Chemical Intervention Strategies

化学干预策略

• 批准号: 6901620
• 负责人: Timothy Phillips
• 金额: $ 12.99万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901620
• 关键词: aromatic hydrocarbon receptor; arsenic; chelating agents; chemical binding; clay; dietary supplements; dioxins; embryo /fetus therapy; embryo /fetus toxicology; environmental contamination; folate; gastrointestinal toxin absorption; genetically modified animals; laboratory mouse; nutrition related tag; soil pollution; water pollution; water treatment

Concerns about the quality and safety of our environment have evoked a growing awareness of the hazards associated with diverse organic and metal pollutants in groundwater from Superfund sites and (more recently) drinking water and foods destined for human consumption. Many of these prioritized environmental contaminants (ECs) can have severe and long lasting effects on health. The scope of the problem is broader still, since ECs routinely occur as complex mixtures, the toxicities and interactions of which are ill-defined. Clearly, appropriate and practical intervention strategies for the remediation of contaminated food and water and the prevention of EC-induced disease in humans are high priorities. In this project, our specific aims are fourfold, and based on the central hypothesis that effective sorbent-based interventions can be developed to significantly diminish exposure (and risk) from EC-contaminated water and food. It is further postulated that EC-selective composite media and optimal binding agents can be developed to purify groundwater, as well as diminish the bioavailability of ECs from the gastrointestinal tract of humans and animals when included in the diet, Our experiments will focus on identifying and investigating high affinity sorbents and multifunctional binding agents for the remediation of ECs (i.e. PAHs, chlorinated organics, and toxic metals) via water purification or by enterosorbent therapy through the diet. Binding agents will encompass a variety of clay and zeolitic minerals, biopolymers, and antibody-based materials, as well as chemically modified analogs and optimal composite mixtures. Also, "iron-impregnated" and "amended clay-encapsulated" chitosan gel beads and analogs will be developed and tested for their ability to sequester arsenic and TCDD from aqueous solutions and for their efficacy in preventing the toxicity of arsenic and TCDD in utero. In inter-project collaboration, folate transport deficient mice and Ah/R knockout mice will be used as genetically sensitive models for arsenic and TCDD, respectively. !n these studies, we will determine if prioritized enterosorbents, provided as dietary supplements, can rescue mice from teratogenesis and developmental toxicity when challenged by sodium arsenate and TCDD. The long-term goal of this project is to provide innovative chemical and biological interventions that will enhance environmental risk management by reducing exposure of humans and animals to high priority ECs from water and food.

人们对我们环境的质量和安全性的担忧引起了人们对与超级基金站点的地下水中各种有机和金属污染物相关的危害的认识，以及（最近）饮用水和食物供人类消费。这些优先的环境污染物（EC）中的许多人可能对健康产生严重且持久的影响。该问题的范围更广泛，因为EC通常以复杂的混合物，毒性和相互作用的定义不明显。显然，为修复受污染的食物和水的修复以及预防人类EC诱发的疾病的适当干预策略是重点。在这个项目中，我们的具体目标是四倍，基于中心假设，即可以开发出有效的基于吸附剂的干预措施，以大大减少EC污染的水和食物的暴露（和风险）。进一步假定，可以开发出EC选择性的复合培养基和最佳结合剂来净化地下水，并降低EC在饮食中包括的人类和动物胃肠道中的EC的生物利用性，当我们的实验中，我们的实验将专注于识别和研究高亲和力和效能的ecs-ecs-ecs-ecs-ecs-ecsermist（I. I.金属）通过净水或通过饮食进行肠吸附治疗。结合剂将涵盖各种粘土和沸石矿物质，生物聚合物和抗体基材料，以及化学改性的类似物和最佳的复合混合物。此外，将开发和测试“铁浸信”和“修订的粘土封装”的壳聚糖凝胶珠和类似物，并测试它们从水溶液中隔离砷和TCDD的能力，以及它们在YETERO中防止砷和TCDD的毒性的功效。在项目间协作中，叶酸传输缺陷小鼠和AH/R敲除小鼠将分别用作砷和TCDD的遗传敏感模型。 ！ 受砷酸钠和TCDD的挑战。该项目的长期目标是提供创新的化学和生物学干预措施，从而通过减少人类和动物的暴露于水和食物中的高优先级EC来增强环境风险管理。