experiences of people at home using scenographic practice and ecological thinking
家/身体:利用场景实践和生态思维探索人们在家中的情感体验
  • 批准号:
    2888014
  • 财政年份:
    2023
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Studentship
Imagination under Racial Capitalism: the Affective Salience of Racialised and Gendered Tropes of 'Black excellence'
种族资本主义下的想象力:“黑人卓越”的种族化和性别化比喻的情感显着性
  • 批准号:
    2889627
  • 财政年份:
    2023
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Studentship
Tracing the brain mechanisms of affective touch.
追踪情感触摸的大脑机制。
  • 批准号:
    23K19678
  • 财政年份:
    2023
  • 资助金额:
    $ 34.09万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了