Targeting the Patient Microbiome for the Prevention of Surgical Site Infection in Spine Surgery
针对患者微生物群预防脊柱手术中的手术部位感染
基本信息
- 批准号:10348358
- 负责人:
- 金额:$ 16.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-15 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAgeAnatomyAnesthesiologyAnteriorAntibiotic ProphylaxisAntibiotic TherapyAntimicrobial ResistanceAwardBackBacteriaBacterial GenomeCaringCategoriesCefazolinCervicalCessation of lifeChestClinicalComplexData SetDegenerative DisorderDevelopmentDevelopment PlansDiseaseEligibility DeterminationEnvironmentEscherichiaFoundationsFutureGeneticGenetic DeterminismGenomicsGoalsHospitalsIndividualInfectionInfection preventionKlebsiellaLeadMeasuresMedical centerMentorsMethicillin ResistanceMethodsMicrobiologyMolecularMolecular EpidemiologyMusculoskeletalNoseOperative Surgical ProceduresOutcomePainPathogenesisPatientsPerioperativePerioperative CarePowder dose formPreventionPrevention MeasuresPrevention strategyProceduresProphylactic treatmentProteusPublic HealthRepeat SurgeryResearchResearch ActivityResistanceResistance to infectionRiskRisk FactorsRoleSafetySamplingSkinSourceSpecimenSpinalSpinal FusionSpine surgeryStaphylococcus aureusSurgical Wound InfectionSurgical incisionsTechniquesTrainingTranslational ResearchTraumaVancomycinVertebral columnWomanWorkWound Infectionbacterial geneticsbiomedical referral centercareercareer developmentclinical riskclinically actionablecommensal bacteriacostdisabilityfecal microbiomefunctional outcomesgenome wide association studyhigh riskhospital readmissionhost colonizationimprovedinfection rateinstrumentinstrumentationmenmethicillin resistant Staphylococcus aureusmicrobiomemicrobiome researchmodifiable riskmolecular markernasal microbiomeneoplasticnovelpathogenpatient populationpersonalized approachpreservationprospectiveresearch and developmentscreeningsexskin microbiomesurgical risktooltraitwound
项目摘要
PROJECT SUMMARY/ABSTRACT
Surgical site infection (SSI) is a major public health problem with devastating perioperative outcomes,
affecting as many as 1 in 20 patients undergoing instrumented spine surgery. Procedures such as spinal fusion
comprise the largest overall category of US spending on surgical care and are frequently performed for
patients with pain or disability arising from a wide range of musculoskeletal conditions, such as congenital or
degenerative disease, trauma, and neoplastic disorders. However, SSI rates in instrumented spine surgery are
among the highest of any procedure involving a clean skin incision and they have not substantially decreased
in decades. The development of more effective strategies for SSI prevention in spine surgery is significantly
limited by a lack of fundamental understanding about the origins of causative bacteria, the basic pathogenesis
of spinal wound infection, the microbiome of the back, and the role of antimicrobial resistance to surgical
prophylaxis. We recently demonstrated that the microbiologic causes of spine SSI may vary by operative level
and patient sex, and that most infections are resistant to the surgical antibiotic prophylaxis administered.
The objectives of this K23 proposal are to build upon this foundation through training in translational
microbiome sciences and by prospectively characterizing the role of the patient microbiome in spine SSI. The
central hypothesis is that most spine SSIs arise from strains colonizing the patient prior to surgery (rather
than acquired in the hospital environment) and that clinically actionable features of the preoperative patient
microbiome strongly influence individual, modifiable risk. The long-term objective of this work is to use novel
bacterial genomic techniques and large clinical datasets to identify the fundamental mechanisms by which
spinal wound infection occurs, enabling the development of more effective prevention strategies. The specific
aims of this proposal are to: 1) define preoperative bacterial genetic features of Staphylococcus aureus
associated with spine SSI, allowing development of improved screening and decolonization measures, 2)
identify sources of endogenous gram-negative spine SSI and associated resistance to surgical antibiotic
prophylaxis, enabling prevention strategies for this important class of infection that may disproportionately
affect specific groups (e.g., women undergoing lumbosacral procedures), and 3) determine clinical risk factors
for resistance to surgical antibiotic prophylaxis in spine surgery to inform tailored approaches to selection of
antibiotic prophylaxis in spine surgery for diverse patient populations.
These research activities are closely aligned with my career development plans. Through the team of
expert mentors assembled from anesthesiology, surgery, and molecular microbiology, I will receive training in
cutting-edge translational microbiome research and career development toward independence. This award will
prepare me for my first R01 submission on tailored SSI prevention tools/strategies for clinical use in spine
surgery and for an independent translational research career in perioperative infection prevention.
项目总结/摘要
手术部位感染(SSI)是一个主要的公共卫生问题,具有毁灭性的围手术期结局,
影响多达1/20的接受脊柱内固定手术的患者。脊柱融合术等手术
包括美国外科护理支出的最大类别,并且经常用于
患有各种肌肉骨骼疾病引起的疼痛或残疾的患者,例如先天性或
退行性疾病、创伤和肿瘤性疾病。然而,脊柱内固定手术的SSI发生率
在涉及干净皮肤切口的任何手术中,
几十年来。在脊柱手术中开发更有效的SSI预防策略具有重要意义
由于缺乏对致病细菌起源的基本了解,
脊柱伤口感染,背部微生物组,以及抗菌素耐药性对手术的作用
预防。我们最近证实,脊柱SSI的微生物原因可能因手术节段而异
和患者性别,并且大多数感染对给予的外科抗生素预防具有抗性。
本K23提案的目标是通过翻译培训在此基础上建立
微生物组科学,并通过前瞻性地表征患者微生物组在脊柱SSI中的作用。的
中心假设是大多数脊柱SSI是由手术前患者体内的应变引起的(而不是
而不是在医院环境中获得)以及术前患者的临床上可操作的特征
微生物组强烈影响个体,可改变的风险。这项工作的长期目标是使用新的
细菌基因组技术和大型临床数据集,以确定基本机制,
脊柱伤口感染的发生,使更有效的预防策略的发展。具体
本建议的目的是:1)确定术前金黄色葡萄球菌的细菌遗传特征
与脊柱SSI相关,允许开发改进的筛查和去殖民化措施,2)
确定内源性革兰氏阴性脊柱SSI来源和相关的外科抗生素耐药性
预防,使预防战略,这一重要类别的感染,
影响特定群体(例如,接受腰骶手术的女性),以及3)确定临床风险因素
针对脊柱手术中对外科抗生素预防的耐药性,
不同患者人群脊柱手术中的抗生素预防。
这些研究活动与我的职业发展计划密切相关。通过团队,
来自麻醉学、外科学和分子微生物学的专家导师,我将接受以下培训:
尖端的翻译微生物组研究和职业发展走向独立。这个奖项将
准备我的第一份R 01提交文件,内容是脊柱临床使用的定制SSI预防工具/策略
外科手术和围手术期感染预防的独立转化研究事业。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dustin R Long其他文献
Dustin R Long的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dustin R Long', 18)}}的其他基金
Targeting the Patient Microbiome for the Prevention of Surgical Site Infection in Spine Surgery
针对患者微生物群预防脊柱手术中的手术部位感染
- 批准号:
10592249 - 财政年份:2022
- 资助金额:
$ 16.63万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 16.63万 - 项目类别:
Research Grant