Project 5
Project 5
批准号:
10349755
负责人:
Timothy Phillips
金额:
$20.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-20 至 2027-06-30
关键词:
AddressAffinityAirAmendmentAnimalsAreaBindingBiologicalBiological AssayBiological AvailabilityBiological ModelsCaenorhabditis elegansChemical ExposureChemicalsCnidariaCollaborationsCommunitiesCompetenceComputing MethodologiesData AnalysesDermalDevelopmentDimensionsDisastersDrug Metabolic DetoxicationEmergency SituationEmergency responseEngineeringEnsureEnvironmentEnvironmental ScienceEventExposure toFeedbackFoodFood ContaminationFood SupplyFormulationFrontline workerFundingGardenalGoalsHazardous ChemicalsHazardous SubstancesHumanIn VitroIndividualIngestionInhalationInhalation ExposureKineticsLegal patentLicensingLifeMasksMethodologyMethodsMinorModelingNatural DisastersNeighborhoodsNematodaOrganismOutcomePathway interactionsPersonsPlantsPlayProcessProductionPropertyReactionResearchResearch PersonnelRiskRoleSafetySamplingScienceSiteSkinSoilSourceSuperfundSurfaceTechnologyTechnology TransferTestingThermodynamicsToxic effectTrainingTranslational ResearchTranslationsVulnerable PopulationsWaterWater SupplyWorkabsorptionbasecommunity engagementcontaminated waterdata managementdermal exposuredesigndosimetrydrinking waterefficacy validationenvironmental chemicalexperienceexperimental studyface maskfirst responderin silicoin vivoin vivo Modelinsightman-made disastersmembermolecular dynamicsnovelresponsesuccesssuperfund sitetooluptakevulnerable community
中文摘要
项目5
环境中危险物质的影响可能会因其动员和扩散而加剧,
在自然灾害和紧急情况发生后,受污染的沉积物、土壤、水和空气的重新分布。立即
令人关切的是安全饮水和食品供应的安全。其他威胁包括土壤污染(草坪、社区
花园、公园和娱乐场所),沿着人类皮肤接触和吸入接触的风险增加
在撞击地点附近与这些紧急情况相关的一个主要挑战是保护弱势群体,
社区和社区,灾难的第一反应者,前线人员,以及参与
场地的管理和清理。因此,能够迅速减少有害物质的影响,
灾害事件是一项关键需求。在本提案的目标1中,将由以下物质合成多组分吸附剂:
不同的材料和化合物,通常被认为是安全的(GRAS),这些吸附剂将紧密
结合环境化学品并设计具有高容量和亲和力的混合物。反应动力学,
热力学和基本机制涉及的表面之间的相互作用,选择
吸附剂材料和危险环境化学品和混合物将确定使用目前
可用的体外方法。计算方法将用于验证和提供基本见解,
以及预测吸附剂性能和筛选最佳GRAS修正物,从而提供反馈,
与所有实验的结合。具有低耐受性的成熟的动物和植物有机体
水、土壤和沉积物中的环境化学物质将包括刺胞动物模型系统(水螅),
浮萍(浮萍)测定法和秀丽隐杆线虫(Caillhabditis elegans)线虫测定法。这些活体(In vivo)
模型系统将用于预测污染样品的毒性,并验证我们选择的有效性
吸附剂和我们的体外和计算机结果。在目标2中,将开发多组分吸附剂,
从受污染的食物、饮用水和土壤中清除有害物质。新型屏障制剂将
开发用于皮肤保护和防护面罩中的过滤器插入物,以减少皮肤和吸入
暴露于化学品。在目标3中,我们的体内模型将用于评估现实环境样品
从灾难现场和特征鲜明的超级基金现场。在这些研究中,
将决定是否列入有害物质,以使其解毒。现有合作
核心的、成熟的技术转让专业知识和跨学科的互动
在项目5中,将为整个中心增加一个重要的能力和规模。项目到外地的途径,
在我们的过程中,开发广泛作用的吸附剂和危险化学品配方,
研究已经牢固确立。我们已经确定了相关的利益攸关方和弱势群体,
将受益于这些产品。预计本研究中开发的吸附剂和屏障技术将
减少灾害和紧急情况下人和动物接触化学品的机会。
英文摘要
Project 5 ABSTRACT
The effects from hazardous substances in the environment can be compounded by their mobilization and
redistribution in polluted sediment, soil, water and air following natural disasters and emergencies. Of immediate
concern is the safety of safe water and food supplies. Other threats include soil contamination (lawns, community
gardens, parks and recreational areas), along with increased risk of human dermal and inhalation exposures
near the site of the impact. A major challenge associated with these emergencies is protecting vulnerable
communities and neighborhoods, first responders to the disaster, frontline personnel, and those involved in the
management and cleanup of the site. Thus, the ability to rapidly minimize hazardous substance effects during
disaster events is a critical need. In Aim 1 of this proposal, multicomponent sorbents will be synthesized from
diverse materials and compounds that are generally recognized as safe (GRAS), and these sorbents will tightly
bind environmental chemicals and design mixtures with high capacity and affinity. The reaction kinetics,
thermodynamics and fundamental mechanism(s) involved in interactions between the surfaces of selected
sorbent materials and hazardous environmental chemicals and mixtures will be determined using currently
available in vitro methods. Computational methods will be used to validate and provide fundamental insights, as
well as to predict sorbent properties and screen for optimum GRAS amendments, thus providing feedback and
integration with all experiments. Well-established animal and plant organisms that possess a low tolerance for
environmental chemicals in water, soil, and sediment will include the Cnidarian model system (Hydra vulgaris),
the Lemna minor (duckweed) assay, and the Caenorhabditis elegans nematode assay. These living (in vivo)
model systems will be used to predict the toxicity of polluted samples and to validate the efficacy of our selected
sorbents and our in vitro and in silico results. In Aim 2, multicomponent sorbents will be developed that will
remove hazardous substances from contaminated food, drinking water and soil. Novel barrier formulations will
be developed for skin protection and for filter inserts in protective masks to reduce dermal and inhalation
exposures to chemicals. In Aim 3, our in vivo models will be used to evaluate real-life environmental samples
from disaster sites and well-characterized superfund sites. In these studies, optimal sorbents and levels of
inclusion that will result in detoxification of hazardous substances will be determined. Existing collaborations with
Community Engagement Core, well-established technology transfer expertise, and interdisciplinary interactions
in Project 5 will add an important capability and dimension to the overall Center. The project-to-field pathway for
the development of broad-acting sorbents and formulations for hazardous chemicals during the course of our
study has been firmly established. We have identified relevant stakeholders and vulnerable communities that
will benefit from these products. It is expected that sorbent and barrier technology developed in this research will
result in reduced chemical exposures in people and animals during disasters and emergencies.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Project 5
-
批准号:10707458
-
项目类别:
-
资助金额:$20.19万
-
财政年份:2022
-
负责人:Timothy Phillips
-
依托单位:
Prevention of hepatocellular carcinoma in vulnerable communities in Texas
-
批准号:8147016
-
项目类别:
-
资助金额:$32.33万
-
财政年份:2010
-
负责人:Timothy Phillips
-
依托单位:
Prevention of hepatocellular carcinoma in vulnerable communities in Texas
-
批准号:8288643
-
项目类别:
-
资助金额:$32.97万
-
财政年份:2010
-
负责人:Timothy Phillips
-
依托单位:
Prevention of hepatocellular carcinoma in vulnerable communities in Texas
-
批准号:8495791
-
项目类别:
-
资助金额:$30.83万
-
财政年份:2010
-
负责人:Timothy Phillips
-
依托单位:
Prevention of hepatocellular carcinoma in vulnerable communities in Texas
-
批准号:8035155
-
项目类别:
-
资助金额:$38.0万
-
财政年份:2010
-
负责人:Timothy Phillips
-
依托单位:
Core--Training
-
批准号:6901629
-
项目类别:
-
资助金额:$9.53万
-
财政年份:2005
-
负责人:Timothy Phillips
-
依托单位:
Chemical Intervention Strategies
-
批准号:6901620
-
项目类别:
-
资助金额:$12.99万
-
财政年份:2005
-
负责人:Timothy Phillips
-
依托单位:
Chemical intervention strategies
-
批准号:6578790
-
项目类别:
-
资助金额:$7.35万
-
财政年份:2002
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6578785
-
项目类别:
-
资助金额:$7.35万
-
财政年份:2002
-
负责人:Timothy Phillips
-
依托单位:
Chemical intervention strategies
-
批准号:6442530
-
项目类别:
-
资助金额:$7.35万
-
财政年份:2001
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6442525
-
项目类别:
-
资助金额:$7.35万
-
财政年份:2001
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6301379
-
项目类别:
-
资助金额:$7.35万
-
财政年份:2000
-
负责人:Timothy Phillips
-
依托单位:
DEVELOPMENTAL TOXICITY
-
批准号:6106228
-
项目类别:
-
资助金额:$11.82万
-
财政年份:1999
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6106231
-
项目类别:
-
资助金额:$11.82万
-
财政年份:1999
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6271116
-
项目类别:
-
资助金额:$11.88万
-
财政年份:1998
-
负责人:Timothy Phillips
-
依托单位:
DEVELOPMENTAL TOXICITY
-
批准号:6271113
-
项目类别:
-
资助金额:$11.88万
-
财政年份:1998
-
负责人:Timothy Phillips
-
依托单位:
CORE--TRAINING CORE
-
批准号:6239533
-
项目类别:
-
资助金额:$11.54万
-
财政年份:1997
-
负责人:Timothy Phillips
-
依托单位:
DEVELOPMENTAL TOXICITY
-
批准号:6239530
-
项目类别:
-
资助金额:$11.54万
-
财政年份:1997
-
负责人:Timothy Phillips
-
依托单位:
Chemical intervention strategies
-
批准号:6345334
-
项目类别:
-
资助金额:$7.35万
-
财政年份:1988
-
负责人:Timothy Phillips
-
依托单位:
Chemical Intervention Strategies
-
批准号:7404532
-
项目类别:
-
资助金额:$14.73万
-
财政年份:--
-
负责人:Timothy Phillips
-
依托单位:
海外基金