Project 3

项目3

基本信息

  • 批准号:
    10349753
  • 负责人:
  • 金额:
    $ 22.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-20 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

Project 3 Abstract Exposures to environmental hazardous substances, including those in the event of natural and anthropogenic disasters, are known to negatively impact pregnancy, leading to adverse outcomes such as preterm birth (PTB). However, establishing a clear link between exposure and pregnancy risk is challenging, due to lack of a mechanistic knowledge by which toxicants activate pathways causing PTB in maternal-fetal tissues. Unfortunately, current in vitro and in vivo toxicity testing models are either not sufficient in assessing the hazards of tested substances on pregnancy outcomes, do not represent the human in utero structure and functions accurately, or are too costly and low throughput. In addition, assessment of the hazards imposed by exposures to complex environmental samples that may contain multiple hazardous chemicals, often observed after disasters, is even more challenging. Here, we propose to develop a feto-maternal (F-M) interface tissue chip- based testing strategy for assessing the human health hazard of environmental substances on PTB. Our central hypothesis is that a tissue chip model that mimics the physiology of the complex multi-cellular F-M interface will enable evaluation of the mechanistic pathophysiologic pathways affected by exposure to complex environmental hazardous substances that may increase the risk of PTB. These tissue chip models mimic the fetal and maternal uterine tissues structurally and functionally, and will be used to evaluate mechanistic pathophysiologic pathways in the F-M interface imposed by complex mixed environmental hazardous substances. This will be accomplished through the following three aims. In Aim 1, we will develop a mechanistic model of PTB in response to environmental toxicants using a fetal membrane tissue chip model. In Aim 2, we will develop a mechanistic model of PTB in response to environmental toxicants using a placenta tissue chip model. In Aim 3, which will focus on the application of our novel models for Disaster Research Response (DR2), we will demonstrate rapid assessment of the potential human health hazards of environmental exposures on disrupting F-M homeostasis that can lead to PTB by using a higher-throughput F-M tissue chip model. The success of this proposed research will provide critical and timely information for hazard assessment on toxicants’ impact on PTB using tissue chip models, especially related to toxicants from existing Superfund sites and from emergency disaster-related contaminants. Thematically, this project is well integrated into the Texas A&M University Superfund Research Center that is focusing on addressing the human health risks of exposure to hazardous substances during and after emergencies, especially the effects on particularly vulnerable populations (pregnant women and children).
项目3摘要

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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Arum Han其他文献

Arum Han的其他文献

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{{ truncateString('Arum Han', 18)}}的其他基金

3-D biofabricated feto-maternal interface tissue model to determine drug efficacy during pregnancy to reduce the risk of preterm birth
3D 生物制造胎儿-母体界面组织模型,用于确定妊娠期间的药物疗效,以降低早产风险
  • 批准号:
    10438407
  • 财政年份:
    2022
  • 资助金额:
    $ 22.26万
  • 项目类别:
3-D biofabricated feto-maternal interface tissue model to determine drug efficacy during pregnancy to reduce the risk of preterm birth
3D 生物制造胎儿-母体界面组织模型,用于确定妊娠期间的药物疗效,以降低早产风险
  • 批准号:
    10670735
  • 财政年份:
    2022
  • 资助金额:
    $ 22.26万
  • 项目类别:
Project 3
项目3
  • 批准号:
    10707445
  • 财政年份:
    2022
  • 资助金额:
    $ 22.26万
  • 项目类别:
Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip
通过使用芯片上的母胎界面开发基于细胞外囊泡的早产疗法
  • 批准号:
    10434794
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Administrative Supplement to Intercellular interactions define cell migrations and transitions that maintain fetal membrane homeostasis
细胞间相互作用的行政补充定义了维持胎膜稳态的细胞迁移和转变
  • 批准号:
    10177264
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Intercellular interactions define cell migrations and transitions that maintain fetal membrane homeostasis
细胞间相互作用定义了维持胎膜稳态的细胞迁移和转变
  • 批准号:
    10356919
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Accelerating discovery of neutralizing paratopes with Functional Antibody Screening Technology
利用功能性抗体筛选技术加速中和互补位的发现
  • 批准号:
    10088379
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip
通过使用芯片上的母胎界面开发基于细胞外囊泡的早产疗法
  • 批准号:
    10037855
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip
通过使用芯片上的母胎界面开发基于细胞外囊泡的早产疗法
  • 批准号:
    10492233
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:
Intercellular interactions define cell migrations and transitions that maintain fetal membrane homeostasis
细胞间相互作用定义了维持胎膜稳态的细胞迁移和转变
  • 批准号:
    10571858
  • 财政年份:
    2020
  • 资助金额:
    $ 22.26万
  • 项目类别:

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