Cannabis use among older adults: Potential risks and benefits to an aging population

老年人吸食大麻：人口老龄化的潜在风险和益处

• 批准号: 10348730
• 负责人: Angela Bryan
• 金额: $ 61.89万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10348730
• 关键词: Accounting; Acute; Adult; Age; Aging; American; Anxiety; Applications Grants; Area; Benefits and Risks; Blood; Cannabidiol; Cannabinoids; Cannabis; Colorado; Control Groups; Data; Decision Aid; Decision Making; Elderly; Epidemiology; Exercise; Goals; Harm Reduction; Human; Laboratories; Legal; Life; Medical; Medical Marijuana; Mental Depression; Motor; Neurocognition; Neurocognitive; Older Population; Outcome; Pain; Participant; Patient Self-Report; Patients; Pharmacology; Physiology; Play; Population; Prevalence; Process; Public Health; Publishing; Qualitative Methods; Quality of life; Regulation; Reporting; Research; Research Infrastructure; Risk; Role; Schedule; Sleep; Sleeplessness; Surveys; Symptoms; Tetrahydrocannabinol; Time; Work; age group; aged; aging population; behavioral pharmacology; cognitive function; comparison group; design; epidemiologic data; experience; impression; innovation; interest; marijuana legalization; marijuana use; marijuana user; motor control; negative affect; patient oriented; prospective; recruit; symptomatic improvement; virtual

Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the challenge is to assure that quality of life is being maintained along with quantity of life. Research is beginning to focus on understanding the changing physiology underlying normal human aging, as well as expand on behavioral and pharmacological strategies that may assist older adults to maximize their later years, and recent surveys suggest that some may believe that legalized cannabis products have a role to play. Simultaneously, the increasing legalization and acceptance of cannabis is occurring at a rapid pace. Older adults are the fastest growing group of cannabis users in the U.S., with prevalence up by 250% for in some age groups, who perceive virtually no risk of using cannabis monthly (85.3%) or even weekly (79%). National Surveys also showed that older adults were more likely to use cannabis for medicinal purposes than for recreational purposes, and common reasons for use include pain, anxiety, depression, and insomnia. There are obvious and critical questions that this situation poses. First, do older adults experience relief from their symptoms and does this depend on the constituent cannabinoids of the product they are using? Second, are there impacts on neurocognition and motor control that might be harmful, or even potentially beneficial, and do these, too, depend on the cannabinoid profile of the products being used? Third, how can we assist older adults in decision-making regarding cannabis? The overarching goal of this grant application is to leverage our innovative mobile pharmacology laboratory approach and existing aging research infrastructure to better understand the effects of legal market cannabis in adults aged 60 and over. To that end, the proposed research will utilize a prospective, patient-centered observational design to recruit and assess older adults who are interested in using cannabis for pain, trouble sleeping, or negative affect and a comparison group who are not interested in cannabis use. Users will choose and use one of three types of edible cannabis products (i.e., a CBD dominant product, a THC+CBD product, or a THC dominant product) for a total of three months. The proposed research has three aims. First, we will explore the effects of edible cannabis of varying composition among older adults who desire to use cannabis to treat their pain, trouble sleeping, or negative affect (depression/anxiety) as compared to a non-sing comparison group assessed by changes in the Patient Global Impression of Change scale. Second we will explore the effects of edible cannabis use of varying composition on neurocognition and motor control both acutely and over time among older adults. Finally, we will examine the process by which older adult cannabis users decide what type of cannabis product they prefer. Pursuit of these aims has tremendous

项目概要 美国老年人口急剧增加，从 4800 万翻倍至 8800 万 到 2050 年。随着越来越多的美国人寿命延长，面临的挑战是确保生活质量得到改善 与生命量一起维持。研究开始集中于理解正在发生的变化 人类正常衰老的生理学，以及行为和药理学策略的扩展 这可能有助于老年人最大限度地享受晚年生活，最近的调查表明，有些人可能认为 大麻产品合法化可以发挥作用。与此同时，日益合法化和 人们对大麻的接受正在迅速发生。老年人是大麻增长最快的群体 美国用户的某些年龄组的流行率高达 250%，他们认为几乎没有使用风险 每月一次（85.3%）甚至每周一次（79%）吸食大麻。全国调查还显示，老年人更 可能将大麻用于医疗目的而不是娱乐目的，以及使用大麻的常见原因 包括疼痛、焦虑、抑郁和失眠。这种情况存在明显且关键的问题 姿势。首先，老年人的症状是否得到缓解，这是否取决于其成分 他们使用的产品中含有大麻素吗？其次，对神经认知和运动控制有影响吗？ 这可能是有害的，甚至可能是有益的，而且这些也取决于大麻素的成分 正在使用的产品？第三，我们如何帮助老年人做出有关大麻的决策？ 本次拨款申请的总体目标是利用我们创新的移动药理学实验室 方法和现有的老龄化研究基础设施，以更好地了解合法市场大麻的影响 60 岁及以上的成年人。为此，拟议的研究将利用前瞻性的、以患者为中心的 观察性设计，招募和评估对使用大麻止痛感兴趣的老年人， 睡眠困难或负面影响以及对大麻使用不感兴趣的对照组。 用户将选择和使用三种类型的食用大麻产品之一（即 CBD 主导产品、 THC+CBD 产品，或 THC 主导产品）总共三个月。拟议的研究有三项 目标。首先，我们将探讨不同成分的食用大麻对渴望的老年人的影响 与大麻相比，使用大麻来治疗疼痛、睡眠困难或负面情绪（抑郁/焦虑） 非歌唱对照组通过患者总体印象变化量表的变化进行评估。第二 我们将探讨使用不同成分的食用大麻对神经认知和运动控制的影响 在老年人中，无论是急性还是随着时间的推移。最后，我们将研究老年人的过程 大麻使用者决定他们喜欢什么类型的大麻产品。追求这些目标具有巨大的意义