Molecular and cellular determinants of Drosophila larva thermotaxis
果蝇幼虫趋热性的分子和细胞决定因素
基本信息
- 批准号:10334428
- 负责人:
- 金额:$ 53.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-15 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnatomyAnimalsAreaAutomobile DrivingBehaviorBehavioralBrainBrain regionCellsChemicalsCollaborationsComplexCuesDataDorsalDrosophila genusElementsFamilyGeneticGoalsImageIndividualInterneuron functionInterneuronsInvestigationLarvaLobeMapsMediatingModalityMolecularMolecular GeneticsNervous system structureNeuronsNeurosciencesOdorsOlfactory PathwaysOrganOutputPeripheralPhysiologicalPhysiologyProcessPropertyResearch PersonnelResolutionRoleSensoryShapesSmell PerceptionStereotyped BehaviorStimulusSynapsesSystemTaste PerceptionTemperatureTestingTextureThermoreceptorsTransducersbehavioral responsecognitive functionconnectomedifferential expressionfeedingflexibilitygenetic manipulationin vivoin vivo imaginginformation processinginsightmultilevel analysismultisensorymutantneural circuitreceptorresponsesensorsensory inputsensory integrationsensory mechanismtool
项目摘要
Project Summary
Molecular and cellular determinants of Drosophila larva thermotaxis
How nervous systems detect and integrate multiple sensory cues to generate robust behaviors is a major
question in neuroscience. Such integration is particularly salient in thermosensing, as animals are frequently
required to integrate input from multiple thermoreceptor classes. Temperature's ubiquity also means input from
other modalities (e.g., olfaction) is commonly received in the context of ongoing thermosensory stimulation.
Achieving a comprehensive understanding of the molecular and circuit mechanisms underlying the integration
of information from multiple sensors remains a challenge. We will address this challenge in the Drosophila
larva. Its ease of genetic manipulation, synaptic-resolution connectome of thermosensory and olfactory
processing areas, amenability to neuronal imaging, and stereotyped behaviors, all make it a favorable system
for a comprehensive molecular and circuit level investigation of the mechanisms of sensory integration. We
propose to achieve these goals in three aims:
Aim 1) Establish the molecular and cellular receptors that provide thermosensory input
In aims 1.a. and 1.b., we will identify the molecular basis of thermosensing by thermosensory neurons in the
larval Dorsal Organ and examine their roles in guiding behavior through cell-specific inhibition and activation
combined with high-resolution behavioral analysis.
Aim 2) Probe the activities of the interneurons that process thermosensory input
In aim 2.a., we will examine how thermosensory inputs act to modulate the neuronal activity of individually
identifiable downstream projection neurons revealed from the larval antennal lobe connectome. This will
establish the manner in which peripheral sensory input influences these second-order interneurons. In aim
2.b., we will investigate how thermosensory and olfactory systems interact in multi-sensory integration of
chemical and thermal cues.
Aim 3) Probe the functions of the interneurons that process thermosensory input
In aim 3, we will determine the contribution of each projection neuron to thermotactic navigation through cell-
specific inhibition and activation of individual PNs combined with high-resolution behavioral analysis.
Taken together, these studies combine molecular genetics, physiology, and high resolution behavioral
analyses to perform a comprehensive analysis of how this relatively small neural circuit processes multiple,
distinct sensory inputs to control robust and flexible behaviors.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Garrity其他文献
Paul Garrity的其他文献
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{{ truncateString('Paul Garrity', 18)}}的其他基金
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- 批准号:
10608005 - 财政年份:2022
- 资助金额:
$ 53.23万 - 项目类别:
Predoctoral Training in Cross-disciplinary Molecular and Cellular Biology
跨学科分子和细胞生物学博士前培训
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10089175 - 财政年份:2021
- 资助金额:
$ 53.23万 - 项目类别:
Predoctoral Training in Cross-disciplinary Molecular and Cellular Biology
跨学科分子和细胞生物学博士前培训
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10620263 - 财政年份:2021
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$ 53.23万 - 项目类别:
The molecular and cellular basis of short-range host cue sensing in mosquito vectors
蚊子媒介短程宿主线索感知的分子和细胞基础
- 批准号:
10683995 - 财政年份:2020
- 资助金额:
$ 53.23万 - 项目类别:
The molecular and cellular basis of short-range host cue sensing in mosquito vectors
蚊子媒介短程宿主线索感知的分子和细胞基础
- 批准号:
10468918 - 财政年份:2020
- 资助金额:
$ 53.23万 - 项目类别:
The molecular and cellular basis of short-range host cue sensing in mosquito vectors
蚊子媒介短程宿主线索感知的分子和细胞基础
- 批准号:
10267776 - 财政年份:2020
- 资助金额:
$ 53.23万 - 项目类别:
Molecular and cellular determinants of Drosophila larva thermotaxis
果蝇幼虫趋热性的分子和细胞决定因素
- 批准号:
9894808 - 财政年份:2019
- 资助金额:
$ 53.23万 - 项目类别:
Molecular and cellular determinants of Drosophila larva thermotaxis
果蝇幼虫趋热性的分子和细胞决定因素
- 批准号:
10093090 - 财政年份:2019
- 资助金额:
$ 53.23万 - 项目类别:
Unraveling the polymodal behavior of sensory transduction receptors
揭示感觉转导受体的多模式行为
- 批准号:
9225161 - 财政年份:2016
- 资助金额:
$ 53.23万 - 项目类别:
Unraveling the polymodal behavior of sensory transduction receptors
揭示感觉转导受体的多模式行为
- 批准号:
9126864 - 财政年份:2016
- 资助金额:
$ 53.23万 - 项目类别:
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