Mentoring in patient-oriented research on HIV and global health

项目摘要 这个K24职业生涯中期研究者奖的目的是支持巴塞特博士的指导活动， 以患者为导向的研究，以改善全球艾滋病毒护理和相关条件的参与。巴塞特博士是一位 执业传染病医生，拥有超过14年的经验，领导南方的临床研究 非洲有关艾滋病和结核病的筛查和治疗，为此她获得了艾滋病医学协会 2015年研究奖。她曾担任15名年轻调查人员的导师，其中4人目前正在 获得K奖。巴塞特博士坚定地致力于继续并进一步扩大她的指导， 包括来自传染病科以外和撒哈拉以南非洲受训人员。她有 她组建了一个多学科的顾问团队，可以支持她和她的学员的职业发展。博士 巴西特是哈佛艾滋病研究发展核心中心及其指导中心的主任 程序，并指导一个模拟K赠款审查会议每年三次，以及赠款写作研讨会， 哈佛社区。她在2013年获得了哈佛医学院青年导师奖，以表彰 她的指导活动。她提出了一套相互关联的培训、指导和研究目标， 将她的研究范围扩大到新的领域（例如艾滋病毒预防，以社区为基础的艾滋病毒治疗， 非传染性疾病）。这个K24将为巴塞特博士提供：1）保护时间， 指导致力于以患者为导向的艾滋病毒研究的早期职业研究人员，包括那些位于亚 撒哈拉非洲，2）混合方法的职业中期专业发展平台，实施 科学方法，扩大导师和国际伙伴关系，以及3）新的机会， 数据收集，以告知她的学员'和她自己的未来的研究计划。巴塞特医生会利用她 南非德班Umlazi镇艾滋病毒高感染率社区的合作和伙伴关系 这是一个沉重的负担，也是世界上年轻妇女中艾滋病毒发病率最高的国家之一。的总体目标 拟议的研究是发展创新的，以社区为基础的研究，解决基本问题 关于如何提高艾滋病毒预防和长期抗逆转录病毒治疗提供的吸收，以及如何整合其他 关键的健康需求，如糖尿病管理和避孕纳入艾滋病毒方案。建议的高- 影响研究在南非的一个高风险乡镇有直接和立即的应用，并将支持 受保护的时间和资源所需的巴塞特博士指导年轻的研究人员从美国和亚 撒哈拉非洲以病人为导向的研究。

PROJECT SUMMARY The purpose of this K24 mid-career investigator award is to support Dr. Bassett’s mentoring activities and patient-oriented research to improve engagement in HIV care and related conditions globally. Dr. Bassett is a practicing Infectious Disease physician with over 14 years of experience leading clinical research in South Africa related to HIV and TB screening and treatment, for which she received the HIV Medicine Association Research Award in 2015. She has served as a mentor to 15 young investigators, four of whom are currently supported by K awards. Dr. Bassett is deeply committed to continuing and further expanding her mentorship to include trainees from outside of Infectious Disease and those based in sub-Saharan Africa. She has assembled a multi-disciplinary team of advisors who can support her and her trainees’ career development. Dr. Bassett is the Director of the Harvard Center for AIDS Research Developmental Core and its Mentoring Programs, and directs a mock K grant review session three times yearly as well as a grant-writing workshop for the Harvard community. She won the Harvard Medical School Young Mentor Award in 2013 in recognition of her mentoring activities. She proposes an inter-related set of training, mentoring and research objectives that expand the scope of her research into new areas (e.g. HIV prevention, community-based treatment for HIV- associated non-communicable diseases). This K24 would provide Dr. Bassett with: 1) protected time for mentoring early career investigators dedicated to patient-oriented HIV research, including those based in sub- Saharan Africa, 2) a platform for mid-career professional development in mixed methods, implementation science approaches, and expanded mentorship and international partnerships, and 3) an opportunity for new data collection to inform her mentees’ and her own future research programs. Dr. Bassett will leverage her collaborations and partnerships in Umlazi Township, Durban, South Africa, a community with a high HIV burden and one of the highest HIV incidences among young women in the world. The overall goal of the proposed research is to develop innovative, community-based research that addresses fundamental questions about how to improve uptake of HIV prevention and long-term ART provision, as well as how to integrate other critical health needs such as diabetes management and contraception into HIV programs. The proposed high- impact research has direct and immediate application in a high-risk South African township and will support the protected time and resources required for Dr. Bassett to mentor young investigators from both the US and sub- Saharan Africa in patient-oriented research.