The mathematics of stochastic transport and signalling in cells

细胞中随机运输和信号传导的数学

• 批准号: DP210100255
• 负责人: Prof Adelle Coster
• 金额: $ 30.61万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-12-30 至 2024-12-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100255
• 关键词: mathematics; stochastic; transport; signalling; cells

The project aims to develop new stochastic mathematical models of the dynamics of protein transport and cell signalling. The mathematics will link macro scale biological observations to micro scale molecular movements to characterise the relative role that different components and processes play. Expected outcomes are robust mathematical analyses of the transient dynamics of closed, finite capacity queueing networks and biological insight into the major control mechanisms in cellular insulin signalling. The project should provide significant benefits via the delivery of new mathematical tools and analysis for stochastic networks, impacting our understanding of metabolic transport, and providing interdisciplinary research training.

该项目旨在开发蛋白质运输和细胞信号传导动力学的新随机数学模型。数学将宏观尺度的生物观察与微观尺度的分子运动联系起来，以表征不同成分和过程所起的相对作用。预期的结果是对封闭、有限容量排队网络的瞬态动力学进行强大的数学分析，并对细胞胰岛素信号传导的主要控制机制进行生物学洞察。该项目将通过提供新的数学工具和随机网络分析，影响我们对代谢运输的理解，并提供跨学科的研究培训，从而带来显著的好处。